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Abstract:

We have studied the effects of spinal cord transection and of dexamethasone (DEX) treatment on mRNA biosynthesis of the Na+,K+-ATPase, a key enzyme necessary for neurotransmission, membrane repolarization and nutrient uptake in the CNS. In situ hybridization analysis revealed a significant reduction in mRNA for the α3 catalytic subunit of the enzyme in medium and large size ventral horn neurones (1000-2300 μm2) but not in small cells (1000 μm2) 24 h after spinal cord transection. DEX treatment significantly reversed the transection effect in medium and large size neurones. It is suggested that up-regulation of mRNA expression for Na+,K+- ATPase may constitute an important mechanism by which glucocorticoids help to re-establish neuronal function after spinal cord injury.

Registro:

Documento: Artículo
Título:Dexamethasone up-regulates mRNA for Na+,K+-ATPase in some spinal cord neurones after cord transection
Autor:Gonzalez, S.; Grillo, C.; Gonzalez Deniselle, M.C.; Lima, A.; McEwen, B.S.; De Nicola, A.F.
Filiación:Faculty of Medicine, University of Buenos Aires, Obligado 2490, 1428 Buenos Aires, Argentina
Lab. of Neuroendocrine Biochemistry, Inst. de Biol. y Med. Experimetal, Obligado 2490, 1428 Buenos Aires, Argentina
Rockefeller University, New York, NY, United States
Palabras clave:CNS injury; Dexamethasone; Glucocorticoid; In situ hybridization; Na+,K+-ATPase; Spinal cord; adenosine triphosphatase (potassium sodium); dexamethasone; messenger RNA; animal model; animal tissue; article; controlled study; enzyme active site; in situ hybridization; male; messenger RNA synthesis; nonhuman; priority journal; rat; spinal cord injury; spinal cord nerve cell; spinal cord transsection; spinal cord ventral horn; subcutaneous drug administration
Año:1996
Volumen:7
Número:5
Página de inicio:1041
Página de fin:1044
DOI: http://dx.doi.org/10.1097/00001756-199604100-00017
Título revista:NeuroReport
Título revista abreviado:NEUROREPORT
ISSN:09594965
CODEN:NERPE
CAS:adenosine triphosphatase (potassium sodium); dexamethasone, 50-02-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09594965_v7_n5_p1041_Gonzalez

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Citas:

---------- APA ----------
Gonzalez, S., Grillo, C., Gonzalez Deniselle, M.C., Lima, A., McEwen, B.S. & De Nicola, A.F. (1996) . Dexamethasone up-regulates mRNA for Na+,K+-ATPase in some spinal cord neurones after cord transection. NeuroReport, 7(5), 1041-1044.
http://dx.doi.org/10.1097/00001756-199604100-00017
---------- CHICAGO ----------
Gonzalez, S., Grillo, C., Gonzalez Deniselle, M.C., Lima, A., McEwen, B.S., De Nicola, A.F. "Dexamethasone up-regulates mRNA for Na+,K+-ATPase in some spinal cord neurones after cord transection" . NeuroReport 7, no. 5 (1996) : 1041-1044.
http://dx.doi.org/10.1097/00001756-199604100-00017
---------- MLA ----------
Gonzalez, S., Grillo, C., Gonzalez Deniselle, M.C., Lima, A., McEwen, B.S., De Nicola, A.F. "Dexamethasone up-regulates mRNA for Na+,K+-ATPase in some spinal cord neurones after cord transection" . NeuroReport, vol. 7, no. 5, 1996, pp. 1041-1044.
http://dx.doi.org/10.1097/00001756-199604100-00017
---------- VANCOUVER ----------
Gonzalez, S., Grillo, C., Gonzalez Deniselle, M.C., Lima, A., McEwen, B.S., De Nicola, A.F. Dexamethasone up-regulates mRNA for Na+,K+-ATPase in some spinal cord neurones after cord transection. NEUROREPORT. 1996;7(5):1041-1044.
http://dx.doi.org/10.1097/00001756-199604100-00017