Abstract:
Circling training (CT) decreases muscarinic acetylcholine receptor (mAchR) binding in rat striatum. As cholinergic and dopaminergic systems interact strongly we evaluated the expression of D2-subtype dopamine receptor (DA D2) and mAchR together after CT. Animals trained from 30 to 37 days of age and sacrificed 2 months later showed an enduring drop in B(max) of 40% in DA D2 and 34% in mAchR. plotting the percentage of binding drop of both receptors for each animal showed that the reduction of one system correlates with the other (r2 = 0.71, p < 0.01; n = 8). Neither mAchR nor DA D2 were affected when training started at 20 or 60 days. We conclude that the presence of a period where CT exerts long term alterations during development involves both cholinergic and dopaminergic systems.
Registro:
Documento: |
Artículo
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Título: | Co-alteration of dopamine D2 receptor and muscarinic acetylcholine receptor binding in rat striatum after circling training |
Autor: | Ibarra, G.R.; Paratcha, G.Ch.; Wolansky, M.J.; Azcurra, J.M. |
Filiación: | Laboratorio de Biologia Celular, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
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Palabras clave: | Circling training; Dopamine D2 receptor; Muscarinic acetylcholine receptor; Rat striatum; Receptor alteration; dopamine 2 receptor; muscarinic receptor; animal experiment; animal tissue; article; circling behavior; controlled study; corpus striatum; locomotion; male; nerve cell plasticity; nonhuman; priority journal; rat; receptor binding |
Año: | 1996
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Volumen: | 7
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Número: | 15-17
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Página de inicio: | 2491
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Página de fin: | 2494
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DOI: |
http://dx.doi.org/10.1097/00001756-199611040-00018 |
Título revista: | NeuroReport
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Título revista abreviado: | NEUROREPORT
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ISSN: | 09594965
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CODEN: | NERPE
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09594965_v7_n15-17_p2491_Ibarra |
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Citas:
---------- APA ----------
Ibarra, G.R., Paratcha, G.Ch., Wolansky, M.J. & Azcurra, J.M.
(1996)
. Co-alteration of dopamine D2 receptor and muscarinic acetylcholine receptor binding in rat striatum after circling training. NeuroReport, 7(15-17), 2491-2494.
http://dx.doi.org/10.1097/00001756-199611040-00018---------- CHICAGO ----------
Ibarra, G.R., Paratcha, G.Ch., Wolansky, M.J., Azcurra, J.M.
"Co-alteration of dopamine D2 receptor and muscarinic acetylcholine receptor binding in rat striatum after circling training"
. NeuroReport 7, no. 15-17
(1996) : 2491-2494.
http://dx.doi.org/10.1097/00001756-199611040-00018---------- MLA ----------
Ibarra, G.R., Paratcha, G.Ch., Wolansky, M.J., Azcurra, J.M.
"Co-alteration of dopamine D2 receptor and muscarinic acetylcholine receptor binding in rat striatum after circling training"
. NeuroReport, vol. 7, no. 15-17, 1996, pp. 2491-2494.
http://dx.doi.org/10.1097/00001756-199611040-00018---------- VANCOUVER ----------
Ibarra, G.R., Paratcha, G.Ch., Wolansky, M.J., Azcurra, J.M. Co-alteration of dopamine D2 receptor and muscarinic acetylcholine receptor binding in rat striatum after circling training. NEUROREPORT. 1996;7(15-17):2491-2494.
http://dx.doi.org/10.1097/00001756-199611040-00018