Artículo

Mandal, P.; Mateu, C.G.; Chattopadhyay, K.; Pujol, C.A.; Damonte, E.B.; Ray, B. "Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica" (2007) Antiviral Chemistry and Chemotherapy. 18(3):153-162
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Abstract:

Natural compounds offer interesting pharmacological perspectives for antiviral drug development. In this study, we have analysed sulphated-fucan- containing fractions isolated from the brown seaweed Cystoseira indica. The crude water extract (CiWE) and the main fraction (CiF3) obtained by anion exchange chromatography had potent antiviral activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) without cytotoxicity for Vero cell cultures. Furthermore, they had no direct inactivating effect on virions in a virucidal assay, and lacked anticoagulant activity. The mode of action of these compounds could be mainly ascribed to an inhibitory effect on virus adsorption. Chemical, chromatographic and spectroscopic methods showed that the major polysaccharide had an apparent molecular mass of 35 kDa and contained a backbone of α-(1→3)-linked fucopyranosyl residues substituted at C-2 with fucopyranosyl and xylopyranosyl residues. This sulphated fucan, considered the active principle of the C. indica water extract, also contained variously linked xylose and galactose units and glucuronic acid residues. Sulphate groups, if present, are located mostly at C-4 of (1→3)-Iinked fucopyranosyl units, and appeared to be very important for the anti-herpetic activity of this polymer. ©2007 International Medical Press.

Registro:

Documento: Artículo
Título:Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica
Autor:Mandal, P.; Mateu, C.G.; Chattopadhyay, K.; Pujol, C.A.; Damonte, E.B.; Ray, B.
Filiación:Natural Products Laboratory, Department of Chemistry, University of Burdwan, WB, India
Laboratorio de Virologia, Departamento de Química Biólogica, Ciudad Universitaria-Pabellón 2, Buenos Aires, Argentina
Palabras clave:Antiviral; Brown seaweed; Cystoseira indica; Herpes simplex virus; Sulphated fucan; Cystoseira indica extract; plant extract; unclassified drug; animal cell; anion exchange chromatography; anticoagulation; antiviral activity; article; cell culture; controlled study; cytotoxicity; drug mechanism; drug potency; Herpes simplex virus 1; Herpes simplex virus 2; linkage analysis; molecular weight; nonhuman; nuclear magnetic resonance spectroscopy; priority journal; seaweed; Vero cell
Año:2007
Volumen:18
Número:3
Página de inicio:153
Página de fin:162
DOI: http://dx.doi.org/10.1177/095632020701800305
Título revista:Antiviral Chemistry and Chemotherapy
Título revista abreviado:Antiviral Chem. Chemother.
ISSN:09563202
CODEN:ACCHE
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09563202_v18_n3_p153_Mandal

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Citas:

---------- APA ----------
Mandal, P., Mateu, C.G., Chattopadhyay, K., Pujol, C.A., Damonte, E.B. & Ray, B. (2007) . Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica. Antiviral Chemistry and Chemotherapy, 18(3), 153-162.
http://dx.doi.org/10.1177/095632020701800305
---------- CHICAGO ----------
Mandal, P., Mateu, C.G., Chattopadhyay, K., Pujol, C.A., Damonte, E.B., Ray, B. "Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica" . Antiviral Chemistry and Chemotherapy 18, no. 3 (2007) : 153-162.
http://dx.doi.org/10.1177/095632020701800305
---------- MLA ----------
Mandal, P., Mateu, C.G., Chattopadhyay, K., Pujol, C.A., Damonte, E.B., Ray, B. "Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica" . Antiviral Chemistry and Chemotherapy, vol. 18, no. 3, 2007, pp. 153-162.
http://dx.doi.org/10.1177/095632020701800305
---------- VANCOUVER ----------
Mandal, P., Mateu, C.G., Chattopadhyay, K., Pujol, C.A., Damonte, E.B., Ray, B. Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica. Antiviral Chem. Chemother. 2007;18(3):153-162.
http://dx.doi.org/10.1177/095632020701800305