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Vladusic, E.A.; Bussmann, L.E.; Visconti, P.E.; Stoka, A.M.; Rodriguez, J.B.; Gros, E.G.; Charreau, E.H. "Effects of juvenile hormone on mammalian steroidogenesis" (1994) Journal of Steroid Biochemistry and Molecular Biology. 50(3-4):181-187
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Abstract:

The effects of juvenile hormone-III (JH-III) and the JH analogue 2-(4-phenoxyphenoxy)-ethoxytetrahydropiran on testicular steroidogenesis were studied. By using cultured MA-10 Leydig tumor cells as a model, these compounds were found to be potent inhibitors of LH/hCG steroidogenic action in a dose-dependent manner. Scatchard plot analysis of the binding data indicated that the JH analogue did not significantly alter the affinity nor the number of hCG binding sites, as well as GTP binding to plasma membranes. JH analogue inhibited the stimulatory action of both cholera toxin and forskolin on cAMP production and the concomitant steroidogenic response. JH analogue inhibited (Bu) 2 cAMP-stimulated progesterone synthesis, indicating that a process downstream to the adenylyl cyclase in the steroidogenic pathway is also affected. © 1994.

Registro:

Documento: Artículo
Título:Effects of juvenile hormone on mammalian steroidogenesis
Autor:Vladusic, E.A.; Bussmann, L.E.; Visconti, P.E.; Stoka, A.M.; Rodriguez, J.B.; Gros, E.G.; Charreau, E.H.
Filiación:Instituto de Biología y Medicina Experimental (IBYME)-CONICET Obligado 2490, Buenos Aires, 1428, Argentina
Departamento de Química Orgánica. Facultad de Ciencias Exactas y Naturales, U.B.A., Buenos Aires, Argentina
Palabras clave:adenylate cyclase; cyclic amp; juvenile hormone; juvenile hormone derivative; article; cell culture; leydig cell tumor; nonhuman; progesterone synthesis; steroidogenesis; testis; Animal; Cell Line; Cholera Toxin; Chorionic Gonadotropin; Cyclic AMP; Guanosine Triphosphate; Juvenile Hormones; Leydig Cells; Male; Mammals; Progesterone; Signal Transduction; Support, Non-U.S. Gov't; Mammalia
Año:1994
Volumen:50
Número:3-4
Página de inicio:181
Página de fin:187
DOI: http://dx.doi.org/10.1016/0960-0760(94)90027-2
Título revista:Journal of Steroid Biochemistry and Molecular Biology
Título revista abreviado:J. Steroid Biochem. Mol. Biol.
ISSN:09600760
CODEN:JSBBE
CAS:Cholera Toxin, 9012-63-9; Chorionic Gonadotropin; Cyclic AMP, 60-92-4; Guanosine Triphosphate, 86-01-1; Juvenile Hormones; Progesterone, 57-83-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v50_n3-4_p181_Vladusic

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Citas:

---------- APA ----------
Vladusic, E.A., Bussmann, L.E., Visconti, P.E., Stoka, A.M., Rodriguez, J.B., Gros, E.G. & Charreau, E.H. (1994) . Effects of juvenile hormone on mammalian steroidogenesis. Journal of Steroid Biochemistry and Molecular Biology, 50(3-4), 181-187.
http://dx.doi.org/10.1016/0960-0760(94)90027-2
---------- CHICAGO ----------
Vladusic, E.A., Bussmann, L.E., Visconti, P.E., Stoka, A.M., Rodriguez, J.B., Gros, E.G., et al. "Effects of juvenile hormone on mammalian steroidogenesis" . Journal of Steroid Biochemistry and Molecular Biology 50, no. 3-4 (1994) : 181-187.
http://dx.doi.org/10.1016/0960-0760(94)90027-2
---------- MLA ----------
Vladusic, E.A., Bussmann, L.E., Visconti, P.E., Stoka, A.M., Rodriguez, J.B., Gros, E.G., et al. "Effects of juvenile hormone on mammalian steroidogenesis" . Journal of Steroid Biochemistry and Molecular Biology, vol. 50, no. 3-4, 1994, pp. 181-187.
http://dx.doi.org/10.1016/0960-0760(94)90027-2
---------- VANCOUVER ----------
Vladusic, E.A., Bussmann, L.E., Visconti, P.E., Stoka, A.M., Rodriguez, J.B., Gros, E.G., et al. Effects of juvenile hormone on mammalian steroidogenesis. J. Steroid Biochem. Mol. Biol. 1994;50(3-4):181-187.
http://dx.doi.org/10.1016/0960-0760(94)90027-2