Artículo

Bazzano, M.V.; Sarrible, G.B.; Martinez, N.; Berón de Astrada, M.; Elia, E.M. "Obesity alters the uterine environment before pregnancy" (2018) Journal of Nutritional Biochemistry. 62:181-191
Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Obesity is a metabolic disorder that predisposes to numerous diseases and has become a major global public health concern. Cafeteria diet (CAF) is the animal model used for the study of obesity that more closely reflects Western diet habits. Previously, we described that CAF administration for 60 days induces obesity in female rats and their fetuses develop macrosomia. Given that, in our model, rats are not genetically modified and that obese mothers were fed standard chow during pregnancy, the aim of the current study was to test the hypothesis that obesity alters the intrauterine environment prior to pregnancy, and this may explain the exacerbated fetal weight gain. We found that uteri from obese rats during the estrous phase developed insulin resistance through mechanisms that involve the induction of uterine hypoxia and the down-regulation of the insulin receptor gene. Moreover, uterine cell proliferation was induced by obesity concomitantly with the reduction in the uterine contractile response to a β2 AR agonist, salbutamol, and this may be consequence of the down-regulation in the uterine β2 AR expression. We conclude that CAF-induced obesity alters the uterine environment in rats during the estrous phase and may cause the fetal macrosomia previously described by us in obese animals. The lower sensitivity of the uterus to a relaxation stimulus (salbutamol) is not a minor fact given that for implantation to occur the uterus must be relaxed for embryo nidation. Thus, the alteration in the uterine quiescence may impair implantation and, consequently, the foregoing pregnancy. © 2018 Elsevier Inc.

Registro:

Documento: Artículo
Título:Obesity alters the uterine environment before pregnancy
Autor:Bazzano, M.V.; Sarrible, G.B.; Martinez, N.; Berón de Astrada, M.; Elia, E.M.
Filiación:Universidad de Buenos Aires (UBA), Facultad de Ciencias Exactas y Naturales (FCEN), Buenos Aires, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-UBA-Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Buenos Aires, Argentina
UBA, FCEN, Departamento de Fisiología, Biología Molecular y Celular, Buenos Aires, Argentina
UBA, FCEN, Departamento de Biodiversidad y Bilogía Experimental, Buenos Aires, Argentina
UBA, Facultad de Medicina, Buenos Aires, Argentina
CONICET-UBA- Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Buenos Aires, Argentina
Palabras clave:Adrenergic receptor; Glucose; Insulin; Obesity; Uterine contractile activity; Uterus; beta 2 adrenergic receptor; insulin receptor; salbutamol; abdominal circumference; animal experiment; Article; body weight gain; cell proliferation; controlled study; down regulation; female; fetus weight; glucose transport; immunofluorescence; immunohistochemistry; insulin resistance; macrosomia; myometrium; nidation; nonhuman; obesity; polymerase chain reaction; pregnancy; pregnancy rate; protein expression; rat; real time polymerase chain reaction; RNA extraction; uterus; uterus contraction; Western blotting
Año:2018
Volumen:62
Página de inicio:181
Página de fin:191
DOI: http://dx.doi.org/10.1016/j.jnutbio.2018.09.009
Título revista:Journal of Nutritional Biochemistry
Título revista abreviado:J. Nutr. Biochem.
ISSN:09552863
CODEN:JNBIE
CAS:salbutamol, 18559-94-9, 35763-26-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09552863_v62_n_p181_Bazzano

Referencias:

  • Yamaguchi, M., Sakata, M., Ogura, K., Miyake, A., Gestational changes of glucose transporter gene expression in the mouse placenta and decidua (1996) J Endocrinol Invest, 19 (8), pp. 567-569
  • Bryant, N.J., Govers, R., James, D.E., Regulated transport of the glucose transporter GLUT4 (2002) Nat Rev Mol Cell Biol, 3, p. 267
  • Scheepers, A., Joost, H.G., Schurmann, A., The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function (2004) JPEN J Parenter Enteral Nutr, 28 (5), pp. 364-371
  • Wang, J.X., Davies, M., Norman, R.J., Body mass and probability of pregnancy during assisted reproduction treatment: retrospective study (2000) BMJ, 321 (7272), pp. 1320-1321
  • Fedorcsak, P., Dale, P.O., Storeng, R., Ertzeid, G., Bjercke, S., Oldereid, N., Impact of overweight and underweight on assisted reproduction treatment (2004) Hum Reprod, 19 (11), pp. 2523-2528
  • Lintsen, A.M.E., Pasker-de Jong, P.C.M., de Boer, E.J., Burger, C.W., Jansen, C.A.M., Braat, D.D.M., Effects of subfertility cause, smoking and body weight on the success rate of IVF (2005) Hum Reprod, 20 (7), pp. 1867-1875
  • Maheshwari, A., Stofberg, L., Bhattacharya, S., Effect of overweight and obesity on assisted reproductive technology — a systematic review (2007) Hum Reprod Update, 13 (5), pp. 433-444
  • Straus, D.S., Growth-stimulatory actions of insulin in vitro and in vivo* (1984) Endocr Rev, 5 (2), pp. 356-369
  • Strowitzki, T., von Eye, H.C., Kellerer, M., Ulrich Häring, H., Tyrosine kinase activity of insulin-like growth factor I and insulin receptors in human endometrium during the menstrual cycle: cyclic variation of insulin receptor expression (1993) Fertil Steril, 59 (2), pp. 315-322
  • Rosenbaum, D., Haber, R.S., Dunaif, A., Insulin resistance in polycystic ovary syndrome: Decreased expression of GLUT-4 glucose transporters in adipocytes (1993) Am J Physiol, 264 (2 27–2), pp. E197-E202
  • Wong, B.W., Kuchnio, A., Bruning, U., Carmeliet, P., Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes (2013) Trends Biochem Sci, 38 (1), pp. 3-11
  • Kim, J.W., Tchernyshyov, I., Semenza, G.L., Dang, C.V., HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia (2006) Cell Metab, 3 (3), pp. 177-185
  • Halberg, N., Khan, T., Trujillo, M.E., Wernstedt-Asterholm, I., Attie, A.D., Sherwani, S., Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue (2009) Mol Cell Biol, 29 (16), pp. 4467-4483
  • Zhang, H., Zhang, G., Gonzalez, F.J., Park, S.M., Cai, D., Hypoxia-inducible factor directs POMC gene to mediate hypothalamic glucose sensing and energy balance regulation (2011) PLoS Biol, 9 (7)
  • Quaegebeur, A., Segura, I., Schmieder, R., Verdegem, D., Decimo, I., Bifari, F., Deletion or inhibition of the oxygen sensor PHD1 protects against ischemic stroke via reprogramming of neuronal metabolism (2016) Cell Metab, 23 (2), pp. 280-291
  • Semenza, G.L., Hydroxylation of HIF-1: oxygen sensing at the molecular level (2004) Phys Ther, 19, pp. 176-182
  • Corrales, P., Vidal-Puig, A., Medina-Gomez, G., PPARs and metabolic disorders associated with challenged adipose tissue plasticity (2018) Int J Mol Sci, 19 (7)
  • Tontonoz, P., Spiegelman, B.M., Fat and beyond: the diverse biology of PPARgamma (2008) Annu Rev Biochem, 77, pp. 289-312
  • DeFronzo, R.A., Pharmacologic therapy for type 2 diabetes mellitus (1999) Ann Intern Med, 131 (4), pp. 281-303
  • Bazzano, M.V., Paz, D.A., Elia, E.M., Obesity alters the ovarian glucidic homeostasis disrupting the reproductive outcome of female rats (2017) J Nutr Biochem, 42, pp. 194-202
  • Bazzano, M.V., Torelli, C., Pustovrh, M.C., Paz, D.A., Elia, E.M., Obesity induced by cafeteria diet disrupts fertility in the rat by affecting multiple ovarian targets (2015) Reprod Biomed Online, 31 (5), pp. 655-667
  • Akyol, A., Langley-Evans, S.C., McMullen, S., Obesity induced by cafeteria feeding and pregnancy outcome in the rat (2009) Br J Nutr, 102 (11), pp. 1601-1610
  • Chen, S., Wasserman, D.H., MacKintosh, C., Sakamoto, K., Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking (2011) Cell Metab, 13 (1), pp. 68-79
  • Elia, E.M., Pustovrh, C., Amalfi, S., Devoto, L., Motta, A.B., Link between metformin and the peroxisome proliferator-activated receptor gamma pathway in the uterine tissue of hyperandrogenized prepubertal mice (2011) Fertil Steril, 95 (8), pp. 2534-2537. , [e1]
  • Lopez Merlo, M., Faya, M., Priotto, M., Barbeito, C., Gobello, C., Development and proliferation of feline endometrial glands from fetal life to ovarian cyclicity (2017) Theriogenology, 99, pp. 119-123
  • Chen, Q., Zhang, Y., Peng, H., Lei, L., Kuang, H., Zhang, L., Transient {beta}2-adrenoceptor activation confers pregnancy loss by disrupting embryo spacing at implantation (2011) J Biol Chem, 286 (6), pp. 4349-4356
  • Chaud, M.A., Franchi, A.M., Beron de Astrada, M., Gimeno, M.F., Role of nitric oxide on oxytocin-evoked contractions and prostaglandin synthesis in isolated pregnant rat uterus (1997) Prostaglandins Leukot Essent Fatty Acids, 57 (3), pp. 323-329
  • Parida, S., Uttam Singh, T., Ravi Prakash, V., Mishra, S.K., Molecular and functional characteristics of beta3-adrenoceptors in late pregnant mouse uterus: a comparison with beta2-adrenoceptors (2013) Eur J Pharmacol, 700 (1-3), pp. 74-79
  • Srdic, B., Stokic, E., Korac, A., Ukropina, M., Velickovic, K., Breberina, M., Morphological characteristics of abdominal adipose tissue in normal-weight and obese women of different metabolic profiles (2010) Exp Clin Endocrinol Diabetes, 118 (10), pp. 713-718
  • Armoni, M., Harel, C., Karnieli, E., Transcriptional regulation of the GLUT4 gene: from PPAR-gamma and FOXO1 to FFA and inflammation (2007) Trends Endocrinol Metab, 18 (3), pp. 100-107
  • Zelzer, E., Levy, Y., Kahana, C., Shilo, B.Z., Rubinstein, M., Cohen, B., Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT (1998) EMBO J, 17 (17), pp. 5085-5094
  • Xie, B.-Y., Lv, Q.-Y., Ning, C.-C., Yang, B.-Y., Shan, W.-W., Cheng, Y.-L., TET1-GPER-PI3K/AKT pathway is involved in insulin-driven endometrial cancer cell proliferation (2017) Biochem Biophys Res Commun, 482 (4), pp. 857-862
  • Setiawan, V.W., Yang, H.P., Pike, M.C., McCann, S.E., Yu, H., Xiang, Y.B., Type I and II endometrial cancers: have they different risk factors? (2013) J Clin Oncol, 31 (20), pp. 2607-2618
  • Rosato, V., Zucchetto, A., Bosetti, C., Dal Maso, L., Montella, M., Pelucchi, C., Metabolic syndrome and endometrial cancer risk (2011) Ann Oncol, 22 (4), pp. 884-889
  • Jawerbaum, A., Catafau, J.R., Gonzalez, E.T., Novaro, V., Gomez, G., Gelpi, E., Eicosanoid production, metabolism and contractile activity in the isolated uterus from non-insulin-dependent diabetic rats during late pregnancy (1996) Prostaglandins, 51 (5), pp. 307-320
  • Markiewicz, W., Jaroszewski, J.J., β2- and β3-adrenergic receptors stimulation relaxes porcine myometrium in the peri-implantation period1,2 (2016) J Anim Sci, 94 (11), pp. 4611-4618
  • Engstrom, T., Bratholm, P., Vilhardt, H., Christensen, N.J., Effect of pregnancy on rat myometrial beta 2-adrenoceptor mRNA and isoproterenol-induced relaxation of isolated uterine strips (1997) J Endocrinol, 153 (3), pp. 393-399
  • Liu, Y.L., Nwosu, U.C., Rice, P.J., Relaxation of isolated human myometrial muscle by beta2-adrenergic receptors but not beta1-adrenergic receptors (1998) Am J Obstet Gynecol, 179 (4), pp. 895-898
  • Coatmellec-Taglioni, G., Dausse, J.P., Ribiere, C., Giudicelli, Y., Hypertension in cafeteria-fed rats: alterations in renal alpha2-adrenoceptor subtypes (2000) Am J Hypertens, 13 (5), pp. 529-534
  • Llado, I., Rodriguez-Cuenca, S., Pujol, E., Monjo, M., Estrany, M.E., Roca, P., Gender effects on adrenergic receptor expression and lipolysis in white adipose tissue of rats (2002) Obes Res, 10 (4), pp. 296-305
  • Plut, C., Ribiere, C., Giudicelli, Y., Dausse, J.P., Gender differences in hypothalamic tyrosine hydroxylase and alpha(2)-adrenoceptor subtype gene expression in cafeteria diet-induced hypertension and consequences of neonatal androgenization (2002) J Pharmacol Exp Ther, 302 (2), pp. 525-531
  • Wu, S., Divall, S., Wondisford, F., Wolfe, A., Reproductive tissues maintain insulin sensitivity in diet-induced obesity (2012) Diabetes, 61 (1), pp. 114-123
  • Sasson, I.E., Vitins, A.P., Mainigi, M.A., Moley, K.H., Simmons, R.A., Pre-gestational vs gestational exposure to maternal obesity differentially programs the offspring in mice (2015) Diabetologia, 58 (3), pp. 615-624
  • Kim, N.S., Kang, Y.J., Jo, J.O., Kim, H.Y., Oh, Y.R., Kim, Y.O., Elevated expression of thymosin beta4, vascular endothelial growth factor (VEGF), and hypoxia inducible factor (HIF)-1alpha in early-stage cervical cancers (2011) Pathol Oncol Res, 17 (3), pp. 493-502
  • Yu, C.X., Song, J.H., Li, Y.F., Tuo, Y., Zheng, J.J., Miao, R.J., Correlation between replicative senescence of endometrial gland epithelial cells in shedding and non-shedding endometria and endometriosis cyst during menstruation (2018) Gynecol Endocrinol, pp. 1-6
  • Comstock, I.A., Diaz-Gimeno, P., Cabanillas, S., Bellver, J., Sebastian-Leon, P., Shah, M., Does an increased body mass index affect endometrial gene expression patterns in infertile patients? A functional genomics analysis (2017) Fertil Steril, 107 (3), pp. 740-748.e2
  • Provost, M.P., Acharya, K.S., Acharya, C.R., Yeh, J.S., Steward, R.G., Eaton, J.L., Pregnancy outcomes decline with increasing recipient body mass index: an analysis of 22,317 fresh donor/recipient cycles from the 2008–2010 Society for Assisted Reproductive Technology Clinic Outcome Reporting System registry (2016) Fertil Steril, 105 (2), pp. 364-368
  • Bulletti, C., de Ziegler, D., Uterine contractility and embryo implantation (2005) Curr Opin Obstet Gynecol, 17 (3), pp. 265-276
  • Khairy, M., Dhillon, R.K., Chu, J., Rajkhowa, M., Coomarasamy, A., The effect of peri-implantation administration of uterine relaxing agents in assisted reproduction treatment cycles: a systematic review and meta-analysis (2016) Reprod Biomed Online, 32 (4), pp. 362-376
  • MM, I.J., Evers, J.L., Dunselman, G.A., Volovics, L., Hoogland, H.J., Relation between endometrial wavelike activity and fecundability in spontaneous cycles (1997) Fertil Steril, 67 (3), pp. 492-496

Citas:

---------- APA ----------
Bazzano, M.V., Sarrible, G.B., Martinez, N., Berón de Astrada, M. & Elia, E.M. (2018) . Obesity alters the uterine environment before pregnancy. Journal of Nutritional Biochemistry, 62, 181-191.
http://dx.doi.org/10.1016/j.jnutbio.2018.09.009
---------- CHICAGO ----------
Bazzano, M.V., Sarrible, G.B., Martinez, N., Berón de Astrada, M., Elia, E.M. "Obesity alters the uterine environment before pregnancy" . Journal of Nutritional Biochemistry 62 (2018) : 181-191.
http://dx.doi.org/10.1016/j.jnutbio.2018.09.009
---------- MLA ----------
Bazzano, M.V., Sarrible, G.B., Martinez, N., Berón de Astrada, M., Elia, E.M. "Obesity alters the uterine environment before pregnancy" . Journal of Nutritional Biochemistry, vol. 62, 2018, pp. 181-191.
http://dx.doi.org/10.1016/j.jnutbio.2018.09.009
---------- VANCOUVER ----------
Bazzano, M.V., Sarrible, G.B., Martinez, N., Berón de Astrada, M., Elia, E.M. Obesity alters the uterine environment before pregnancy. J. Nutr. Biochem. 2018;62:181-191.
http://dx.doi.org/10.1016/j.jnutbio.2018.09.009