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Pecci, A.; Gomez-Sanchez, C.E.; de Bedners, M.E.O.; Lantos, C.P.; Cozza, E.N. "In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate" (1993) Journal of Steroid Biochemistry and Molecular Biology. 45(6):555-561
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Abstract:

Infusion of endothelin-1 (ET-1) into rats increased adrenal mitochondrial synthesis of aldosterone from deoxycorticosterone and the adrenal cytosolic content of aldosterone. The dose-response relationships for these last two effects of ET-1 were found to be biphasic with a maximum (corresponding to 80 to 200% increase) at 50 to 80 ng ET-1/kg/min, and were also dependent on the infusion rate. Plasma aldosterone levels were also increased in a similar ratio. Previous infusion of the converting enzyme inhibitor enalapril did not affect the ET-1-induced increase in steroidogenesis. Finally, pregnenolene production was also increased in incubations of mitochondria from treated rats. These results indicate that ET-1 augments aldosteronogenesis by increasing the early as well as the late pathway. These effects were independent of the formation of angiottensin II. Isolated glomerulosa cells responded to ET-1 increasing aldosterone production in a dose-related fashion. These results confirm a direct effect of ET-1 on the adrenal gland in vivo. © 1993.

Registro:

Documento: Artículo
Título:In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate
Autor:Pecci, A.; Gomez-Sanchez, C.E.; de Bedners, M.E.O.; Lantos, C.P.; Cozza, E.N.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires and PRHOM-CONICET, Cdad. Univ. Pab. II 4to piso, (1428) Buenos Aires, Argentina
Department of Internal Medicine, University of South Florida Health Science Center and James A Haley, Veterans' Hospital Tampa, FL 33612, United States
Palabras clave:aldosterone; angiotensin; angiotensin i; enalapril; endothelin 1; aldosterone blood level; aldosterone release; animal experiment; article; intravenous drug administration; male; nonhuman; priority journal; rat; steroidogenesis; Aldosterone; Angiotensin II; Animal; Cytosol; Dose-Response Relationship, Drug; Enalapril; Endothelins; Male; Mitochondria; Rats; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Zona Glomerulosa; Animalia
Año:1993
Volumen:45
Número:6
Página de inicio:555
Página de fin:561
DOI: http://dx.doi.org/10.1016/0960-0760(93)90172-S
Título revista:Journal of Steroid Biochemistry and Molecular Biology
Título revista abreviado:J. Steroid Biochem. Mol. Biol.
ISSN:09600760
CODEN:JSBBE
CAS:Aldosterone, 52-39-1; Angiotensin II, 11128-99-7; Enalapril, 75847-73-3; Endothelins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v45_n6_p555_Pecci

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Citas:

---------- APA ----------
Pecci, A., Gomez-Sanchez, C.E., de Bedners, M.E.O., Lantos, C.P. & Cozza, E.N. (1993) . In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate. Journal of Steroid Biochemistry and Molecular Biology, 45(6), 555-561.
http://dx.doi.org/10.1016/0960-0760(93)90172-S
---------- CHICAGO ----------
Pecci, A., Gomez-Sanchez, C.E., de Bedners, M.E.O., Lantos, C.P., Cozza, E.N. "In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate" . Journal of Steroid Biochemistry and Molecular Biology 45, no. 6 (1993) : 555-561.
http://dx.doi.org/10.1016/0960-0760(93)90172-S
---------- MLA ----------
Pecci, A., Gomez-Sanchez, C.E., de Bedners, M.E.O., Lantos, C.P., Cozza, E.N. "In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate" . Journal of Steroid Biochemistry and Molecular Biology, vol. 45, no. 6, 1993, pp. 555-561.
http://dx.doi.org/10.1016/0960-0760(93)90172-S
---------- VANCOUVER ----------
Pecci, A., Gomez-Sanchez, C.E., de Bedners, M.E.O., Lantos, C.P., Cozza, E.N. In vivo stimulation of aldosterone biosynthesis by endothelin: Loci of action and effects of doses and infusion rate. J. Steroid Biochem. Mol. Biol. 1993;45(6):555-561.
http://dx.doi.org/10.1016/0960-0760(93)90172-S