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Abstract:

Our research objective was to characterize the biochemical effect of streptomycin during postnatal rat cerebral cortex development using a sensitive method that preserves the in situ topological relationship. We found a decrease in the mannosylation of asparagine-linked oligosaccharides without affecting polypeptide synthesis, DNA synthesis or glucose and mannose disappearance from the medium in mini-tissue units derived from P5. In addition, the rate of Dolp-GlcNAc2Man9Glc3 synthesis and the oligosaccharide protein transferase activity did not change in the presence of the aminoglycoside. These findings strongly suggested that the alteration of protein mannosylation occurred downstream of G3 transfer to nascent polypeptides. Further, the mini-tissue units may be useful for the assessment of neurological toxicity of antibacterial agents. (C) 2000 Lippincott Williams and Wilkins.

Registro:

Documento: Artículo
Título:Altered protein mannosylation in developing cerebral cortex by streptomycin
Autor:Alperin, M.D.; Calandria, J.M.; Carminatti, H.; Idoyaga-Vargas, V.P.
Filiación:Instituto de Investigaciones, Bioquimicas Fundacion Campomar, FCEyN UBA, Avda Patricias Argentinas 435, Capital Federal CP1405, Buenos Aires, Argentina
Palabras clave:Cerebral cortex; Mini-tissue units; Neurotoxicity; Protein glycosylation; Streptomycin; aminoglycoside antibiotic agent; antibiotic agent; asparagine linked oligosaccharide; carbon 14; DNA; glucose; mannose; streptomycin; tritium; animal tissue; article; brain cortex; brain development; concentration response; controlled study; DNA synthesis; nervous system development; neurotoxicity; newborn; nonhuman; priority journal; protein glycosylation; protein synthesis; rat
Año:2000
Volumen:11
Número:16
Página de inicio:3569
Página de fin:3572
DOI: http://dx.doi.org/10.1097/00001756-200011090-00033
Título revista:NeuroReport
Título revista abreviado:NeuroReport
ISSN:09594965
CODEN:NERPE
CAS:carbon 14, 14762-75-5; DNA, 9007-49-2; glucose, 50-99-7, 84778-64-3; mannose, 31103-86-3, 3458-28-4; streptomycin, 57-92-1; tritium, 10028-17-8
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09594965_v11_n16_p3569_Alperin

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Citas:

---------- APA ----------
Alperin, M.D., Calandria, J.M., Carminatti, H. & Idoyaga-Vargas, V.P. (2000) . Altered protein mannosylation in developing cerebral cortex by streptomycin. NeuroReport, 11(16), 3569-3572.
http://dx.doi.org/10.1097/00001756-200011090-00033
---------- CHICAGO ----------
Alperin, M.D., Calandria, J.M., Carminatti, H., Idoyaga-Vargas, V.P. "Altered protein mannosylation in developing cerebral cortex by streptomycin" . NeuroReport 11, no. 16 (2000) : 3569-3572.
http://dx.doi.org/10.1097/00001756-200011090-00033
---------- MLA ----------
Alperin, M.D., Calandria, J.M., Carminatti, H., Idoyaga-Vargas, V.P. "Altered protein mannosylation in developing cerebral cortex by streptomycin" . NeuroReport, vol. 11, no. 16, 2000, pp. 3569-3572.
http://dx.doi.org/10.1097/00001756-200011090-00033
---------- VANCOUVER ----------
Alperin, M.D., Calandria, J.M., Carminatti, H., Idoyaga-Vargas, V.P. Altered protein mannosylation in developing cerebral cortex by streptomycin. NeuroReport. 2000;11(16):3569-3572.
http://dx.doi.org/10.1097/00001756-200011090-00033