Artículo
Murúa, A.; Quintana, I.; Galarza, C.; Alfie, J.; Kordich, L. "Unsuspected hyperhomocysteinemia in chronically anticoagulated patients" (2001) Blood Coagulation and Fibrinolysis. 12(1):79-80
Estamos trabajando para incorporar este artículo al repositorio
Consulte la política de Acceso Abierto del editor
Abstract:
Hyperhomocysteinemia is a risk factor for arterial and venous thrombosis. The aim of this study was to evaluate plasmatic homocysteine levels in patients under chronic anticoagulant treatment with dietary restriction of green vegetables. This kind of food is a very important source not only of vitamin K but also of folates, which are involved in Hcy metabolism. It is known that the lower the folate levels, the higher the Hcy concentration, so we suspected that these patients could show hyperhomocysteinemia. A group of patients receiving oral anticoagulant treatment and a restricted diet (Group 1, n =20) was compared with a group of untreated subjects of a similar age that were not on a restricted diet (Group II, n = 35). Group I showed significantly higher levels of plasmatic Hcy and significantly lower levels of serum folate than Group II. Therefore, a diet restricted in vitamin K applied to oral anticoagulated patients could induce an unwanted increase of homocysteine levels. © 2001 Lippincott Williams & Wilkins.
Registro:
| Documento: | Artículo |
| Título: | Unsuspected hyperhomocysteinemia in chronically anticoagulated patients |
| Autor: | Murúa, A.; Quintana, I.; Galarza, C.; Alfie, J.; Kordich, L. |
| Filiación: | Lab. de Hemostasia y Trombosis, Departamento de Quimica Biologica, Facultad de Cie. Exactas y Naturales, Ciudad Universitaria, 1428 Buenos Aires, Argentina |
| Palabras clave: | Anticoagulant treatment; Diet; Hyperhomocysteinemia; anticoagulant agent; folic acid derivative; homocysteine; vitamin K group; adult; anticoagulation; artery thrombosis; article; clinical article; controlled study; diet restriction; human; hyperhomocysteinemia; metabolism; priority journal; risk factor; vegetable; vein thrombosis; Aged; Anticoagulants; Case-Control Studies; Chronic Disease; Diet; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Middle Aged; Vegetables; Vitamin K |
| Año: | 2001 |
| Volumen: | 12 |
| Número: | 1 |
| Página de inicio: | 79 |
| Página de fin: | 80 |
| DOI: | http://dx.doi.org/10.1097/00001721-200101000-00012 |
| Título revista: | Blood Coagulation and Fibrinolysis |
| Título revista abreviado: | Blood Coagul. Fibrinolysis |
| ISSN: | 09575235 |
| CODEN: | BLFIE |
| CAS: | Anticoagulants; Folic Acid, 59-30-3; Homocysteine, 454-28-4; Vitamin K, 12001-79-5 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09575235_v12_n1_p79_Murua |
Referencias:
- Eikelboom, J.W., Loon, E., Genest J., Jr., Hankey, G., Yusuf, S., Homocyst(e)ine and cardiovascular disease: A critical review of the epidemiologic evidence (1999) Ann Intern Med, 131, pp. 363-375
- Ray, J.G., Meta-analysis of hyperhomocysteinemia as a risk factor for venous thromboembolic disease (1998) Arch Intern Med, 158, pp. 2101-2106
- Langman, L.J., Ray, J.G., Evrovski, J., Yeo, E., Cole, D.E., Hyperhomocyst(e)inemia and the increased risk of venous thromboembolism: More evidence from a case-control study (2000) Arch Intern Med, 160, pp. 961-964
- Peterson, J.C., Spence, J.D., Vitamins and progression of atherosclerosis in hyperhomocysteinemia (1998) Lancet, 351, p. 263
- Mallinow, M.R., Nieto, F.J., Kruger, W.D., Duell, P., Hess, D.L., Glukman, R.A., The effects of folic acid supplementation on plasma total homocysteine are modulate by multivitamin use and methylenetetrahydrofolate reductase genotypes (1997) Arterioscler Thromb Vasc Biol, 17, pp. 1157-1162
- Selhub, J., Jacques, P.F., Rosemberg, I.H., Rogers, G., Bowman, B.A., Gunter, E.W., Serum total homocysteine concentrations in the Third National Health and Nutrition Examination Survey (1991-1994): Population reference ranges and contribution of vitamin status to high serum concentration (1999) Ann Intern Med, 131, pp. 331-339
- Jacob, R.A., Wu, M.M., Henning, S.M., Swendseid, M.E., Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction (1994) J. Nutr, 124, pp. 1072-1080
- Lubetsky, A., Vitamin K intake and sensitivity to warfarin patients consuming regular diets (1999) Thromb Haemostas, 81, pp. 396-399
- Boot, S.L., Charnley, J.M., Sadoski, J.A., Saltzman, E., Bowill, E.G., Cushman, M., Dietary vitamin K1 and stability of oral anticoagulation proposal of a diet with constant vitamin K1 content (1997) Thromb Haemostas, 77, pp. 504-509
Citas:
---------- APA ----------
Murúa, A., Quintana, I., Galarza, C., Alfie, J. & Kordich, L. (2001) . Unsuspected hyperhomocysteinemia in chronically anticoagulated patients. Blood Coagulation and Fibrinolysis, 12(1), 79-80.http://dx.doi.org/10.1097/00001721-200101000-00012
---------- CHICAGO ----------
Murúa, A., Quintana, I., Galarza, C., Alfie, J., Kordich, L. "Unsuspected hyperhomocysteinemia in chronically anticoagulated patients" . Blood Coagulation and Fibrinolysis 12, no. 1 (2001) : 79-80.http://dx.doi.org/10.1097/00001721-200101000-00012
---------- MLA ----------
Murúa, A., Quintana, I., Galarza, C., Alfie, J., Kordich, L. "Unsuspected hyperhomocysteinemia in chronically anticoagulated patients" . Blood Coagulation and Fibrinolysis, vol. 12, no. 1, 2001, pp. 79-80.http://dx.doi.org/10.1097/00001721-200101000-00012
---------- VANCOUVER ----------
Murúa, A., Quintana, I., Galarza, C., Alfie, J., Kordich, L. Unsuspected hyperhomocysteinemia in chronically anticoagulated patients. Blood Coagul. Fibrinolysis. 2001;12(1):79-80.http://dx.doi.org/10.1097/00001721-200101000-00012
