Artículo

Compagno, D.; Gentilini, L.D.; Jaworski, F.M.; Pérez, I.G.; Contrufo, G.; Laderach, D.J. "Glycans and galectins in prostate cancer biology, angiogenesis and metastasis" (2014) Glycobiology. 24(10):899-906
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Abstract:

Prostate cancer is the second most common cause of cancer and the sixth leading cause of cancer death among men worldwide. While localized prostate cancer can be cured, advanced and metastatic prostate cancer remains a significant therapeutic challenge. Malignant transformation is associated with important modifications of the cellular glycosylation profile, and it is postulated that these changes have a considerable relevance for tumor biology. Metastasis is a multiphasic process that encompasses angiogenesis, the spread of tumor cells and their growth at distant sites from the primary tumor location. Recognition of glycoconjugates by galectins, among other lectins, plays a fundamental role in the metastatic spread, tumor immune escape and the neovascularization process. Particularly in prostate cancer, both carbohydrates and galectins have been implicated in many cellular processes such as proliferation, apoptosis, migration and invasion. However, a limited number of studies assessed their potential implications in the induction of metastasis in prostate cancer patients or in animal models. Moreover, the role of galectin-glycan interactions in vivo still remains poorly understood; concerted effort should thus be made in order to shed some light on this question. This review summarizes current evidence on both the expression and role of glycans and galectins in prostate cancer, particularly turning our attention to the angiogenic and metastatic processes. © The Author 2014. Published by Oxford University Press. All rights reserved.

Registro:

Documento: Artículo
Título:Glycans and galectins in prostate cancer biology, angiogenesis and metastasis
Autor:Compagno, D.; Gentilini, L.D.; Jaworski, F.M.; Pérez, I.G.; Contrufo, G.; Laderach, D.J.
Filiación:Structural and Functional Glycomics Laboratory, IQUIBICEN-CONICET, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Angiogenesis and metastasis; Carbohydrate; Galectin; Glycan; Prostate tumor; galectin; galectin 1; galectin 3; galectin 8; glycan; glycoconjugate; lectin; galectin; polysaccharide; angiogenesis; apoptosis; cell invasion; cell migration; cell proliferation; glycosylation; human; metastasis; nonhuman; primary tumor; priority journal; prostate cancer; protein expression; Review; tumor cell; cell motion; gene expression regulation; genetics; male; metabolism; metastasis; neovascularization (pathology); pathology; prostate tumor; Apoptosis; Cell Movement; Cell Proliferation; Galectins; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasm Metastasis; Neovascularization, Pathologic; Polysaccharides; Prostatic Neoplasms
Año:2014
Volumen:24
Número:10
Página de inicio:899
Página de fin:906
DOI: http://dx.doi.org/10.1093/glycob/cwu055
Título revista:Glycobiology
Título revista abreviado:Glycobiology
ISSN:09596658
CODEN:GLYCE
CAS:galectin 1, 258495-34-0; galectin 3, 208128-56-7; galectin 8, 220452-97-1; Galectins; Polysaccharides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09596658_v24_n10_p899_Compagno

Referencias:

  • Ahmed, H., Banerjee, P.P., Vasta, G.R., Differential expression of galectins in normal, benign and malignant prostate epithelial cells: Silencing of galectin-3 expression in prostate cancer by its promoter methylation (2007) Biochem Biophys Res Commun., 358, pp. 241-246
  • Balan, V., Nangia-Makker, P., Kho, D.H., Wang, Y., Raz, A., Tyrosine-phosphorylated galectin-3 protein is resistant to prostate-specific antigen (Psa) cleavage (2012) J Biol Chem., 287, pp. 5192-5198
  • Barthel, S.R., Gavino, J.D., Wiese, G.K., Jaynes, J.M., Siddiqui, J., Dimitroff, C.J., Analysis of glycosyltransferase expression in metastatic prostate cancer cells capable of rolling activity on microvascular endothelial (E)-selectin (2008) Glycobiology, 18, pp. 806-817
  • Brockhausen, I., Pathways of O-glycan biosynthesis in cancer cells (1999) Biochim Biophys Acta, 1473, pp. 67-95
  • Brooks, S.A., Hall, D.M., Lectin histochemistry to detect altered glycosylation in cells and tissues (2012) Methods Mol Biol., 878, pp. 31-50
  • Califice, S., Castronovo, V., Bracke, M., Van Den Brule, F., Dual activities of galectin-3 in human prostate cancer: Tumor suppression of nuclear galectin-3 vs tumor promotion of cytoplasmic galectin-3 (2004) Oncogene., 23, pp. 7527-7536
  • Chauchereau, A., Experimental models for the development of new medical treatments in prostate cancer (2011) Eur J Cancer, 47, pp. S200-S214
  • Clausse, N., Van Den Brule, F., Waltregny, D., Garnier, F., Castronovo, V., Galectin-1 expression in prostate tumor-associated capillary endothelial cells is increased by prostate carcinoma cells and modulates heterotypic cell-cell adhesion (1999) Angiogenesis., 3, pp. 317-325
  • Compagno, D., Jaworski, F.M., Gentilini, L., Contrufo, G., Gonzalez-Perez, I., Elola, M.T., Rabinovich, G.A., Laderach, D.J., Galectins: Major signaling modulators inside and outside the cell (2014) Curr Mol Med., , [Epub ahead of print]
  • Compagno, D., Laderach, D.J., Gentilini, L., Jaworski, F.M., Rabinovich, G.A., Delineating the "galectin signature" of tumor microenvironment (2013) Oncoimmunology, 2
  • Compagno, D., Merle, C., Morin, A., Gilbert, C., Mathieu, J., Bozec, A., Mauduit, C., Cabon, F., Sirna-directed in vivo silencing of androgen receptor inhibits the growth of castration-resistant prostate carcinomas (2007) PLoS ONE, 2
  • Croci, D.O., Cerliani, J.P., Dalotto-Moreno, T., Mendez-Huergo, S.P., Mascanfroni, I.D., Dergan-Dylon, S., Toscano, M.A., Ouyang, J., Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors (2014) Cell, 156, pp. 744-758
  • Croci, D.O., Salatino, M., Rubinstein, N., Cerliani, J.P., Cavallin, L.E., Leung, H.J., Ouyang, J., Domaica, C.I., Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in kaposi's sarcoma (2012) J Exp Med., 209, pp. 1985-2000
  • Cueni, L.N., Detmar, M., Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions (2009) Exp Cell Res., 315, pp. 1715-1723
  • Dalziel, M., Crispin, M., Scanlan, C.N., Zitzmann, N., Dwek, R.A., Emerging principles for the therapeutic exploitation of glycosylation (2014) Science, 343
  • Delgado, V.M., Nugnes, L.G., Colombo, L.L., Troncoso, M.F., Fernandez, M.M., Malchiodi, E.L., Frahm, I., Rabinovich, G.A., Modulation of endothelial cell migration and angiogenesis: A novel function for the "Tandem-repeat" lectin galectin-8 (2011) FASEB J., 25, pp. 242-254
  • Denmeade, S.R., Isaacs, J.T., A history of prostate cancer treatment (2002) Nat Rev Cancer, 2, pp. 389-396
  • D'Haene, N., Sauvage, S., Maris, C., Adanja, I., Le Mercier, M., Decaestecker, C., Baum, L., Salmon, I., Vegfr1 and vegfr2 involvement in extracellular galectin-1- and galectin-3-induced angiogenesis (2013) PLoS ONE, 8
  • Di Lella, S., Sundblad, V., Cerliani, J.P., Guardia, C.M., Estrin, D.A., Vasta, G.R., Rabinovich, G.A., When galectins recognize glycans: From biochemistry to physiology and back again (2011) Biochemistry, 50, pp. 7842-7857
  • Dube, D.H., Bertozzi, C.R., Glycans in cancer and inflammation - Potential for therapeutics and diagnostics (2005) Nat Rev Drug Discov., 4, pp. 477-488
  • Ellerhorst, J., Nguyen, T., Cooper, D.N., Lotan, D., Lotan, R., Differential expression of endogenous galectin-1 and galectin-3 in human prostate cancer cell lines and effects of overexpressing galectin-1 on cell phenotype (1999) Int J Oncol., 14, pp. 217-224
  • Ellerhorst, J., Troncoso, P., Xu, X.C., Lee, J., Lotan, R., Galectin-1 and galectin-3 expression in human prostate tissue and prostate cancer (1999) Urol Res., 27, pp. 362-367
  • Fry, S., Afrough, B., Leathem, A., Dwek, M., Lectin array-based strategies for identifying metastasis-associated changes in glycosylation (2012) Methods Mol Biol., 878, pp. 267-272
  • Fukumori, T., Kanayama, H.-O., Raz, A., The role of galectin-3 in cancer drug resistance (2007) Drug Resist Updates, 10, pp. 101-108
  • Fukushima, K., Satoh, T., Baba, S., Yamashita, K., Alpha1,2-fucosylated and beta-N-acetylgalactosaminylated prostate-specific antigen as an efficient marker of prostatic cancer (2010) Glycobiology, 20, pp. 452-460
  • Geney, R., Ungureanu, I.M., Li, D., Ojima, I., Overcoming multidrug resistance in taxane chemotherapy (2002) Clin Chem Lab Med., 40, pp. 918-925
  • Gilgunn, S., Conroy, P.J., Saldova, R., Rudd, P.M., O'Kennedy, R.J., Aberrant psa glycosylation - A sweet predictor of prostate cancer (2013) Nat Rev Urol., 10, pp. 99-107
  • Gleason, D.F., Histologic grade, clinical stage, and patient age in prostate cancer (1988) NCIMonogr., pp. 15-18
  • Glinskii, O.V., Huxley, V.H., Glinsky, G.V., Pienta, K.J., Raz, A., Glinsky, V.V., Mechanical entrapment is insufficient and intercellular adhesion is essential for metastatic cell arrest in distant organs (2005) Neoplasia., 7, pp. 522-527
  • Glinskii, O.V., Li, F., Wilson, L.S., Barnes, S., Rittenhouse-Olson, K., Barchi, J.J., Jr., Pienta, K.J., Glinsky, V.V., Endothelial integrin alpha3beta1 stabilizes carbohydrate-mediated tumor/endothelial cell adhesion and induces macro-molecular signaling complex formation at the endothelial cell membrane (2014) Oncotarget., 5, pp. 1382-1389
  • Glinskii, O.V., Sud, S., Mossine, V.V., Mawhinney, T.P., Anthony, D.C., Glinsky, G.V., Pienta, K.J., Glinsky, V.V., Inhibition of prostate cancer bone metastasis by synthetic tf antigen mimic/Galectin-3 inhibitor lactulose-L-leucine (2012) Neoplasia., 14, pp. 65-73
  • Glinsky, V.V., Glinsky, G.V., Rittenhouse-Olson, K., Huflejt, M.E., Glinskii, O.V., Deutscher, S.L., Quinn, T.P., The role of thomsen-friedenreich antigen in adhesion of human breast and prostate cancer cells to the endothelium (2001) Cancer Res., 61, pp. 4851-4857
  • Glinsky, V.V., Glinsky, G.V., Glinskii, O.V., Huxley, V.H., Turk, J.R., Mossine, V.V., Deutscher, S.L., Quinn, T.P., Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium (2003) Cancer Res., 63, pp. 3805-3811
  • Glinsky, V.V., Kiriakova, G., Glinskii, O.V., Mossine, V.V., Mawhinney, T.P., Turk, J.R., Glinskii, A.B., Glinsky, G.V., Synthetic galectin-3 inhibitor increases metastatic cancer cell sensitivity to taxol-induced apoptosis in vitro and in vivo (2009) Neoplasia., 11, pp. 901-909
  • Glinsky, G.V., Mossine, V.V., Price, J.E., Bielenberg, D., Glinsky, V.V., Ananthaswamy, H.N., Feather, M.S., Inhibition of colony formation in agarose of metastatic human breast carcinoma and melanoma cells by synthetic glycoamine analogs (1996) Clin Exp Metastasis, 14, pp. 253-267
  • Grabowska, M.M., Degraff, D.J., Yu, X., Jin, R.J., Chen, Z., Borowsky, A.D., Matusik, R.J., Mouse models of prostate cancer: Picking the best model for the question (2014) Cancer Metastasis Rev., , PMID: 24452759. [Epub ahead of print]
  • Guha, P., Kaptan, E., Bandyopadhyaya, G., Kaczanowska, S., Davila, E., Thompson, K., Martin, S.S., Ahmed, H., Cod glycopeptide with picomolar affinity to galectin-3 suppresses T-cell apoptosis and prostate cancer metastasis (2013) Proc Natl Acad Sci USA, 110, pp. 5052-5057
  • Hadari, Y.R., Arbel-Goren, R., Levy, Y., Amsterdam, A., Alon, R., Zakut, R., Zick, Y., Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis (2000) J Cell Sci., 113, pp. 2385-2397
  • Hauselmann, I., Borsig, L., Altered tumor-cell glycosylation promotes metastasis (2014) Front Oncol., 4, p. 28
  • He, J., Baum, L.G., Endothelial cell expression of galectin-1 induced by prostate cancer cells inhibits T-cell transendothelial migration (2006) Lab Invest., 86, pp. 578-590
  • Heimburg, J., Yan, J., Morey, S., Glinskii, O.V., Huxley, V.H., Wild, L., Klick, R., Rittenhouse-Olson, K., Inhibition of spontaneous breast cancer metastasis by anti-thomsen-friedenreich antigen monoclonal antibody jaa-F11 (2006) Neoplasia., 8, pp. 939-948
  • Jemal, A., Bray, F., Center, M.M., Ferlay, J., Ward, E., Forman, D., Global cancer statistics (2011) CA Cancer J Clin., 61, pp. 69-90
  • Johnson, K.D., Glinskii, O.V., Mossine, V.V., Turk, J.R., Mawhinney, T.P., Anthony, D.C., Henry, C.J., Pienta, K.J., Galectin-3 as a potential therapeutic target in tumors arising from malignant endothelia (2007) Neoplasia., 9, pp. 662-670
  • Kamigaito, T., Okaneya, T., Kawakubo, M., Shimojo, H., Nishizawa, O., Nakayama, J., Overexpression of O-glcnac by prostate cancer cells is significantly associated with poor prognosis of patients (2014) Prostate Cancer Prostatic Dis., 17, pp. 18-22
  • Knapp, J.S., Lokeshwar, S.D., Vogel, U., Hennenlotter, J., Schwentner, C., Kramer, M.W., Stenzl, A., Merseburger, A.S., Galectin-3 expression in prostate cancer and benign prostate tissues: Correlation with biochemical recurrence (2013) World J Urol., 31, pp. 351-358
  • Laderach, D.J., Compagno, D., Toscano, M.A., Croci, D.O., Dergan-Dylon, S., Salatino, M., Rabinovich, G.A., Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings (2010) IUBMB Life, 62, pp. 1-13
  • Laderach, D.J., Gentilini, L.D., Giribaldi, L., Delgado, V.C., Nugnes, L., Croci, D.O., Al Nakouzi, N., Mazza, O., A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease (2013) Cancer Res., 73, pp. 86-96
  • Lange, T., Ullrich, S., Muller, I., Nentwich, M.F., Stubke, K., Feldhaus, S., Knies, C., Abramjuk, C., Human prostate cancer in a clinically relevant xenograft mouse model: Identification of beta(1,6)-branched oligosaccharides as a marker of tumor progression (2012) Clin Cancer Res., 18, pp. 1364-1373
  • Lee, S.H., Hatakeyama, S., Yu, S.Y., Bao, X., Ohyama, C., Khoo, K.H., Fukuda, M.N., Fukuda, M., Core3 O-glycan synthase suppresses tumor formation and metastasis of prostate carcinoma pc3 and lncap cells through down-regulation of alpha2beta1 integrin complex (2009) J Biol Chem., 284, pp. 17157-17169
  • Lehr, J.E., Pienta, K.J., Preferential adhesion of prostate cancer cells to a human bone marrow endothelial cell line (1998) J Natl Cancer Inst., 90, pp. 118-123
  • Levy, Y., Arbel-Goren, R., Hadari, Y.R., Eshhar, S., Ronen, D., Elhanany, E., Geiger, B., Zick, Y., Galectin-8 functions as a matricellular modulator of cell adhesion (2001) J Biol Chem., 276, pp. 31285-31295
  • Levy, Y., Ronen, D., Bershadsky, A.D., Zick, Y., Sustained induction of erk, protein kinase B, and P70 S6 kinase regulates cell spreading and formation of F-actin microspikes upon ligation of integrins by galectin-8, a mammalian lectin (2003) J Biol Chem., 278, pp. 14533-14542
  • Li, J., Guillebon, A.D., Hsu, J.W., Barthel, S.R., Dimitroff, C.J., Lee, Y.F., King, M.R., Human fucosyltransferase 6 enables prostate cancer metastasis to bone (2013) Br J Cancer, 109, pp. 3014-3022
  • Liu, F.T., Rabinovich, G.A., Galectins as modulators of tumour progression (2005) Nat Rev Cancer, 5, pp. 29-41
  • Liu, X., Yang, P., Hart, G., O-glcnacylation modifies the metastatic properties of prostate cancer cells (2014) FASEB J., 28, pp. 789-795
  • Lynch, T.P., Ferrer, C.M., Jackson, S.R., Shahriari, K.S., Vosseller, K., Reginato, M.J., Critical role of O-linked beta-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis (2012) J Biol Chem., 287, pp. 11070-11081
  • Mariño, K., Bones, J., Kattla, J.J., Rudd, P.M., A systematic approach to protein glycosylation analysis: A path through the maze (2010) Nat Chem Biol., 6, pp. 713-723
  • Markowska, A.I., Liu, F.T., Panjwani, N., Galectin-3 is an important mediator of Vegf- and Bfgf-mediated angiogenic response (2011) J Exp Med., 207, pp. 1981-1993
  • Mechref, Y., Hu, Y., Garcia, A., Zhou, S., Desantos-Garcia, J.L., Hussein, A., Defining putative glycan cancer biomarkers by ms (2012) Bioanalysis., 4, pp. 2457-2469
  • Merseburger, A.S., Kramer, M.W., Hennenlotter, J., Simon, P., Knapp, J., Hartmann, J.T., Stenzl, A., Kuczyk, M.A., Involvement of decreased galectin-3 expression in the pathogenesis and progression of prostate cancer (2008) Prostate, 68, pp. 72-77
  • Miller, V., Interpretation of resistance assay results (2001) Antivir Ther., 6, pp. 1-9
  • Nangia-Makker, P., Hogan, V., Honjo, Y., Baccarini, S., Tait, L., Bresalier, R., Raz, A., Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin (2002) J Natl Cancer Inst., 94, pp. 1854-1862
  • Nangia-Makker, P., Honjo, Y., Sarvis, R., Akahani, S., Hogan, V., Pienta, K.J., Raz, A., Galectin-3 induces endothelial cell morphogenesis and angiogenesis (2000) Am J Pathol., 156, pp. 899-909
  • Nangia-Makker, P., Wang, Y., Raz, T., Tait, L., Balan, V., Hogan, V., Raz, A., Cleavage of galectin-3 by matrix metalloproteases induces angiogenesis in breast cancer (2010) Int J Cancer, 127, pp. 2530-2541
  • Ohyama, C., Hosono, M., Nitta, K., Oh-Eda, M., Yoshikawa, K., Habuchi, T., Arai, Y., Fukuda, M., Carbohydrate structure and differential binding of prostate specific antigen to maackia amurensis lectin between prostate cancer and benign prostate hypertrophy (2004) Glycobiology, 14, pp. 671-679
  • Okamoto, T., Yoneyama, M.S., Hatakeyama, S., Mori, K., Yamamoto, H., Koie, T., Saitoh, H., Fukuda, M., Core2 O-glycan-expressing prostate cancer cells are resistant to nk cell immunity (2013) Mol Med Rep., 7, pp. 359-364
  • Packer, N.H., Von Der Lieth, C.W., Aoki-Kinoshita, K.F., Lebrilla, C.B., Paulson, J.C., Raman, R., Rudd, P., York, W.S., Frontiers in glycomics: Bioinformatics and biomarkers in disease. An nih white paper prepared from discussions by the focus groups at a workshop on the nih campus, bethesda, MD (September 11-13, 2006) (2008) Proteomics., 8, pp. 8-20
  • Peracaula, R., Tabares, G., Royle, L., Harvey, D.J., Dwek, R.A., Rudd, P.M., De Llorens, R., Altered glycosylation pattern allows the distinction between prostate-specific antigen (Psa) from normal and tumor origins (2003) Glycobiology, 13, pp. 457-470
  • Petrylak, D.P., The current role of chemotherapy in metastatic hormone-refractory prostate cancer (2005) Urology, 65, pp. 3-7. , discussion 7-8
  • Petrylak, D.P., Tangen, C.M., Hussain, M.H., Lara, P.N., Jr., Jones, J.A., Taplin, M.E., Burch, P.A., Kohli, M., Docetaxel and estra-mustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer (2004) NEngl JMed., 351, pp. 1513-1520
  • Pienta, K.J., Loberg, R., The "emigration, migration, and immigration" of prostate cancer (2005) Clin Prostate Cancer, 4, pp. 24-30
  • Pienta, K.J., Naik, H., Akhtar, A., Yamazaki, K., Replogle, T.S., Lehr, J., Donat, T.L., Raz, A., Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin (1995) J Natl Cancer Inst., 87, pp. 348-353
  • Rabinovich, G.A., Croci, D.O., Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer (2012) Immunity, 36, pp. 322-335
  • Rabinovich, G.A., Toscano, M.A., Turning "Sweet" on immunity: Galectin-glycan interactions in immune tolerance and inflammation (2009) Nat Rev Immunol., 9, pp. 338-352
  • Roodman, G.D., Mechanisms of bone metastasis (2004) Discov Med., 4, pp. 144-148
  • Saldova, R., Fan, Y., Fitzpatrick, J.M., Watson, R.W., Rudd, P.M., Core fucosylation and alpha2-3 sialylation in serum N-glycome is significantly increased in prostate cancer comparing to benign prostate hyperplasia (2011) Glycobiology, 21, pp. 195-205
  • Saraswati, S., Block, A.S., Davidson, M.K., Rank, R.G., Mahadevan, M., Diekman, A.B., Galectin-3 is a substrate for prostate specific antigen (Psa) in human seminal plasma (2011) Prostate, 71, pp. 197-208
  • Slovin, S.F., Ragupathi, G., Musselli, C., Olkiewicz, K., Verbel, D., Kuduk, S.D., Schwarz, J.B., Livingston, P.O., Fully synthetic carbohydrate-based vaccines in biochemically relapsed prostate cancer: Clinical trial results with alpha-N-acetylgalactosamine-O-serine/threonine conjugate vaccine (2003) J Clin Oncol., 21, pp. 4292-4298
  • Su, Z.Z., Lin, J., Shen, R., Fisher, P.E., Goldstein, N.I., Fisher, P.B., Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene pcta-1 a member of the galectin gene family (1996) Proc Natl Acad Sci USA, 93, pp. 7252-7257
  • Tannock, I.F., De Wit, R., Berry, W.R., Horti, J., Pluzanska, A., Chi, K.N., Oudard, S., Turesson, I., Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer (2004) N Engl J Med., 351, pp. 1502-1512
  • Thijssen, V.L., Barkan, B., Shoji, H., Aries, I.M., Mathieu, V., Deltour, L., Hackeng, T.M., Poirier, F., Tumor cells secrete galectin-1 to enhance endothelial cell activity (2010) Cancer Res., 70, pp. 6216-6224
  • Thijssen, V.L., Postel, R., Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Verhofstad, N., Bakkers, J., Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy (2006) Proc Natl Acad Sci USA, 103, pp. 15975-15980
  • Valenzuela, H.F., Pace, K.E., Cabrera, P.V., White, R., Porvari, K., Kaija, H., Vihko, P., Baum, L.G., O-glycosylation regulates lncap prostate cancer cell susceptibility to apoptosis induced by galectin-1 (2007) Cancer Res., 67, pp. 6155-6162
  • Van Den Brule, F.A., Waltregny, D., Waltregny, D., Liu, F.T., Castronovo, V., Alteration of the cytoplasmic/nuclear expression pattern of galectin-3 correlates with prostate carcinoma progression (2000) Int J Cancer, 89, pp. 361-367
  • Van Kooyk, Y., Rabinovich, G.A., Protein-glycan interactions in the control of innate and adaptive immune responses (2008) Nat Immunol., 9, pp. 593-601
  • Wang, Y., Balan, V., Gao, X., Reddy, P.G., Kho, D., Tait, L., Raz, A., The significance of galectin-3 as a new basal cell marker in prostate cancer (2013) Cell Death Dis., 4, p. e753
  • Wang, Y., Nangia-Makker, P., Tait, L., Balan, V., Hogan, V., Pienta, K.J., Raz, A., Regulation of prostate cancer progression by galectin-3 (2009) Am J Pathol., 174, pp. 1515-1523
  • Yin, X., Rana, K., Ponmudi, V., King, M.R., Knockdown of fucosyltransferase III disrupts the adhesion of circulating cancer cells to E-selectin without affecting hematopoietic cell adhesion (2010) Carbohydr Res., 345, pp. 2334-2342
  • Yu, L.G., Andrews, N., Zhao, Q., McKean, D., Williams, J.F., Connor, L.J., Gerasimenko, O.V., Kasai, K., Galectin-3 interaction with thomsen-friedenreich disaccharide on cancer-associated muc1 causes increased cancer cell endothelial adhesion (2007) J Biol Chem., 282, pp. 773-781
  • Zhao, Q., Barclay, M., Hilkens, J., Guo, X., Barrow, H., Rhodes, J.M., Yu, L.G., Interaction between circulating galectin-3 and cancer-associated muc1 enhances tumour cell homotypic aggregation and prevents anoikis (2010) Mol Cancer, 9, p. 154
  • Zhuo, Y., Chammas, R., Bellis, S.L., Sialylation of beta1 integrins blocks cell adhesion to galectin-3 and protects cells against galectin-3-induced apoptosis (2008) J Biol Chem., 283, pp. 22177-22185
  • Zick, Y., Eisenstein, M., Goren, R.A., Hadari, Y.R., Levy, Y., Ronen, D., Role of galectin-8 as a modulator of cell adhesion and cell growth (2004) Glycoconj J., 19, pp. 517-526
  • Zou, J., Glinsky, V.V., Landon, L.A., Matthews, L., Deutscher, S.L., Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion (2005) Carcinogenesis, 26, pp. 309-318

Citas:

---------- APA ----------
Compagno, D., Gentilini, L.D., Jaworski, F.M., Pérez, I.G., Contrufo, G. & Laderach, D.J. (2014) . Glycans and galectins in prostate cancer biology, angiogenesis and metastasis. Glycobiology, 24(10), 899-906.
http://dx.doi.org/10.1093/glycob/cwu055
---------- CHICAGO ----------
Compagno, D., Gentilini, L.D., Jaworski, F.M., Pérez, I.G., Contrufo, G., Laderach, D.J. "Glycans and galectins in prostate cancer biology, angiogenesis and metastasis" . Glycobiology 24, no. 10 (2014) : 899-906.
http://dx.doi.org/10.1093/glycob/cwu055
---------- MLA ----------
Compagno, D., Gentilini, L.D., Jaworski, F.M., Pérez, I.G., Contrufo, G., Laderach, D.J. "Glycans and galectins in prostate cancer biology, angiogenesis and metastasis" . Glycobiology, vol. 24, no. 10, 2014, pp. 899-906.
http://dx.doi.org/10.1093/glycob/cwu055
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Compagno, D., Gentilini, L.D., Jaworski, F.M., Pérez, I.G., Contrufo, G., Laderach, D.J. Glycans and galectins in prostate cancer biology, angiogenesis and metastasis. Glycobiology. 2014;24(10):899-906.
http://dx.doi.org/10.1093/glycob/cwu055