Artículo

Benencia, F.; Gamba, G.; Benedetti, R.; Courrèges, M.C.; Cavalieri, H.; Massouh, E.J. "Effect of undernourishment on Herpes Simplex Virus Type 1 ocular infection in the Wistar rat model" (2002) International Journal of Experimental Pathology. 83(2):57-66
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Abstract:

We have studied the susceptibility to Herpes Simplex Virus Type 1 (HSV-1) infection in malnourished rats. Groups of 10 rats were undernourished during suckling by offspring duplication. The animals were put on commercial diet and at 1, 2, 3, 5 and 8 weeks after weaning, infected in the eye by scarification with HSV-1, strain F. Significant differences in morbidity and mortality were observed between malnourished and control groups infected three weeks after weaning. Viral titres were higher in ocular washings and brains obtained from the malnourished group. This group showed a diminution in antigen dependent lymphocyte proliferation compared to control, and significantly lower delayed type hypersensitivity reaction against inactivated virus (malnourished = 0.16 ± 0.02 mm, control = 0.26 ± 0.03 mm, p < 0.05). Neutralizing antibodies in serum were lower in the malnourished group and lower levels of interferon were obtained in the malnourished group 24 h post-infection. We conclude that malnutrition during suckling induces a delay in the capability to overcome HSV infection.

Registro:

Documento: Artículo
Título:Effect of undernourishment on Herpes Simplex Virus Type 1 ocular infection in the Wistar rat model
Autor:Benencia, F.; Gamba, G.; Benedetti, R.; Courrèges, M.C.; Cavalieri, H.; Massouh, E.J.
Filiación:Laboratory of Immunochemistry, Department of Biological Chemistry, University of Buenos Aires, Argentina
Experimental Pathology, Department of Pathology, University of Buenos Aires, Argentina
Laboratorio de Inmunoquimica, Depto. Qca. Biologica, Cuidad Universitaria, Nunez (1428), Buenos Aires, Argentina
Palabras clave:Herpes simplex keratitis; Host-defense system; Malnutrition; Viral infection; article; controlled study; diet; disease predisposition; gene duplication; herpes simplex; Herpes simplex virus 1; hypersensitivity; lymphocyte proliferation; malnutrition; nonhuman; priority journal; progeny; rat; rat strain; scar formation; suckling; virus strain; weaning; Animals; Antibodies, Viral; Body Weight; Brain; Disease Progression; Disease Susceptibility; Herpesvirus 1, Human; Hypersensitivity, Delayed; Immunity, Cellular; Keratitis, Herpetic; Nutrition Disorders; Opportunistic Infections; Rats; Rats, Wistar
Año:2002
Volumen:83
Número:2
Página de inicio:57
Página de fin:66
DOI: http://dx.doi.org/10.1046/j.1365-2613.2002.00212.x
Título revista:International Journal of Experimental Pathology
Título revista abreviado:Int. J. Exp. Pathol.
ISSN:09599673
CODEN:IJEPE
CAS:Antibodies, Viral
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09599673_v83_n2_p57_Benencia

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Citas:

---------- APA ----------
Benencia, F., Gamba, G., Benedetti, R., Courrèges, M.C., Cavalieri, H. & Massouh, E.J. (2002) . Effect of undernourishment on Herpes Simplex Virus Type 1 ocular infection in the Wistar rat model. International Journal of Experimental Pathology, 83(2), 57-66.
http://dx.doi.org/10.1046/j.1365-2613.2002.00212.x
---------- CHICAGO ----------
Benencia, F., Gamba, G., Benedetti, R., Courrèges, M.C., Cavalieri, H., Massouh, E.J. "Effect of undernourishment on Herpes Simplex Virus Type 1 ocular infection in the Wistar rat model" . International Journal of Experimental Pathology 83, no. 2 (2002) : 57-66.
http://dx.doi.org/10.1046/j.1365-2613.2002.00212.x
---------- MLA ----------
Benencia, F., Gamba, G., Benedetti, R., Courrèges, M.C., Cavalieri, H., Massouh, E.J. "Effect of undernourishment on Herpes Simplex Virus Type 1 ocular infection in the Wistar rat model" . International Journal of Experimental Pathology, vol. 83, no. 2, 2002, pp. 57-66.
http://dx.doi.org/10.1046/j.1365-2613.2002.00212.x
---------- VANCOUVER ----------
Benencia, F., Gamba, G., Benedetti, R., Courrèges, M.C., Cavalieri, H., Massouh, E.J. Effect of undernourishment on Herpes Simplex Virus Type 1 ocular infection in the Wistar rat model. Int. J. Exp. Pathol. 2002;83(2):57-66.
http://dx.doi.org/10.1046/j.1365-2613.2002.00212.x