Abstract:
Programmed remodeling of cell surface glycans by the sequential action of specific glycosyltransferases can control biological processes by generating or masking ligands for endogenous lectins. Galectins, a family of animal lectins with affinity for β-galactosides, can form multivalent complexes with cell surface glycoconjugates and deliver a variety of intracellular signals to modulate cell activation, differentiation, and survival. Recent efforts involving genetic or biochemical manipulation of O-glycosylation and N-glycosylation pathways, as well as blockade of the synthesis of endogenous galectins, have illuminated essential roles for galectin-glycoprotein lattices in the control of biological processes including receptor turnover and endocytosis, host-pathogen interactions, and immune cell activation and homeostasis. © 2007 Elsevier Ltd. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Functions of cell surface galectin-glycoprotein lattices |
Autor: | Rabinovich, G.A.; Toscano, M.A.; Jackson, S.S.; Vasta, G.R. |
Filiación: | Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, CONICET, Vuelta de Obligado 2490, C1428ADN Buenos Aires, Argentina Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428ADN Buenos Aires, Argentina Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, United States
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Palabras clave: | B lymphocyte receptor; beta galactoside; galectin; glycoconjugate; glycoprotein; T lymphocyte receptor; binding affinity; cell activation; cell death; cell differentiation; cell surface; cell survival; complex formation; endocytosis; glycosylation; helper cell; homeostasis; host pathogen interaction; immunocompetent cell; nonhuman; oyster; priority journal; protein carbohydrate interaction; protein function; protein protein interaction; protein structure; protein synthesis; regulatory mechanism; review; signal transduction; tandem repeat; Animals; B-Lymphocytes; Cell Membrane; Galectins; Host-Pathogen Interactions; Humans; Immunity, Natural; Membrane Glycoproteins; Models, Molecular; Multiprotein Complexes; T-Lymphocytes; Animalia |
Año: | 2007
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Volumen: | 17
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Número: | 5
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Página de inicio: | 513
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Página de fin: | 520
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DOI: |
http://dx.doi.org/10.1016/j.sbi.2007.09.002 |
Título revista: | Current Opinion in Structural Biology
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Título revista abreviado: | Curr. Opin. Struct. Biol.
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ISSN: | 0959440X
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CODEN: | COSBE
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CAS: | Galectins; Membrane Glycoproteins; Multiprotein Complexes
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0959440X_v17_n5_p513_Rabinovich |
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Citas:
---------- APA ----------
Rabinovich, G.A., Toscano, M.A., Jackson, S.S. & Vasta, G.R.
(2007)
. Functions of cell surface galectin-glycoprotein lattices. Current Opinion in Structural Biology, 17(5), 513-520.
http://dx.doi.org/10.1016/j.sbi.2007.09.002---------- CHICAGO ----------
Rabinovich, G.A., Toscano, M.A., Jackson, S.S., Vasta, G.R.
"Functions of cell surface galectin-glycoprotein lattices"
. Current Opinion in Structural Biology 17, no. 5
(2007) : 513-520.
http://dx.doi.org/10.1016/j.sbi.2007.09.002---------- MLA ----------
Rabinovich, G.A., Toscano, M.A., Jackson, S.S., Vasta, G.R.
"Functions of cell surface galectin-glycoprotein lattices"
. Current Opinion in Structural Biology, vol. 17, no. 5, 2007, pp. 513-520.
http://dx.doi.org/10.1016/j.sbi.2007.09.002---------- VANCOUVER ----------
Rabinovich, G.A., Toscano, M.A., Jackson, S.S., Vasta, G.R. Functions of cell surface galectin-glycoprotein lattices. Curr. Opin. Struct. Biol. 2007;17(5):513-520.
http://dx.doi.org/10.1016/j.sbi.2007.09.002