Bazzano, M.V.; Paz, D.A.; Elia, E.M."Obesity alters the ovarian glucidic homeostasis disrupting the reproductive outcome of female rats" (2017) Journal of Nutritional Biochemistry. 42:194-202
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Obesity constitutes a health problem of increasing worldwide prevalence related to many reproductive problems such as infertility, ovulation dysfunction, preterm delivery, fetal growth disorders, etc. The mechanisms linking obesity to these pathologies are not fully understood. Cafeteria diet (CAF) is the animal model used for the study of obesity that more closely reflects western diet habits. Previously we described that CAF induces obesity associated to hyperglycemia, reduced ovarian reserve, presence of follicular cysts and ovulatory impairments. The aim of the present study was to contribute in the understanding of the physiological mechanisms altered as consequence of obesity. For that purpose, female Wistar rats were fed ad libitum with a standard diet (control group) or CAF (Obese group). We found that CAF fed-rats developed obesity, glucose intolerance and insulin resistance. Ovaries from obese rats showed decreased glucose uptake and became insulin resistant, showing decreased ovarian expression of glucotransporter type 4 and insulin receptor gene expression respect to controls. These animals showed an increased follicular nitric oxyde synthase expression that may be responsible for the ovulatory disruptions and for inflammation, a common feature in obesity. Obese rats resulted subfertile and their pups were macrosomic. We conclude that obesity alters the systemic and the ovarian glucidic homeostasis impairing the reproductive outcome. Since macrosomia is a risk factor for metabolic and obstetric disorders in adult life, we suggest that obesity is impacting not only on health and reproduction but it is also impacting on health and reproduction of the offspring. © 2017


Documento: Artículo
Título:Obesity alters the ovarian glucidic homeostasis disrupting the reproductive outcome of female rats
Autor:Bazzano, M.V.; Paz, D.A.; Elia, E.M.
Filiación:Laboratorio de Biología del Desarrollo, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-CONICET-UBA), Pabellón 2, Cdad. Universitaria, Buenos Aires, Argentina
Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2. Cdad. Universitaria, Buenos Aires, Argentina
Palabras clave:Fertility; Glucose; Glut-4; Insulin; Obesity; Ovary; Reproductive outcome; glucose; glucose transporter 4; insulin; insulin receptor; glucose transporter 4; insulin receptor; nitric oxide synthase; Slc2a4 protein, rat; animal experiment; animal tissue; Article; body fat distribution; cafeteria diet; controlled study; diet; diet induced obesity; female; gene expression; glucose intolerance; glucose tolerance test; glucose transport; homeostasis; hyperglycemia; immunohistochemistry; insulin resistance; insulin tolerance test; macrosomia; nonhuman; obesity; ovarian glucidic homeostasis; ovary; rat; reproduction; reproductive success; animal; complication; genetics; homeostasis; metabolism; obesity; ovary follicle; pathology; pathophysiology; pregnancy; Wistar rat; Animals; Body Fat Distribution; Diet; Female; Glucose Tolerance Test; Glucose Transporter Type 4; Homeostasis; Insulin Resistance; Nitric Oxide Synthase; Obesity; Ovarian Follicle; Ovary; Pregnancy; Rats, Wistar; Receptor, Insulin
Página de inicio:194
Página de fin:202
Título revista:Journal of Nutritional Biochemistry
Título revista abreviado:J. Nutr. Biochem.
CAS:glucose, 50-99-7, 84778-64-3; glucose transporter 4, 188071-24-1; insulin, 9004-10-8; nitric oxide synthase, 125978-95-2; Glucose Transporter Type 4; Nitric Oxide Synthase; Receptor, Insulin; Slc2a4 protein, rat


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---------- APA ----------
Bazzano, M.V., Paz, D.A. & Elia, E.M. (2017) . Obesity alters the ovarian glucidic homeostasis disrupting the reproductive outcome of female rats. Journal of Nutritional Biochemistry, 42, 194-202.
---------- CHICAGO ----------
Bazzano, M.V., Paz, D.A., Elia, E.M. "Obesity alters the ovarian glucidic homeostasis disrupting the reproductive outcome of female rats" . Journal of Nutritional Biochemistry 42 (2017) : 194-202.
---------- MLA ----------
Bazzano, M.V., Paz, D.A., Elia, E.M. "Obesity alters the ovarian glucidic homeostasis disrupting the reproductive outcome of female rats" . Journal of Nutritional Biochemistry, vol. 42, 2017, pp. 194-202.
---------- VANCOUVER ----------
Bazzano, M.V., Paz, D.A., Elia, E.M. Obesity alters the ovarian glucidic homeostasis disrupting the reproductive outcome of female rats. J. Nutr. Biochem. 2017;42:194-202.