Artículo
Villamil, S.M.; Alche, L.E.; Coto, C.E. "Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin" (1995) Antiviral Chemistry and Chemotherapy. 6(4):239-244
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Abstract:
Meliacine, a peptide isolated from leaves of Melia azedarach L., exhibited potent activity against herpes simplex type 1 (HSV-1). The in vitro selective indices for pre- and post-treatment were 937.5 and 2500, respectively. Analysis of early events following infection showed that meliacine did not affect viral adsorption and penetration. Meliacine strongly inhibited specific infected-cell polypeptides (ICPs) produced late in infection. The antiviral activity, which is attributed mainly to this selective effect, was also demonstrated in an immunofluorescence assay.
Registro:
| Documento: | Artículo |
| Título: | Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin |
| Autor: | Villamil, S.M.; Alche, L.E.; Coto, C.E. |
| Filiación: | Lab. of Virology, Faculty of Science, University of Buenos Aires, Ciudad Univ., Pabellon II, 4to., 1428 Buenos Aires, Argentina |
| Palabras clave: | Antiviral activity; HSV-1; Meliacine; Protein synthesis inhibition; meliacine; plant extract; unclassified drug; antiviral activity; article; controlled study; Herpes simplex virus 1; nonhuman; priority journal; protein synthesis inhibition; virus inhibition; virus replication |
| Año: | 1995 |
| Volumen: | 6 |
| Número: | 4 |
| Página de inicio: | 239 |
| Página de fin: | 244 |
| DOI: | http://dx.doi.org/10.1177/095632029500600406 |
| Título revista: | Antiviral Chemistry and Chemotherapy |
| Título revista abreviado: | ANTIVIRAL CHEM. CHEMOTHER. |
| ISSN: | 09563202 |
| CODEN: | ACCHE |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09563202_v6_n4_p239_Villamil |
Citas:
---------- APA ----------
Villamil, S.M., Alche, L.E. & Coto, C.E. (1995) . Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin. Antiviral Chemistry and Chemotherapy, 6(4), 239-244.http://dx.doi.org/10.1177/095632029500600406
---------- CHICAGO ----------
Villamil, S.M., Alche, L.E., Coto, C.E. "Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin" . Antiviral Chemistry and Chemotherapy 6, no. 4 (1995) : 239-244.http://dx.doi.org/10.1177/095632029500600406
---------- MLA ----------
Villamil, S.M., Alche, L.E., Coto, C.E. "Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin" . Antiviral Chemistry and Chemotherapy, vol. 6, no. 4, 1995, pp. 239-244.http://dx.doi.org/10.1177/095632029500600406
---------- VANCOUVER ----------
Villamil, S.M., Alche, L.E., Coto, C.E. Inhibition of herpes simplex virus type-1 multiplication by meliacine, a peptide of plant origin. ANTIVIRAL CHEM. CHEMOTHER. 1995;6(4):239-244.http://dx.doi.org/10.1177/095632029500600406
