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Abstract:

Purpose: The aim of this study was to investigate tolerance to UV-C (ultraviolet C, 280-100 nm) radiation in Drosophila melanogaster, implementing a quantitative trait locus (QTL) mapping approach. This is of interest to test for genetic variation in survival to UV (ultraviolet) radiation. Materials and methods: We performed a QTL scan in D. melanogaster recombinant inbred lines (RIL) constructed from parental stocks derived from a crossing between northern and southern hemisphere populations that segregated substantial genetic variation in thermal resistance in a previous study. Here, two experimental treatments were implemented: Continuous and cyclic UV-C radiation. Results: Significant QTL were detected on all three major chromosomes. Among these, multiple trait composite interval mapping revealed a significant QTL in the pericentromeric region of chromosome 2, a genome region consistently implicated in thermotolerance in previous studies. Conclusions: This study shows substantial genetic variation for UV-C radiation resistance in D. melanogaster, with QTL for survival to UV-C radiation generally overlapping with major thermotolerance QTL. The genetic architecture of UV-C radiation resistance appears to be more complex in continuously irradiated individuals. © 2013 Informa UK, Ltd.

Registro:

Documento: Artículo
Título:QTL for survival to UV-C radiation in Drosophila melanogaster
Autor:Gomez, F.H.; Loeschcke, V.; Norry, F.M.
Filiación:Departamento de Ecología Genética y Evolución, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, (C-1428-EHA) Buenos Aires, Argentina
Department of Bioscience, Integrative Ecology and Evolution, Aarhus University, Aarhus C, Denmark
Palabras clave:Environmental stress; Multiple trait mapping; Thermotolerance; Ultraviolet radiation; allele; animal experiment; article; chromosome 2; Drosophila melanogaster; female; gene mapping; genetic variability; genotype; heat tolerance; male; nonhuman; Northern Hemisphere; priority journal; quantitative trait locus; radiation dose; Southern Hemisphere; survival; ultraviolet C radiation; Animals; Dose-Response Relationship, Radiation; Drosophila melanogaster; Quantitative Trait Loci; Radiation Dosage; Radiation Tolerance; Survival Rate; Ultraviolet Rays; Drosophila melanogaster
Año:2013
Volumen:89
Número:7
Página de inicio:583
Página de fin:589
DOI: http://dx.doi.org/10.3109/09553002.2012.711503
Título revista:International Journal of Radiation Biology
Título revista abreviado:Int. J. Radiat. Biol.
ISSN:09553002
CODEN:IJRBA
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09553002_v89_n7_p583_Gomez

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Citas:

---------- APA ----------
Gomez, F.H., Loeschcke, V. & Norry, F.M. (2013) . QTL for survival to UV-C radiation in Drosophila melanogaster. International Journal of Radiation Biology, 89(7), 583-589.
http://dx.doi.org/10.3109/09553002.2012.711503
---------- CHICAGO ----------
Gomez, F.H., Loeschcke, V., Norry, F.M. "QTL for survival to UV-C radiation in Drosophila melanogaster" . International Journal of Radiation Biology 89, no. 7 (2013) : 583-589.
http://dx.doi.org/10.3109/09553002.2012.711503
---------- MLA ----------
Gomez, F.H., Loeschcke, V., Norry, F.M. "QTL for survival to UV-C radiation in Drosophila melanogaster" . International Journal of Radiation Biology, vol. 89, no. 7, 2013, pp. 583-589.
http://dx.doi.org/10.3109/09553002.2012.711503
---------- VANCOUVER ----------
Gomez, F.H., Loeschcke, V., Norry, F.M. QTL for survival to UV-C radiation in Drosophila melanogaster. Int. J. Radiat. Biol. 2013;89(7):583-589.
http://dx.doi.org/10.3109/09553002.2012.711503