Navegar

Colección

Datos Estadísticas

Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

The effects of electric field stimulation (EFS) on the outputs of prostaglandins (PGs) E1, E2 and F2α from isolated contracting rat urinary bladders, were explored. Also, the influences of papaverine (5.10-6 M) and of tetradotoxin (TTX = 5.10-7 M) on PGs released by spontaneously contracting or electrically driven preparations, were tested. The basal control outputs of the three PGs in spontaneously contracting urinary bladders, had a comparable magnitude. On the contrary, in electrically stimulated preparations the output of PGE2 rose significantly; that of PGF2α presented a significant reduction and the release of PGE1 was similar to that in controls. Papaverine failed to modify the profile of basal control PG release in non-stimulated bladders, abolished contractile responses to EFS and blocked the augmented output of PGE2 elicited by EFS. The presence of TTX in the suspending solution had no action on the basal control release of PGs from non-stimulated spontaneously contracting preparations, depressed between 80-90% the inotropic responses triggered by EFS and completely antagonized the enhanced output of PGE2 evoked by EFS. Results are discussed in terms of the relative participations of the evoked inotropism of the detrusor muscle or by the stimulation of nerve endings, accounting for the greater release of tissue PGE2 after EFS. © 1989.

Registro:

Documento: Artículo
Título:Electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. Influences of papaverine and tetradotoxin
Autor:Dveksler, G.; Franchi, A.M.; Gonzalez, E.T.; Gimeno, M.A.F.; Gimeno, A.L.
Filiación:Centro de Estudios Farmacológicos y de Principios Naturales (CEFAPRIN), Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina (CONICET), Universidad de Buenos Aires, Argentina
Departmento de Farmacologia y Toxicologia, Facultad de Medicina, Universidad de Buenos Aires, Argentina
Palabras clave:papaverine; prostaglandin e1; prostaglandin e2; prostaglandin f2 alpha; tetrodotoxin; animal cell; bladder; nonhuman; priority journal; rat; Alprostadil; Animal; Bladder; Dinoprost; Dinoprostone; Electric Stimulation; Female; In Vitro; Muscle Contraction; Papaverine; Prostaglandins; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Synaptic Transmission; Tetrodotoxin
Año:1989
Volumen:36
Número:2
Página de inicio:65
Página de fin:68
DOI: http://dx.doi.org/10.1016/0952-3278(89)90019-7
Título revista:Prostaglandins, Leukotrienes and Essential Fatty Acids
Título revista abreviado:Prostaglandins Leukotrienes Essent. Fatty Acids
ISSN:09523278
CODEN:PLEAE
CAS:papaverine, 58-74-2, 61-25-6; prostaglandin E1, 745-65-3; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; tetrodotoxin, 4368-28-9, 4664-41-9; Alprostadil, 745-65-3; Dinoprost, 551-11-1; Dinoprostone, 363-24-6; Papaverine, 58-74-2; Prostaglandins; Tetrodotoxin, 4368-28-9
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09523278_v36_n2_p65_Dveksler

Referencias:

  • Dveksler, Gimeno, Gimeno, Involvement of some eicosanoids in the cholinergic and non-cholinergic inotropic responses evoked by electric field stimulation in the isolated rat urinary bladder (1987) Pharmac. Res. Comm., 19, pp. 295-309
  • Choo, Mitchelson, The role of prostaglandins in the excitatory innervation of the rat urinary bladder (1977) Prostaglandins, 13, pp. 917-926
  • Abrams, Sykes, Rose, Rogers, The synthesis and release of prostaglandins by human urinary bladder muscle in vitro (1979) Investigative Urology, 16, pp. 346-348
  • Poggesi, Nicita, Castellani, Selli, Galanti, Turini, Masotti, The role of prostaglandins in the maintenance of the tone of the rabbit urinary bladder (1980) Investigative Urology, 17, pp. 454-458
  • Jeremy, Mikhailidis, Dandona, The rat urinary bladder produces prostacyclin as well as other prostaglandins (1984) Prost. Leuk. & Med., 16, pp. 235-248
  • Jeremy, Mikhailidis, Dandona, Prostanoid synthesis by the rat urinary bladder: evidence for stimulation through muscarine receptor-linked calcium channels (1986) Naunyn. Schm. Arch. Pharmacol., 334, pp. 463-467
  • Gershon, Effects of tetrodotoxin on innervated smooth muscle preparation (1967) Br. J. Pharmac. Chemother, 29, pp. 259-279
  • Tashiro, Tomita, The effects of papaverine on the electrical and mechanical activity of the guinea pig taenia coli (1970) Br. J. Pharmac., 39, pp. 608-618
  • Santi, Ferrari, Contessa, On the mechanism of spasmolytic effect of papaverine and certain derivatives (1964) Biochim. Pharmac., 13, pp. 153-160
  • Gimeno, Borda, Sterin-Borda, Vidal, Gimeno, Pharmacologic influences on human ovarian contractions (1976) Obstet. Gynec. (N.Y.), 47, pp. 218-222
  • Willis, Simplified thin lager chromatography of protaglandins in biological extracts (1970) Br. J. Pharm., 40, p. 583
  • Vane, The use of isolated organs for detection active substances in the circulatory blood (1964) Br. J. Pharm. Chemother, 23, pp. 360-373
  • Gilmore, Vane, Willie, Prostaglandins released by the Spleen (1968) Nature, 218, pp. 135-145
  • Coceani, Pace-Asciak, Volta, Wolfe, Effect of nerve stimulation on prostaglandin formation and release from the rat stomach (1967) Amer. J. Physiol., 213, pp. 1056-1064
  • Justad, Wennmalm, RELEASE OF PROSTAGLANDIN FROM THE RABBIT ISOLATED HEART FOLLOWING VAGAL NERVE STIMULATION OR ACETYLCHOLINE INFUSION (1974) British Journal of Pharmacology, 52, pp. 375-386
  • Alkondon, Ganguly, Release of prostaglandin E from isolated urinary bladder of the guinea pig (1980) Br. J. Pharmac., 69, pp. 573-579
  • Gustafsson, Hedquist, Lagercrantz, Potentiation by prostaglandins E1, E2 and F2α of the contraction response to transmural stimulation in the bovine iris sphincter muscle (1975) Acta Physiol. Scand., 95, pp. 26-35
  • Wennmol, Hedqvist, Inhibition by prostaglandin E1 of parasympathetic neurotransmission in the rabbit heart (1971) Life Sci., 10, pp. 465-472
  • Hills, Prostaglandins and tone in isolated strips of mammalian bladder (1976) Br. J. Pharmac., 57, pp. 464-465
  • Chaud, Franchi, Gonzlez, Gimeno, Gimeno, Norepinephrine alters PGE2/PGE1 output ratio in isolated uterus from ovariectomized rats (1986) Prost. Leuk. Med., 22, pp. 201-210
  • Rubiales, Barioglio, Lacuara, Release of prostaglandins E and F from rat uterine strips incubated in depolarizing and hyperpolarizing solutions (1985) Prostaglandins, Leukotrienes and Medicine, 20, pp. 129-138

Citas:

---------- APA ----------
Dveksler, G., Franchi, A.M., Gonzalez, E.T., Gimeno, M.A.F. & Gimeno, A.L. (1989) . Electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. Influences of papaverine and tetradotoxin. Prostaglandins, Leukotrienes and Essential Fatty Acids, 36(2), 65-68.
http://dx.doi.org/10.1016/0952-3278(89)90019-7
---------- CHICAGO ----------
Dveksler, G., Franchi, A.M., Gonzalez, E.T., Gimeno, M.A.F., Gimeno, A.L. "Electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. Influences of papaverine and tetradotoxin" . Prostaglandins, Leukotrienes and Essential Fatty Acids 36, no. 2 (1989) : 65-68.
http://dx.doi.org/10.1016/0952-3278(89)90019-7
---------- MLA ----------
Dveksler, G., Franchi, A.M., Gonzalez, E.T., Gimeno, M.A.F., Gimeno, A.L. "Electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. Influences of papaverine and tetradotoxin" . Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 36, no. 2, 1989, pp. 65-68.
http://dx.doi.org/10.1016/0952-3278(89)90019-7
---------- VANCOUVER ----------
Dveksler, G., Franchi, A.M., Gonzalez, E.T., Gimeno, M.A.F., Gimeno, A.L. Electric field stimulation alters the outputs of prostaglandins from isolated rat urinary bladder preparations. Influences of papaverine and tetradotoxin. Prostaglandins Leukotrienes Essent. Fatty Acids. 1989;36(2):65-68.
http://dx.doi.org/10.1016/0952-3278(89)90019-7