Abstract:
An innovative combination strategy that uses pure enzymes and whole microbial cells in the same process was used to prepare enantiomerically pure 3-carboxyalkyl-γ-butyrolactones and several alkyl esters of 2-hydroxyglutarate from 2-oxoglutaric acid. An innovative combination strategy that uses pure enzymes and whole microbial cells in the same process was used to prepare enantiomerically pure 3-carboxyalkyl-γ-butyrolactones and several alkyl esters of 2-hydroxyglutarates from 2-oxoglutaric acid. The method involves two consecutive biocatalytic steps. The first step, which converts the 2-oxoglutaric acid into the corresponding dialkyl esters, was catalyzed by a lipase. Then in the second step, by microbial reduction of the dialkyl-2-oxoglutarates, it is possible to obtain 3-carboxyalkyl-γ- butyrolactones or 2-hydroxyesters depending on the length of the chain in the alkyl moiety of the esters and on the fresh or lyophilized status of the cells. © 2004 Elsevier Ltd. All rights reserved.
Registro:
Documento: |
Artículo
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Título: | Combination strategy using pure enzymes and whole cells as biocatalysts for the preparation of 2-hydroxyesters and lactones from 2-oxoglutaric acid |
Autor: | Rustoy, E.M.; Pereyra, E.N.; Moreno, S.; Baldessari, A. |
Filiación: | Depto. de Quim. Organ. Y UMYMFOR, Fac. de Ciencias Exactas Y Naturales, Univ. Buenos Aires, Pabellon 2, P., Argentina Depto. de Quím. Biol., Fac. de Ciencias Exactas Y Naturales, Univ. Buenos Aires, Pabellon 2, P., Argentina
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Palabras clave: | 2 oxoglutaric acid; ester derivative; fungal enzyme; lactone derivative; triacylglycerol lipase; acidification; alkylation; article; biocatalyst; catalysis; derivatization; drug synthesis; enantiomer; enzyme mechanism; esterification; lactonization; priority journal |
Año: | 2004
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Volumen: | 15
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Número: | 23
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Página de inicio: | 3763
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Página de fin: | 3768
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DOI: |
http://dx.doi.org/10.1016/j.tetasy.2004.10.013 |
Título revista: | Tetrahedron Asymmetry
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Título revista abreviado: | Tetrahedron Asymmetry
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ISSN: | 09574166
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CODEN: | TASYE
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CAS: | 2 oxoglutaric acid, 328-50-7; triacylglycerol lipase, 9001-62-1
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09574166_v15_n23_p3763_Rustoy |
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Citas:
---------- APA ----------
Rustoy, E.M., Pereyra, E.N., Moreno, S. & Baldessari, A.
(2004)
. Combination strategy using pure enzymes and whole cells as biocatalysts for the preparation of 2-hydroxyesters and lactones from 2-oxoglutaric acid. Tetrahedron Asymmetry, 15(23), 3763-3768.
http://dx.doi.org/10.1016/j.tetasy.2004.10.013---------- CHICAGO ----------
Rustoy, E.M., Pereyra, E.N., Moreno, S., Baldessari, A.
"Combination strategy using pure enzymes and whole cells as biocatalysts for the preparation of 2-hydroxyesters and lactones from 2-oxoglutaric acid"
. Tetrahedron Asymmetry 15, no. 23
(2004) : 3763-3768.
http://dx.doi.org/10.1016/j.tetasy.2004.10.013---------- MLA ----------
Rustoy, E.M., Pereyra, E.N., Moreno, S., Baldessari, A.
"Combination strategy using pure enzymes and whole cells as biocatalysts for the preparation of 2-hydroxyesters and lactones from 2-oxoglutaric acid"
. Tetrahedron Asymmetry, vol. 15, no. 23, 2004, pp. 3763-3768.
http://dx.doi.org/10.1016/j.tetasy.2004.10.013---------- VANCOUVER ----------
Rustoy, E.M., Pereyra, E.N., Moreno, S., Baldessari, A. Combination strategy using pure enzymes and whole cells as biocatalysts for the preparation of 2-hydroxyesters and lactones from 2-oxoglutaric acid. Tetrahedron Asymmetry. 2004;15(23):3763-3768.
http://dx.doi.org/10.1016/j.tetasy.2004.10.013