Artículo

Aragonés, A.; Gonzalez, C.B.; Spinedi, N.C.; Lantos, C.P. "Regulatory effects of 5β-reduced steroids" (1991) Journal of Steroid Biochemistry and Molecular Biology. 39(2):253-263
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Abstract:

The first section of this publication summarizes early work according to which 5β-pregnanedione is an important metabolite of progesterone in the early stages of the chick embryo's adrenal steroidogenesis, then decreasing gradually as corticosteroidogenesis increases. In the second section a model is described in which adrenal 3β-ol hydroxylase-isomerase of the 17-day-old chicken is suppressed pharmacologically, this suppression being correlated with that of the synthesis of aminoevulinic acid (ALA), the first and rate-limiting step of the heme pathway. 5β-Pregnanedione (10 -7 -10 -6 M) restored ALA synthesis in this inhibited model to normal values. The effect of 5β-pregnanedione was specific since other steroids tested: progesterone; 5α-pregnanedione; corticosterone or estradiol, did not stimulate ALA. Since heme formation by steroidogenic glands contributes to the synthesis of cytochrome P450 rather than hemoglobin, 5β-pregnanedione was also assayed as a stimulator of this enzyme system and was found to increase cytochrome P450 in adrenals and testes but not in the liver. In view of these results a hypothesis is advanced according to which 5β-reduced progestagens and androgens stimulate cytochrome P450 formation, i.e. the synthesis of progesterone and higher hydroxylated steroids, by steroidogenic glands in the event of an excessive precursor reduction. © 1991.

Registro:

Documento: Artículo
Título:Regulatory effects of 5β-reduced steroids
Autor:Aragonés, A.; Gonzalez, C.B.; Spinedi, N.C.; Lantos, C.P.
Filiación:PRHOM-CONICET and Laboratorio de Esteroides, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria- 1428, Buenos Aires, Argentina
Palabras clave:3(or 17)beta hydroxysteroid dehydrogenase; aminolevulinic acid; corticosterone; cytochrome p450; estradiol; pregnanedione; progesterone; adrenal gland; animal tissue; chicken; conference paper; embryo; newborn; nonhuman; priority journal; steroidogenesis; Aminolevulinic Acid; Animal; Chick Embryo; Chickens; Corticosterone; Cyanoketone; Cytochrome P-450 Enzyme System; Estradiol; Male; Oxidation-Reduction; Pregnanediones; Progesterone; Spironolactone; Steroids; Support, Non-U.S. Gov't
Año:1991
Volumen:39
Número:2
Página de inicio:253
Página de fin:263
DOI: http://dx.doi.org/10.1016/0960-0760(91)90071-C
Título revista:Journal of Steroid Biochemistry and Molecular Biology
Título revista abreviado:J. Steroid Biochem. Mol. Biol.
ISSN:09600760
CODEN:JSBBE
CAS:Aminolevulinic Acid, 106-60-5; Corticosterone, 50-22-6; Cyanoketone, 4248-66-2; Cytochrome P-450 Enzyme System, 9035-51-2; Estradiol, 50-28-2; Pregnanediones; Progesterone, 57-83-0; Spironolactone, 52-01-7; Steroids
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09600760_v39_n2_p253_Aragones

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Citas:

---------- APA ----------
Aragonés, A., Gonzalez, C.B., Spinedi, N.C. & Lantos, C.P. (1991) . Regulatory effects of 5β-reduced steroids. Journal of Steroid Biochemistry and Molecular Biology, 39(2), 253-263.
http://dx.doi.org/10.1016/0960-0760(91)90071-C
---------- CHICAGO ----------
Aragonés, A., Gonzalez, C.B., Spinedi, N.C., Lantos, C.P. "Regulatory effects of 5β-reduced steroids" . Journal of Steroid Biochemistry and Molecular Biology 39, no. 2 (1991) : 253-263.
http://dx.doi.org/10.1016/0960-0760(91)90071-C
---------- MLA ----------
Aragonés, A., Gonzalez, C.B., Spinedi, N.C., Lantos, C.P. "Regulatory effects of 5β-reduced steroids" . Journal of Steroid Biochemistry and Molecular Biology, vol. 39, no. 2, 1991, pp. 253-263.
http://dx.doi.org/10.1016/0960-0760(91)90071-C
---------- VANCOUVER ----------
Aragonés, A., Gonzalez, C.B., Spinedi, N.C., Lantos, C.P. Regulatory effects of 5β-reduced steroids. J. Steroid Biochem. Mol. Biol. 1991;39(2):253-263.
http://dx.doi.org/10.1016/0960-0760(91)90071-C