Abstract:
The aim of this study was to investigate the drug-loading effects on release and mechanical properties of a scleroglucan gel, with the intention of considering them in delivery systems formulations. The rheological and kinetic properties of a 2% w/w scleroglucan gel matrix loaded and 0, 0.02, 0.04, 0.06, 0.2 0.4% w/w of theophylline (Th, used as a model drug) were investigated. Rheological measurements were performed in a controlled-stress rotational-shear rheometer under isothermal conditions. For theophylline release from the gel a flat Franz cell was used and the kinetic parameters were derived applying a semi-empirical power law. The influence of scleroglucan molar weight on kinetic and rheological behaviour was also studied. Results suggest two possible effects of drug loading on the gel network: in the 0.04-0.06% w/ w Th range a plasticizing effect and in the 0.2-0.4% w/w Th range a rigidization effect. In the first range mentioned, the changes in the gel structural properties tested by means of rheological measurements are coincident with changes in drug-release kinetics. © 2005 Society of Chemical Industry.
Registro:
Documento: |
Artículo
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Título: | Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings |
Autor: | François, N.J.; Rojas, A.M.; Daraio, M.E. |
Filiación: | Laboratorio de Química de Sistemas Heterogéneos, Departamento de Química, Facultad de Ingeniería, Paseo Colón 850, C1063ACV Buenos Aires, Argentina Departamento de Industrias, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428EHA Buenos Aires, Argentina
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Palabras clave: | Biopolymer; Drug loading; Drug release; Dynamic rheology; Scleroglucan; Theophylline; Biopolymers; Controlled drug delivery; Materials testing; Molecular structure; Molecular weight; Pharmacokinetics; Rheology; Drug loadings; Drug-release behaviour; Dynamic rheology; Gel structural properties; Scleroglucan gel matrix; Theophylline; Gels; drug delivery |
Año: | 2005
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Volumen: | 54
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Número: | 12
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Página de inicio: | 1613
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Página de fin: | 1619
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DOI: |
http://dx.doi.org/10.1002/pi.1889 |
Título revista: | Polymer International
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Título revista abreviado: | Polym. Int.
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ISSN: | 09598103
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09598103_v54_n12_p1613_Francois |
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Citas:
---------- APA ----------
François, N.J., Rojas, A.M. & Daraio, M.E.
(2005)
. Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings. Polymer International, 54(12), 1613-1619.
http://dx.doi.org/10.1002/pi.1889---------- CHICAGO ----------
François, N.J., Rojas, A.M., Daraio, M.E.
"Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings"
. Polymer International 54, no. 12
(2005) : 1613-1619.
http://dx.doi.org/10.1002/pi.1889---------- MLA ----------
François, N.J., Rojas, A.M., Daraio, M.E.
"Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings"
. Polymer International, vol. 54, no. 12, 2005, pp. 1613-1619.
http://dx.doi.org/10.1002/pi.1889---------- VANCOUVER ----------
François, N.J., Rojas, A.M., Daraio, M.E. Rheological and drug-release behaviour of a scleroglucan gel matrix at different drug loadings. Polym. Int. 2005;54(12):1613-1619.
http://dx.doi.org/10.1002/pi.1889