Abstract:
Experiments were undertaken to determine the distribution and binding profile of dopamine (DA) receptors within a key extra-striatal region of the rat basal ganglia, the subthalamic nucleus (STh). Analysis of [l25I]NCQ-298 autoradiograms showed that binding sites of the D2-receptor family are abundant in the STh. Competition studies indicated that these sites were specifically of the D2 sub-type. However, contrary to previously published data, [l25I]SCH-23982 autoradiograms failed to reveal D1 receptor binding in the STh. These data suggest that DA acting at D2 receptors may directly modulate STh neural activity and furthermore that the antagonism of STh D2 receptor binding by neuroleptics may be involved in the expression of extrapyramidal motor disturbances. © Rapid Communications of Oxford Ltd.
Registro:
Documento: |
Artículo
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Título: | Characterization of dopamine receptor binding sites in the subthalamic nucleus |
Autor: | Johnson, A.E.; Coirini, H.; Källström, L.; Wiesel, F.-A. |
Filiación: | Psychiatry Department, University Hospital, Uppsala University, Uppsala, 75017, Sweden Instituto de Biologia y Medicina Experimental, Buenos Aires, 1428, Argentina
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Palabras clave: | Basal ganglia; D1 receptors; D2 receptors; Dopamine; Entopeduncular nucleus; Extrapyramidal motor system; Neuroleptics; Subthalamic nucleus; [125I]SCH-23982; [l25I]NCQ-298; 2 dipropylamino 7 hydroxytetralin; 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol; 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate; clozapine; dopamine; dopamine 1 receptor; dopamine 2 receptor; eticlopride; fluphenazine; n [(1 ethyl 2 pyrrolidinyl)methyl] 3 iodo 5,6 dimethoxysalicylamide; neuroleptic agent; raclopride; animal tissue; article; autoradiography; controlled study; female; nonhuman; priority journal; rat; receptor binding; subthalamic nucleus; Animal; Autoradiography; Dopamine Agonists; Dopamine Antagonists; Female; Iodine Radioisotopes; Ligands; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides; Sch-23390; Support, Non-U.S. Gov't; Thalamic Nuclei |
Año: | 1994
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Volumen: | 5
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Número: | 14
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Página de inicio: | 1836
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Página de fin: | 1838
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DOI: |
http://dx.doi.org/10.1097/00001756-199409080-00038 |
Título revista: | NeuroReport
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Título revista abreviado: | NeuroReport
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ISSN: | 09594965
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CAS: | 2 dipropylamino 7 hydroxytetralin, 74938-11-7; 2,3,4,5 tetrahydro 8 iodo 3 methyl 5 phenyl 1h 3 benzazepin 7 ol, 116780-39-3; 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate, 87134-87-0; clozapine, 5786-21-0; dopamine, 51-61-6, 62-31-7; eticlopride, 84226-12-0, 97612-24-3; fluphenazine, 146-56-5, 69-23-8; n [(1 ethyl 2 pyrrolidinyl)methyl] 3 iodo 5,6 dimethoxysalicylamide, 131062-31-2; raclopride, 84225-95-6; Dopamine Agonists; Dopamine Antagonists; Iodine Radioisotopes; Ligands; NCQ 298, 131062-31-2; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Dopamine; Salicylamides; Sch 23982, 116780-39-3; Sch-23390, 87075-17-0
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09594965_v5_n14_p1836_Johnson |
Referencias:
- Wiesel, F.-A., Traskman-Bendz, L., (1988) Curr Topics Neuroendocrinol, 8, pp. 117-139
- Farde, L., Wiesel, F.-A., Haldin, C., (1988) Arch Gen Psychiatry, 45, pp. 71-76
- Farde, L., Nordstrom, A.-L., Wiesel, F.-A., (1992) Arch Gen Psychiatry, 49, pp. 538-544
- Tamminga, C.A., Gerlach, J., (1987) New Neuroleptics and Experimental Antipsychotics in Schizophrenia, pp. 1129-1140. , Meltzer Y, ed
- Greenamyre, J.T., (1993) J Neural Transm, 91, pp. 255-269. , Gen Sect
- Kitai, S.T., Kita, H., Anatomy and physiology of the subthalamic nucleus: A driving force of the basal ganglia (1987) Anatomy and Physiology of the Subthal Amic Nucleus: A Driving Force of the Basal Ganglia, pp. 357-373. , Carpenter AB and Jaramen A, eds., New York: Plenum
- Johnson, A.E., Liminga, U., Lidèn, A., Neuroscience, , press
- Versteeg, D.H.G., Van Der Gugten, J., Dejong, W., (1976) Brain Res, 113, pp. 563-574
- Brown, L.L., Makman, M.H., Wolfson, L.I., (1979) Science, 206, pp. 1416-1418
- Björklund, A., Lindvall, O., Dopamine containing systems in the CNS (1984) Dopamine-Containing Systems in the CNS, pp. 55-122. , Björklund A and Hok felt T, eds., Amsterdam: Elsevier
- Mintz, I., Hammond, C., Fegér, J., (1986) Brain Res, 375, pp. 172-175
- Savasta, M., Dubois, A., Scatton, B., (1986) Brain Res, 375, pp. 291-301
- Dawson, T.M., Barone, P., Sidhu, A., (1988) Neuroscience, 26, pp. 83-100
- Mansour, A., Meador-Woodruff, J.H., Zhou, Q., (1992) Neuroscience, 46, pp. 959-971
- Besson, M.-J., Graybiel, A.M., Nastuck, M.A., (1988) Neuroscience, 26, pp. 101-119
- Altar, C.A., Marien, M.R., (1987) J Neurosci, 7, pp. 213-222
- Alburges, M.E., Hunt, M.E., McQuade, R.D., (1992) J Chem Neuroanat, 5, pp. 357-366
- Bouthenet, M.-L., Martres, M.-P., Sales, N., (1987) Neuroscience, 20, pp. 117-155
- Charuchinda, C., Supavilai, P., Karobath, M., (1987) J Neurosci, 7, pp. 1352-1360
- Kessler, R.M., Whetsell, W.O., Sib Ansari, M., (1993) Brain Res, 1993, pp. 237-243
- Brotchie, J.M., Mitchell, I.J., Sambrook, M.A., (1991) Movement Disorders, 6, pp. 133-138
- Guridi, J., Luquin, M.R., Herrero, M.T., (1993) Movement Disorders, 8, pp. 421-429
- Hall, H., Högberg, T., Halldin, C., (1991) Psychopharmacology, 103, pp. 6-18
- Paxinos, G., Watson, C., (1986) The Rat Brain in Stereotaxic Coordinates, , New York: Academic Press
- Lévesque, D., Diaz, J., Pilon, C., (1992) Proc Natl Acad Sci USA, 89, pp. 8155-8159
Citas:
---------- APA ----------
Johnson, A.E., Coirini, H., Källström, L. & Wiesel, F.-A.
(1994)
. Characterization of dopamine receptor binding sites in the subthalamic nucleus. NeuroReport, 5(14), 1836-1838.
http://dx.doi.org/10.1097/00001756-199409080-00038---------- CHICAGO ----------
Johnson, A.E., Coirini, H., Källström, L., Wiesel, F.-A.
"Characterization of dopamine receptor binding sites in the subthalamic nucleus"
. NeuroReport 5, no. 14
(1994) : 1836-1838.
http://dx.doi.org/10.1097/00001756-199409080-00038---------- MLA ----------
Johnson, A.E., Coirini, H., Källström, L., Wiesel, F.-A.
"Characterization of dopamine receptor binding sites in the subthalamic nucleus"
. NeuroReport, vol. 5, no. 14, 1994, pp. 1836-1838.
http://dx.doi.org/10.1097/00001756-199409080-00038---------- VANCOUVER ----------
Johnson, A.E., Coirini, H., Källström, L., Wiesel, F.-A. Characterization of dopamine receptor binding sites in the subthalamic nucleus. NeuroReport. 1994;5(14):1836-1838.
http://dx.doi.org/10.1097/00001756-199409080-00038