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Abstract:

The effect of the classical neuroleptic, fluphenazine, on dopamine D1-receptor binding was examined in different regions of the basal ganglia. Whereas exposure to fluphenazine for 18 months reduced [125I]SCH-23982 binding to D1-receptors in the caudate putamen, nucleus accumbens and olfactory tubercle, binding in the entopeduncular nucleus was enhanced after fluphenazine treatment. Competition studies indicated that the region-dependent changes in [125I]SCH-23982 binding after fluphenazine exposure were not due to differences in the affinity of fluphenazine or other dopamine ligands for D1-binding sites. These data suggest that in addition to modulating striatal function, classical neuroleptics may also alter neurotransmission in the basal ganglia by enhancing dopamine receptor binding in the entopeduncular nucleus. © Rapid Communications of Oxford Ltd.

Registro:

Documento: Artículo
Título:Neuroleptics differentially modulate central dopamine d1-receptor binding
Autor:Johnson, A.E.; Coirini, H.; Källström, L.; Gunne, L.M.; Wiesel, F.A.
Filiación:Instituto de Biología y Medicina Experimental, Buenos Aires, 1428, Argentina
Department of Psychiatry, University Hospital, Uppsala University, Uppsala, S-750 17, Sweden
Palabras clave:Basal ganglia; D1-receptors; Dopamine; Entopeduncular nucleus; Entopeduncular nucleus; Extrapyramidal motor system; Fluphenazine; Neuroleptic; Striatum; [125I]SCH-23982; 2 dipropylamino 7 hydroxytetralin; 2,3,4,5 tetrahydro 7,8 dihydroxy 1 phenyl 1h 3 benzazepine; 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol; 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate; clozapine; dopamine; dopamine 1 receptor; fluphenazine; neuroleptic agent; raclopride; animal experiment; animal tissue; article; brain region; controlled study; corpus striatum; entopeduncular nucleus; female; intramuscular drug administration; nonhuman; priority journal; rat; receptor binding; substantia nigra; Animal; Antipsychotic Agents; Autoradiography; Basal Ganglia; Binding, Competitive; Dopamine Antagonists; Female; Iodine Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Sch-23390
Año:1995
Volumen:6
Número:6
Página de inicio:933
Página de fin:936
DOI: http://dx.doi.org/10.1097/00001756-199504190-00027
Título revista:NeuroReport
Título revista abreviado:NeuroReport
ISSN:09594965
CAS:2 dipropylamino 7 hydroxytetralin, 74938-11-7; 2,3,4,5 tetrahydro 7,8 dihydroxy 1 phenyl 1h 3 benzazepine, 67287-49-4; 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol, 116780-39-3; 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate, 87134-87-0; clozapine, 5786-21-0; dopamine, 51-61-6, 62-31-7; fluphenazine, 146-56-5, 69-23-8; raclopride, 84225-95-6; Antipsychotic Agents; Dopamine Antagonists; Iodine Radioisotopes; Receptors, Dopamine D1; Sch 23982, 116780-39-3; Sch-23390, 87075-17-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09594965_v6_n6_p933_Johnson

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Citas:

---------- APA ----------
Johnson, A.E., Coirini, H., Källström, L., Gunne, L.M. & Wiesel, F.A. (1995) . Neuroleptics differentially modulate central dopamine d1-receptor binding. NeuroReport, 6(6), 933-936.
http://dx.doi.org/10.1097/00001756-199504190-00027
---------- CHICAGO ----------
Johnson, A.E., Coirini, H., Källström, L., Gunne, L.M., Wiesel, F.A. "Neuroleptics differentially modulate central dopamine d1-receptor binding" . NeuroReport 6, no. 6 (1995) : 933-936.
http://dx.doi.org/10.1097/00001756-199504190-00027
---------- MLA ----------
Johnson, A.E., Coirini, H., Källström, L., Gunne, L.M., Wiesel, F.A. "Neuroleptics differentially modulate central dopamine d1-receptor binding" . NeuroReport, vol. 6, no. 6, 1995, pp. 933-936.
http://dx.doi.org/10.1097/00001756-199504190-00027
---------- VANCOUVER ----------
Johnson, A.E., Coirini, H., Källström, L., Gunne, L.M., Wiesel, F.A. Neuroleptics differentially modulate central dopamine d1-receptor binding. NeuroReport. 1995;6(6):933-936.
http://dx.doi.org/10.1097/00001756-199504190-00027