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Lacau‐Mengido, I.M.; Becú‐Villalobos, D.; Thyssen, S.M.; Rey, E.B.; Lux‐Lantos, V.A.R.; Libertun, C. "Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats" (1993) Journal of Neuroendocrinology. 5(6):705-709
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Abstract:

In previous studies we have shown that the developing rat provides an interesting physiologic model in which the dopaminergic control of both LH and FSH is well defined in contrast to the controversial results obtained in adult rats. We wished to establish the role of testosterone in antidopaminergic induced gonadotrophins release in 12 day‐old male and female rats, and evaluate the effect of antidopaminergic drugs at the hypothalamic level during this developmental stage. Haloperidol, an antidopaminergic drug, increased both LH and FSH in female 12 day‐old rats but not in male littermates. The effect was blocked by bromocriptine and not by phentolamine indicating that haloperidol acted on the dopaminergic receptor, and that unspecific stimulation of the noradrenergic system was not involved. Haloperidol was ineffective when female rats were previously ovariectomized and injected with testosterone propionate at 9 days of age. If females were treated on the day of birth with testosterone propionate, haloperidol‐induced FSH and LH release was also abolished. In control males haloperidol had no effect on the release of LH or FSH. But if males were orchidectomized at birth or at 9 days of age, haloperidol released both LH and FSH during the infantile period. In an attempt to establish the site of action of antidopaminergic drugs on gonadotrophin release, hypothalami (mediobasal and preoptic‐suprachiasmatic area) from 12 day‐old infant female rats were perfused with either haloperidol or domperidone (2±10−6 M). Both drugs increased LHRH release into the perifusate. Besides haloperidol did not modify the release of LH or FSH from adenohypophyseal cells incubated in vitro. We therefore conclude that antidopaminergic‐induced gonadotrophins release is modulated by serum testosterone concentrations, and that the site of action is probably the LHRH‐secreting neuron of the hypothalamus. Copyright © 1993, Wiley Blackwell. All rights reserved

Registro:

Documento: Artículo
Título:Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats
Autor:Lacau‐Mengido, I.M.; Becú‐Villalobos, D.; Thyssen, S.M.; Rey, E.B.; Lux‐Lantos, V.A.R.; Libertun, C.
Filiación:Instituto de Biologia Y Medicina Experimental, Obligado 2490, Buenos Aires, 1428, Argentina
Palabras clave:antidopaminergic drugs; development; FSH; LH; LHRH; bromocriptine; domperidone; dopamine receptor; dopamine receptor blocking agent; follitropin; gonadorelin; gonadotropin; haloperidol; luteinizing hormone; phentolamine; phentolamine mesylate; testosterone; testosterone propionate; adenohypophysis; age; animal cell; animal experiment; animal tissue; article; controlled study; dopaminergic system; female; follitropin release; gonadorelin release; gonadotropin release; hormone action; hypophysis; hypophysis cell; hypothalamus; intraperitoneal drug administration; luteinizing hormone release; male; nonhuman; orchiectomy; ovariectomy; postnatal development; preoptic area; priority journal; rat; suprachiasmatic nucleus; testosterone blood level; Adrenergic alpha-Antagonists; Animal; Animals, Newborn; Bromocriptine; Cells, Cultured; Dopamine Antagonists; Female; Follicle Stimulating Hormone; Gonadorelin; Haloperidol; Hypothalamus; In Vitro; Luteinizing Hormone; Male; Orchiectomy; Phentolamine; Pituitary Gland; Rats; Rats, Sprague-Dawley; Sex Differentiation; Stimulation, Chemical; Support, Non-U.S. Gov't
Año:1993
Volumen:5
Número:6
Página de inicio:705
Página de fin:709
DOI: http://dx.doi.org/10.1111/j.1365-2826.1993.tb00543.x
Título revista:Journal of Neuroendocrinology
Título revista abreviado:J. Neuroendocrinol.
ISSN:09538194
CAS:Adrenergic alpha-Antagonists; Bromocriptine, 25614-03-3; Dopamine Antagonists; Follicle Stimulating Hormone, 9002-68-0; Gonadorelin, 33515-09-2; Haloperidol, 52-86-8; Luteinizing Hormone, 9002-67-9; Phentolamine, 50-60-2
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09538194_v5_n6_p705_Lacau-Mengido

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Citas:

---------- APA ----------
Lacau‐Mengido, I.M., Becú‐Villalobos, D., Thyssen, S.M., Rey, E.B., Lux‐Lantos, V.A.R. & Libertun, C. (1993) . Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats. Journal of Neuroendocrinology, 5(6), 705-709.
http://dx.doi.org/10.1111/j.1365-2826.1993.tb00543.x
---------- CHICAGO ----------
Lacau‐Mengido, I.M., Becú‐Villalobos, D., Thyssen, S.M., Rey, E.B., Lux‐Lantos, V.A.R., Libertun, C. "Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats" . Journal of Neuroendocrinology 5, no. 6 (1993) : 705-709.
http://dx.doi.org/10.1111/j.1365-2826.1993.tb00543.x
---------- MLA ----------
Lacau‐Mengido, I.M., Becú‐Villalobos, D., Thyssen, S.M., Rey, E.B., Lux‐Lantos, V.A.R., Libertun, C. "Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats" . Journal of Neuroendocrinology, vol. 5, no. 6, 1993, pp. 705-709.
http://dx.doi.org/10.1111/j.1365-2826.1993.tb00543.x
---------- VANCOUVER ----------
Lacau‐Mengido, I.M., Becú‐Villalobos, D., Thyssen, S.M., Rey, E.B., Lux‐Lantos, V.A.R., Libertun, C. Antidopaminergic‐lnduced Hypothalamic LHRH Release and Pituitary Gonadotrophin Secretion in 12 Day‐Old Female and Male Rats. J. Neuroendocrinol. 1993;5(6):705-709.
http://dx.doi.org/10.1111/j.1365-2826.1993.tb00543.x