Artículo
Abstract:
We studied the natural inhibitors (NI) of blood coagulation and fibrinolysis in 50 patients with lupus anticoagulant (LA), in order to identify possible alterations of these NI, that could favour thrombotic manifestations. We found no statistically significant difference in antithrombin III, protein C and α2-antiplasmin between controls and patients with LA, irrespective of their clinical manifestations. We found an increase of plasminogen activator inhibitor (PAI, P < 0.001) and a decrease of free protein S (PS(f), P < 0.001) and total protein S (PS(t), 0.01 < P < 0.05) in the patients with LA when compared with the control group. We found no difference in the levels of NI between patients with thrombosis (n = 19) and without thrombosis (n = 31) nor between patients with (n = 25) or without thrombosis and/or foetal loss (n = 25). In contrast, we observed a decrease of PS(f) in women with foetal loss (n = 10) as compared with women without foetal loss (n = 22, 0.01 < P < 0.05) and a decrease of PS(f) when comparing 19 patients with systemic lupus erythematosus (SLE) with 31 patients without SLE (0.01 < P < 0.05). These findings show that the patients with LA had several abnormalities in the NI system, but there was no significant association between levels of PAI, PS(f), PS(t) and a history of thrombosis.
Registro:
| Documento: | Artículo |
| Título: | Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant |
| Autor: | Kordich, L.C.; Forastiero, R.R.; Basilotta, E.; Porterie, P.; Carreras, L.O. |
| Filiación: | Departamento de Quimica Biologica, Fac. de Ciencias Exactas/Naturales, Universidad de Buenos Aires, 40 Piso Pabellon II, 1428 Buenos Aires, Argentina |
| Palabras clave: | antithrombin iii; blood clotting inhibitor; lupus anticoagulant; plasminogen activator inhibitor; protein c; protein s; adolescent; adult; article; child; controlled study; female; human; major clinical study; male; systemic lupus erythematosus; thrombosis; Abortion, Habitual; Adolescent; Adult; Antiplasmin; Antithrombin III; Autoimmune Diseases; Blood Coagulation; Child; Comparative Study; Female; Fibrinolysis; Hematologic Diseases; Human; Infection; Lupus Coagulation Inhibitor; Lupus Erythematosus, Systemic; Male; Middle Age; Neoplasms; Plasminogen Activator Inhibitor 1; Pregnancy; Protein C; Protein S; Thrombosis |
| Año: | 1992 |
| Volumen: | 3 |
| Número: | 6 |
| Página de inicio: | 765 |
| Página de fin: | 771 |
| Título revista: | Blood Coagulation and Fibrinolysis |
| Título revista abreviado: | BLOOD COAGUL. FIBRINOLYSIS |
| ISSN: | 09575235 |
| CODEN: | BLFIE |
| CAS: | antithrombin III, 90170-80-2; plasminogen activator inhibitor, 105844-41-5; protein C, 60202-16-6; Antiplasmin; Antithrombin III, 9000-94-6; Lupus Coagulation Inhibitor; Plasminogen Activator Inhibitor 1; Protein C; Protein S |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09575235_v3_n6_p765_Kordich |
Citas:
---------- APA ----------
Kordich, L.C., Forastiero, R.R., Basilotta, E., Porterie, P. & Carreras, L.O. (1992) . Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant. Blood Coagulation and Fibrinolysis, 3(6), 765-771.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09575235_v3_n6_p765_Kordich [ ]
---------- CHICAGO ----------
Kordich, L.C., Forastiero, R.R., Basilotta, E., Porterie, P., Carreras, L.O. "Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant" . Blood Coagulation and Fibrinolysis 3, no. 6 (1992) : 765-771.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09575235_v3_n6_p765_Kordich [ ]
---------- MLA ----------
Kordich, L.C., Forastiero, R.R., Basilotta, E., Porterie, P., Carreras, L.O. "Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant" . Blood Coagulation and Fibrinolysis, vol. 3, no. 6, 1992, pp. 765-771.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09575235_v3_n6_p765_Kordich [ ]
---------- VANCOUVER ----------
Kordich, L.C., Forastiero, R.R., Basilotta, E., Porterie, P., Carreras, L.O. Natural inhibitors of blood coagulation and fibrinolysis in patients with lupus anticoagulant. BLOOD COAGUL. FIBRINOLYSIS. 1992;3(6):765-771.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09575235_v3_n6_p765_Kordich [ ]
