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Abstract:

The effects of platelet activating factor (PAF) on glucose oxidation in uterine strips isolated from rats in the 4 th and 5 th day of pregnancy, were explored. PAF, at a concentration of 10-10 and 10-8 M, augmented significantly the generation of 14CO2 from labelled glucose in uteri from pregnant rats in the 4 th day of pregnancy. When the tissue was obtained from 5 days pregnant rats, the addition of PAF at 10-8 increased significantly more than PAF at 10-10 M the metabolism of glucose. On the other hand, PAF at 10-8 M failed to alter the uterine basal production of 14CO2 from labelled glucose in animals at estrus. BN52021, a specific PAF antagonist employed at 10-5 M, blocked completely the action of PAF in the pregnant rat uterus. PGE1, PGE2 and PGF2α enhanced significantly the formation of 14CO2 from labelled glucose in uteri from 5 days pregnant rats. Indomethacin, a well known inhibitor of prostaglandin synthesis, did not alter the basal glucose metabolism in uteri from 5 days pregnant rats, but antagonized completely the stimulating action of PAF on 14CO2 production from labelled glucose an effect that was partially reverted by the addition of PGE1, PGE2 or PGF2α (10-7 M). Furthermore, nordihydroguaiaretic acid (NDHGA), a specific inhibitor of 5-lipoxygenase at 10-5 M, as well as FPL-55712, an antagonist of leukotrienes (LTs), at the same concentration, blocked the action of PAF on the metabolism of glucose. The action of NDHGA was partially counteracted by the addition of LTC4 at 10-7 M. Considering all these results, we suggest that PAF stimulates indirectly glucose metabolism via the "de novo" synthesis of PGs anb LTs, probably by the activation of phospholipase A2 (PLA2). As far as we know the present report represent the first description of a stimulating action of PAF on glucose metabolism in pregnant rat uteri. © 1990.

Registro:

Documento: Artículo
Título:A novel enhancing effect of platelet activating factor (PAF) on glucose oxidation in uteri from pregnant rats. Participation of prostaglandins and leukotrienes
Autor:González, E.; Gimeno, A.L.; Gimeno, M.A.F.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET), Universidad de Buenos Aires, Argentina
Departamento de Farmacología y Toxicología, Facultad de Medicina, Universidad de Buenos Aires, Argentina
Palabras clave:7 [3 (4 acetyl 3 hydroxy 2 propylphenoxy) 2 hydroxypropoxy] 4 oxo 8 propyl 4h 1 benzopyran 2 carboxylic acid; ginkgolide b; indometacin; leukotriene c4; nordihydroguaiaretic acid; prostaglandin e1; prostaglandin e2; prostaglandin f2 alpha; radioisotope; thrombocyte activating factor; animal cell; article; female; glucose metabolism; nonhuman; pregnancy; priority journal; rat; thrombocyte; tissue culture; uterus; Animal; Carbon Monoxide; Chromones; Female; Glucose; Indomethacin; Leukotrienes; Nordihydroguaiaretic Acid; Platelet Activating Factor; Pregnancy; Pregnancy, Animal; Prostaglandins; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Uterus; Animalia
Año:1990
Volumen:40
Número:1
Página de inicio:79
Página de fin:84
DOI: http://dx.doi.org/10.1016/0952-3278(90)90121-Z
Título revista:Prostaglandins, Leukotrienes and Essential Fatty Acids
Título revista abreviado:Prostaglandins Leukotrienes Essent. Fatty Acids
ISSN:09523278
CODEN:PLEAE
CAS:Carbon Monoxide, 630-08-0; Chromones; FPL 55712, 40786-08-1; Glucose, 50-99-7; Indomethacin, 53-86-1; Leukotrienes; Nordihydroguaiaretic Acid, 500-38-9; Platelet Activating Factor; Prostaglandins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09523278_v40_n1_p79_Gonzalez

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Citas:

---------- APA ----------
González, E., Gimeno, A.L. & Gimeno, M.A.F. (1990) . A novel enhancing effect of platelet activating factor (PAF) on glucose oxidation in uteri from pregnant rats. Participation of prostaglandins and leukotrienes. Prostaglandins, Leukotrienes and Essential Fatty Acids, 40(1), 79-84.
http://dx.doi.org/10.1016/0952-3278(90)90121-Z
---------- CHICAGO ----------
González, E., Gimeno, A.L., Gimeno, M.A.F. "A novel enhancing effect of platelet activating factor (PAF) on glucose oxidation in uteri from pregnant rats. Participation of prostaglandins and leukotrienes" . Prostaglandins, Leukotrienes and Essential Fatty Acids 40, no. 1 (1990) : 79-84.
http://dx.doi.org/10.1016/0952-3278(90)90121-Z
---------- MLA ----------
González, E., Gimeno, A.L., Gimeno, M.A.F. "A novel enhancing effect of platelet activating factor (PAF) on glucose oxidation in uteri from pregnant rats. Participation of prostaglandins and leukotrienes" . Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 40, no. 1, 1990, pp. 79-84.
http://dx.doi.org/10.1016/0952-3278(90)90121-Z
---------- VANCOUVER ----------
González, E., Gimeno, A.L., Gimeno, M.A.F. A novel enhancing effect of platelet activating factor (PAF) on glucose oxidation in uteri from pregnant rats. Participation of prostaglandins and leukotrienes. Prostaglandins Leukotrienes Essent. Fatty Acids. 1990;40(1):79-84.
http://dx.doi.org/10.1016/0952-3278(90)90121-Z