Artículo

Troncoso, M.F.; Ferragut, F.; Bacigalupo, M.L.; Delgado, V.M.C.; Nugnes, L.G.; Gentilini, L.; Laderach, D.; Wolfenstein-Todel, C.; Compagno, D.; Rabinovich, G.A.; Elola, M.T. "Galectin-8: A matricellular lectin with key roles in angiogenesis" (2014) Glycobiology. 24(10):907-914
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Abstract:

Galectin-8 (gal-8) is a "tandem-repeat"-type galectin, containing two carbohydrate recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm and nucleus in vascular endothelial cells (ECs) from normal and tumor-associated blood vessels, and in lymphatic endothelial cells. Herein, we describe a novel role for gal-8 in the regulation of vascular and lymphatic angiogenesis and provide evidence of its critical implications in tumor biology. Functional assays revealed central roles for gal-8 in the control of capillary-tube formation, EC migration and in vivo angiogenesis. So far, two endothelial ligands have been described for gal-8, namely podoplanin in lymphatic vessels and CD166 (ALCAM, activated leukocyte cell adhesion molecule) in vascular ECs. Other related gal-8 functions are also summarized here, including cell adhesion and migration, which collectively demonstrate the multi-functionality of this complex lectin. Thus, gal-8 is an important component of the angiogenesis network, and an essential molecule in the extracellular matrix by providing molecular anchoring to this surrounding matrix. The implications of gal-8 in tumor angiogenesis remain to be further explored, but it is exciting to speculate that modulating gal-8-glycan interactions could be used to block lymphatic-vascular connections vital for metastasis. © The Author 2014. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Registro:

Documento: Artículo
Título:Galectin-8: A matricellular lectin with key roles in angiogenesis
Autor:Troncoso, M.F.; Ferragut, F.; Bacigalupo, M.L.; Delgado, V.M.C.; Nugnes, L.G.; Gentilini, L.; Laderach, D.; Wolfenstein-Todel, C.; Compagno, D.; Rabinovich, G.A.; Elola, M.T.
Filiación:Instituto de Química y Fisicoquímica Biológicas Prof. Dr. Alejandro Paladini (UBA-CONICET), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina
Laboratorio de Glicómica Funcional, IQUIBICEN-CONICET, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME - CONICET), Buenos Aires, Argentina
Palabras clave:Angiogenesis; CD166; Endothelium; Galectin-8; activated leukocyte cell adhesion molecule; galectin 8; Hermes antigen; integrin; podoplanin; ALCAM protein, human; fetoprotein; galectin; leukocyte antigen; LGALS8 protein, human; membrane protein; nerve cell adhesion molecule; PDPN protein, human; angiogenesis; Article; cell adhesion; cell migration; endothelium cell; human; lymph vessel endothelium; lymphangiogenesis; nonhuman; priority journal; protein protein interaction; serum; vascular endothelium; carcinogenesis; extracellular matrix; genetics; metabolism; metastasis; neoplasm; neovascularization (pathology); pathology; Antigens, CD; Carcinogenesis; Cell Adhesion; Cell Adhesion Molecules, Neuronal; Endothelial Cells; Extracellular Matrix; Fetal Proteins; Galectins; Humans; Membrane Glycoproteins; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic
Año:2014
Volumen:24
Número:10
Página de inicio:907
Página de fin:914
DOI: http://dx.doi.org/10.1093/glycob/cwu054
Título revista:Glycobiology
Título revista abreviado:Glycobiology
ISSN:09596658
CODEN:GLYCE
CAS:galectin 8, 220452-97-1; ALCAM protein, human; Antigens, CD; Cell Adhesion Molecules, Neuronal; Fetal Proteins; Galectins; LGALS8 protein, human; Membrane Glycoproteins; PDPN protein, human
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09596658_v24_n10_p907_Troncoso

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Citas:

---------- APA ----------
Troncoso, M.F., Ferragut, F., Bacigalupo, M.L., Delgado, V.M.C., Nugnes, L.G., Gentilini, L., Laderach, D.,..., Elola, M.T. (2014) . Galectin-8: A matricellular lectin with key roles in angiogenesis. Glycobiology, 24(10), 907-914.
http://dx.doi.org/10.1093/glycob/cwu054
---------- CHICAGO ----------
Troncoso, M.F., Ferragut, F., Bacigalupo, M.L., Delgado, V.M.C., Nugnes, L.G., Gentilini, L., et al. "Galectin-8: A matricellular lectin with key roles in angiogenesis" . Glycobiology 24, no. 10 (2014) : 907-914.
http://dx.doi.org/10.1093/glycob/cwu054
---------- MLA ----------
Troncoso, M.F., Ferragut, F., Bacigalupo, M.L., Delgado, V.M.C., Nugnes, L.G., Gentilini, L., et al. "Galectin-8: A matricellular lectin with key roles in angiogenesis" . Glycobiology, vol. 24, no. 10, 2014, pp. 907-914.
http://dx.doi.org/10.1093/glycob/cwu054
---------- VANCOUVER ----------
Troncoso, M.F., Ferragut, F., Bacigalupo, M.L., Delgado, V.M.C., Nugnes, L.G., Gentilini, L., et al. Galectin-8: A matricellular lectin with key roles in angiogenesis. Glycobiology. 2014;24(10):907-914.
http://dx.doi.org/10.1093/glycob/cwu054