Viegas, L.R.; Hoijman, E.; Beato, M.; Pecci, A. "Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids" (2008) Journal of Steroid Biochemistry and Molecular Biology. 109(3-5):273-278
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Physiological cell turnover is under the control of a sharp and dynamic balance of different homeostatic mechanisms such as the equilibrium between cell proliferation and cell death. These mechanisms play an important role in maintaining normal tissue function and architecture. It is well known that apoptosis is the prevalent mode of physiological cell loss in most tissues. Steroid hormones like glucocorticoids have been identified as key signals controlling cell turnover by modulating programmed cell death in a tissue- and cell-specific manner. In this sense, several reports have demonstrated that glucocorticoids are able to induce apoptosis in cells of the hematopoietic system such as monocytes, macrophages, and T lymphocytes. In contrast, they protect against apoptotic signals evoked by cytokines, cAMP, tumor suppressors, in glandular cells such as the mammary gland epithelia, endometrium, hepatocytes, ovarian follicular cells, and fibroblasts. Although several studies have provided significant information on hormone-dependent apoptosis in an specific tissue, a clearly defined pathway that mediates cell death in response to glucocorticoids in different cell types is still misunderstood. The scope of this review is held to those mechanisms by which glucocorticoids control apoptosis, emphasizing tissue-specific expression of genes that are involved in the apoptotic pathway. © 2008 Elsevier Ltd. All rights reserved.


Documento: Artículo
Título:Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids
Autor:Viegas, L.R.; Hoijman, E.; Beato, M.; Pecci, A.
Filiación:Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Cdad. Universitaria, Pab. II, C1428EGA Buenos Aires, Argentina
Departamento de Fisiología, Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Cdad. Universitaria, Pab. II, C1428EGA Buenos Aires, Argentina
IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Cdad. Universitaria, Pab. II, C1428EGA Buenos Aires, Argentina
Centre de Regulació Genòmica (CRG), Universitat Pompeu Fabra, Passeig Maritim 37-49, 08003 Barcelona, Spain
Palabras clave:Apoptosis; Bcl-2 family proteins; Glucocorticoids; cyclic AMP; cytokine; dexamethasone; glucocorticoid; protein bcl 2; protein bcl x; tumor suppressor protein; apoptosis; breast epithelium; cell proliferation; endometrium; fibroblast; hematopoietic system; liver cell; macrophage; monocyte; nonhuman; ovary follicle cell; protein expression; review; T lymphocyte; Animals; Apoptosis; Biological Markers; Glucocorticoids; Humans; Organ Specificity; Proto-Oncogene Proteins c-bcl-2; Signal Transduction
Página de inicio:273
Página de fin:278
Título revista:Journal of Steroid Biochemistry and Molecular Biology
Título revista abreviado:J. Steroid Biochem. Mol. Biol.
CAS:cyclic AMP, 60-92-4; dexamethasone, 50-02-2; protein bcl 2, 219306-68-0; Biological Markers; Glucocorticoids; Proto-Oncogene Proteins c-bcl-2


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---------- APA ----------
Viegas, L.R., Hoijman, E., Beato, M. & Pecci, A. (2008) . Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids. Journal of Steroid Biochemistry and Molecular Biology, 109(3-5), 273-278.
---------- CHICAGO ----------
Viegas, L.R., Hoijman, E., Beato, M., Pecci, A. "Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids" . Journal of Steroid Biochemistry and Molecular Biology 109, no. 3-5 (2008) : 273-278.
---------- MLA ----------
Viegas, L.R., Hoijman, E., Beato, M., Pecci, A. "Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids" . Journal of Steroid Biochemistry and Molecular Biology, vol. 109, no. 3-5, 2008, pp. 273-278.
---------- VANCOUVER ----------
Viegas, L.R., Hoijman, E., Beato, M., Pecci, A. Mechanisms involved in tissue-specific apopotosis regulated by glucocorticoids. J. Steroid Biochem. Mol. Biol. 2008;109(3-5):273-278.