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Abstract:

Circling training (CT) decreases muscarinic acetylcholine receptor (mAchR) binding in rat striatum. As cholinergic and dopaminergic systems interact strongly we evaluated the expression of D2-subtype dopamine receptor (DA D2) and mAchR together after CT. Animals trained from 30 to 37 days of age and sacrificed 2 months later showed an enduring drop in B(max) of 40% in DA D2 and 34% in mAchR. plotting the percentage of binding drop of both receptors for each animal showed that the reduction of one system correlates with the other (r2 = 0.71, p < 0.01; n = 8). Neither mAchR nor DA D2 were affected when training started at 20 or 60 days. We conclude that the presence of a period where CT exerts long term alterations during development involves both cholinergic and dopaminergic systems.

Registro:

Documento: Artículo
Título:Co-alteration of dopamine D2 receptor and muscarinic acetylcholine receptor binding in rat striatum after circling training
Autor:Ibarra, G.R.; Paratcha, G.Ch.; Wolansky, M.J.; Azcurra, J.M.
Filiación:Laboratorio de Biologia Celular, Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 1428 Buenos Aires, Argentina
Palabras clave:Circling training; Dopamine D2 receptor; Muscarinic acetylcholine receptor; Rat striatum; Receptor alteration; dopamine 2 receptor; muscarinic receptor; animal experiment; animal tissue; article; circling behavior; controlled study; corpus striatum; locomotion; male; nerve cell plasticity; nonhuman; priority journal; rat; receptor binding
Año:1996
Volumen:7
Número:15-17
Página de inicio:2491
Página de fin:2494
DOI: http://dx.doi.org/10.1097/00001756-199611040-00018
Título revista:NeuroReport
Título revista abreviado:NEUROREPORT
ISSN:09594965
CODEN:NERPE
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09594965_v7_n15-17_p2491_Ibarra

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Citas:

---------- APA ----------
Ibarra, G.R., Paratcha, G.Ch., Wolansky, M.J. & Azcurra, J.M. (1996) . Co-alteration of dopamine D2 receptor and muscarinic acetylcholine receptor binding in rat striatum after circling training. NeuroReport, 7(15-17), 2491-2494.
http://dx.doi.org/10.1097/00001756-199611040-00018
---------- CHICAGO ----------
Ibarra, G.R., Paratcha, G.Ch., Wolansky, M.J., Azcurra, J.M. "Co-alteration of dopamine D2 receptor and muscarinic acetylcholine receptor binding in rat striatum after circling training" . NeuroReport 7, no. 15-17 (1996) : 2491-2494.
http://dx.doi.org/10.1097/00001756-199611040-00018
---------- MLA ----------
Ibarra, G.R., Paratcha, G.Ch., Wolansky, M.J., Azcurra, J.M. "Co-alteration of dopamine D2 receptor and muscarinic acetylcholine receptor binding in rat striatum after circling training" . NeuroReport, vol. 7, no. 15-17, 1996, pp. 2491-2494.
http://dx.doi.org/10.1097/00001756-199611040-00018
---------- VANCOUVER ----------
Ibarra, G.R., Paratcha, G.Ch., Wolansky, M.J., Azcurra, J.M. Co-alteration of dopamine D2 receptor and muscarinic acetylcholine receptor binding in rat striatum after circling training. NEUROREPORT. 1996;7(15-17):2491-2494.
http://dx.doi.org/10.1097/00001756-199611040-00018