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Abstract:

Ample evidence suggests that, when reactivated by a reminder, a consolidated memory may return to a labile state and needs to be stabilized again in order to persist, a process known as reconsolidation. In a previous study, performed in the crab Chasmagnathus, we found a dual role for the biogenic amine octopamine (OA) during memory consolidation. On the one hand, it was necessary for appetitive memory formation and, on the other, it had a deleterious effect on aversive memory consolidation. Thus, OA could be a good candidate to dissect the neurochemical mechanisms of appetitive and aversive reconsolidation. Here, we initially characterized the reconsolidation of an appetitive memory. Then, we compared appetitive reconsolidation with its aversive counterpart regarding the implication of OA in these processes, and contrasted them with previous findings obtained in the consolidation phase. Our results demonstrate that appetitive reconsolidation takes place when animals are re-exposed to the training context, as shown by the amnesic effect of cycloheximide when applied before the reminder. In addition, the no-reinforcement during the reminder is a necessary condition for appetitive reconsolidation to occur. Remarkably, appetitive reconsolidation is neither impaired by OA receptor antagonists nor facilitated by exogenous OA, whereas aversive reconsolidation can be interfered with by OA administration. Thus, our results indicate that appetitive reconsolidation does not involve OA signaling, while aversive reconsolidation is negatively modulated by OA. All in all, these results could constitute a step towards the identification of particular features of appetitive and aversive reconsolidation. © 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.

Registro:

Documento: Artículo
Título:Dissecting mechanisms of reconsolidation: Octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus
Autor:Kaczer, L.; Klappenbach, M.; Maldonado, H.
Filiación:Laboratorio de Neurobiología de la Memoria, Departamento de Fisiología y Biología Molecular y Celular, IFIBYNE-CONICET, Pabellón II, Facultad de Ciencias Exactas y Naturales C1428EHA, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Appetitive conditioning; Aversive conditioning; Biogenic amine; Invertebrates; Memory reconsolidation; octopamine; animal experiment; appetitive memory; article; aversive memory; Chasmagnathus; conditioning; controlled study; crab; information retrieval; male; memory; memory consolidation; neurochemistry; nonhuman; priority journal; protein synthesis; reinforcement; sequence homology; signal transduction; Adrenergic alpha-Agonists; Animals; Association Learning; Brachyura; Male; Memory; Octopamine
Año:2011
Volumen:34
Número:7
Página de inicio:1170
Página de fin:1178
DOI: http://dx.doi.org/10.1111/j.1460-9568.2011.07830.x
Título revista:European Journal of Neuroscience
Título revista abreviado:Eur. J. Neurosci.
ISSN:0953816X
CODEN:EJONE
CAS:octopamine, 104-14-3; Adrenergic alpha-Agonists; Octopamine, 104-14-3
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0953816X_v34_n7_p1170_Kaczer

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Citas:

---------- APA ----------
Kaczer, L., Klappenbach, M. & Maldonado, H. (2011) . Dissecting mechanisms of reconsolidation: Octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus. European Journal of Neuroscience, 34(7), 1170-1178.
http://dx.doi.org/10.1111/j.1460-9568.2011.07830.x
---------- CHICAGO ----------
Kaczer, L., Klappenbach, M., Maldonado, H. "Dissecting mechanisms of reconsolidation: Octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus" . European Journal of Neuroscience 34, no. 7 (2011) : 1170-1178.
http://dx.doi.org/10.1111/j.1460-9568.2011.07830.x
---------- MLA ----------
Kaczer, L., Klappenbach, M., Maldonado, H. "Dissecting mechanisms of reconsolidation: Octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus" . European Journal of Neuroscience, vol. 34, no. 7, 2011, pp. 1170-1178.
http://dx.doi.org/10.1111/j.1460-9568.2011.07830.x
---------- VANCOUVER ----------
Kaczer, L., Klappenbach, M., Maldonado, H. Dissecting mechanisms of reconsolidation: Octopamine reveals differences between appetitive and aversive memories in the crab Chasmagnathus. Eur. J. Neurosci. 2011;34(7):1170-1178.
http://dx.doi.org/10.1111/j.1460-9568.2011.07830.x