Abstract:
IN previous studies we found that there is a critical period during rat postnatal development when motor training starting at age 30 days (P30) but not before or after this age, induces a bilateral lifetime drop in B(max) of the muscarinic radioligand [3H]QNB in striatum. We examined the possibility that striatal NGF level would be a determining factor for the normal occurrence of this synaptic plasticity. With this aim, rats underwent training at P30-37 with or without simultaneous NGF perfusion into the left striatum. At P70, we found the expected bilateral enduring fall of striatal [3H]QNB sites in trained controls. While the non-cannulated side of NGF- treated trained rats showed a similar drop in [3H]QNB binding, the perfused striata from these animals were not affected by training. Thus, the findings add new evidence in favour of a major role of NGF in this critical period of activity-dependent permanent adjustment in the striatal muscarinic system.
Registro:
Documento: |
Artículo
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Título: | Exogenous NGF alters a critical motor period in rat striatum |
Autor: | Wolansky, M.J.; Cabrera, R.J.; Ibarra, G.R.; Monglat, L.; Azcurra, J.M. |
Filiación: | Departamento de Biología, Pabellón II, Universidad de Buenos Aires, Piso 4, CP1428, Buenos Aires, Argentina
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Palabras clave: | Circling; Development; mAchR; NGF; Plasticity; Rat Striatum; Training; nerve growth factor; animal experiment; animal model; article; brain maturation; circling behavior; controlled study; corpus striatum; ligand binding; motor performance; nerve cell plasticity; neurotransmission; neurotransmitter release; nonhuman; postnatal development; priority journal; rat; synaptic transmission; synaptogenesis; training |
Año: | 1999
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Volumen: | 10
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Número: | 13
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Página de inicio: | 2705
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Página de fin: | 2709
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DOI: |
http://dx.doi.org/10.1097/00001756-199909090-00003 |
Título revista: | NeuroReport
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Título revista abreviado: | NeuroReport
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ISSN: | 09594965
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CODEN: | NERPE
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CAS: | nerve growth factor, 9061-61-4
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09594965_v10_n13_p2705_Wolansky |
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Citas:
---------- APA ----------
Wolansky, M.J., Cabrera, R.J., Ibarra, G.R., Monglat, L. & Azcurra, J.M.
(1999)
. Exogenous NGF alters a critical motor period in rat striatum. NeuroReport, 10(13), 2705-2709.
http://dx.doi.org/10.1097/00001756-199909090-00003---------- CHICAGO ----------
Wolansky, M.J., Cabrera, R.J., Ibarra, G.R., Monglat, L., Azcurra, J.M.
"Exogenous NGF alters a critical motor period in rat striatum"
. NeuroReport 10, no. 13
(1999) : 2705-2709.
http://dx.doi.org/10.1097/00001756-199909090-00003---------- MLA ----------
Wolansky, M.J., Cabrera, R.J., Ibarra, G.R., Monglat, L., Azcurra, J.M.
"Exogenous NGF alters a critical motor period in rat striatum"
. NeuroReport, vol. 10, no. 13, 1999, pp. 2705-2709.
http://dx.doi.org/10.1097/00001756-199909090-00003---------- VANCOUVER ----------
Wolansky, M.J., Cabrera, R.J., Ibarra, G.R., Monglat, L., Azcurra, J.M. Exogenous NGF alters a critical motor period in rat striatum. NeuroReport. 1999;10(13):2705-2709.
http://dx.doi.org/10.1097/00001756-199909090-00003