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Abstract:

Carbon monoxide (CO), produced through the action of haem oxygenase (HO) isoenzymes, has been recently postulated as a retrograde messenger in the early stages of long-term potentiation (LTP). In the present study, rats submitted to an inhibitory avoidance task there is a significant increase (76%) in hippocampal HO activity immediately after training (0 min), but not at 60 min posttraining. No changes were observed in cerebral cortical and cerebellar HO activity. Bilateral intrahippocampal infusion of the HO inhibitor zinc-protoporphyrin-IX (ZnPP) (2 µg side-1) caused full amnesia for inhibitory avoidance when given 10 min before training or immediately after training, but not 60 min after training. These findings provide evidence that CO production in the hippocampus is important for the early stages of memory processing of an inhibitory avoidance training. © Rapid Communications of Oxford Ltd.

Registro:

Documento: Artículo
Título:Evidence for the involvement of hippocampal CO production in the acquisition and consolidation of inhibitory avoidance learning
Autor:Bernabeu, R.; Princ, F.; De Stein, M.L.; Fin, C.; Ana Juknat, A.; Batile, A.; Ivan, I.; Medina, J.H.
Filiación:Instituto de Biologia Celular, Facultad de Medicina, Brazil
CIPYP, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Centro de Memoria, Instituto de Biociencias, UFRGS, Porto Alegre, Brazil
Palabras clave:Amnesia; CO; Haem oxygenase; Hippocampus; Inhibitory avoidance; Zn-pro-toporphyrin-ix; carbon monoxide; oxygenase; protoporphyrin zinc; animal experiment; animal tissue; article; avoidance behavior; brain cortex; cerebellum; controlled study; hippocampus; learning; male; memory; nonhuman; priority journal; rat; Animal; Avoidance Learning; Carbon Monoxide; Heme Oxygenase (Decyclizing); Hippocampus; Long-Term Potentiation; Male; Rats; Rats, Wistar; Support, Non-U.S. Gov't; Time Factors; Zinc
Año:1995
Volumen:6
Número:3
Página de inicio:516
Página de fin:518
DOI: http://dx.doi.org/10.1097/00001756-199502000-00027
Título revista:NeuroReport
Título revista abreviado:NeuroReport
ISSN:09594965
CAS:carbon monoxide, 630-08-0; oxygenase, 9037-29-0, 9046-59-7; protoporphyrin zinc, 15442-64-5; Carbon Monoxide, 630-08-0; Heme Oxygenase (Decyclizing), EC 1.14.99.3; Zinc, 7440-66-6
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09594965_v6_n3_p516_Bernabeu

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Citas:

---------- APA ----------
Bernabeu, R., Princ, F., De Stein, M.L., Fin, C., Ana Juknat, A., Batile, A., Ivan, I.,..., Medina, J.H. (1995) . Evidence for the involvement of hippocampal CO production in the acquisition and consolidation of inhibitory avoidance learning. NeuroReport, 6(3), 516-518.
http://dx.doi.org/10.1097/00001756-199502000-00027
---------- CHICAGO ----------
Bernabeu, R., Princ, F., De Stein, M.L., Fin, C., Ana Juknat, A., Batile, A., et al. "Evidence for the involvement of hippocampal CO production in the acquisition and consolidation of inhibitory avoidance learning" . NeuroReport 6, no. 3 (1995) : 516-518.
http://dx.doi.org/10.1097/00001756-199502000-00027
---------- MLA ----------
Bernabeu, R., Princ, F., De Stein, M.L., Fin, C., Ana Juknat, A., Batile, A., et al. "Evidence for the involvement of hippocampal CO production in the acquisition and consolidation of inhibitory avoidance learning" . NeuroReport, vol. 6, no. 3, 1995, pp. 516-518.
http://dx.doi.org/10.1097/00001756-199502000-00027
---------- VANCOUVER ----------
Bernabeu, R., Princ, F., De Stein, M.L., Fin, C., Ana Juknat, A., Batile, A., et al. Evidence for the involvement of hippocampal CO production in the acquisition and consolidation of inhibitory avoidance learning. NeuroReport. 1995;6(3):516-518.
http://dx.doi.org/10.1097/00001756-199502000-00027