Artículo
Faletti, A.; Chaud, M.A.; Gimeno, M.A.F.; Gimeno, A.L. "Morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin E2, but not of prostaglandin F2α and inhibits prostaglandin E and F outputs from the uterus of ovariectomized rats" (1988) Prostaglandins, Leukotrienes and Essential Fatty Acids. 34(3):147-151
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Abstract:
The effects of morphine on the constancy of spontaneous contractions (isometric developed tension = IDT and contractile frequency = CF), in uterine strips isolated from ovariectomized rats and the influence of naloxone, were explored. The inotropic responses to added prostaglandins (PGs) E2 and F2α and the influences of morphine and of morphine in the presence of naloxone on PG actions, were also determined. Moreover, the synthesis and outputs of PGs E and F from uteri and the effects of morphine alone and of morphine plus naloxone, were studied. Morphine (10-6 M) significantly depressed uterine constancy of IDT during the first hours following delivery, but its action on CF did not differ from controls. Naloxone, neither at 10-8 M nor at 10-6 M, altered the negative inotropoic influence of morphine on IDT. Exogenous PGs E2 and F2α, stimulated uterine inotropism in a concentration-dependent fashion. Morphine altered dose-response curves for exogenous PGE2, evoking a parallel surmountable shift to the right, but did not affect the inotropic action of added PGF2α. This antagonistic effect of the opioid was not altered by preincubation with naloxone. Basal synthesis and outputs of PGs E and F in uteri from ovariectomized rats were significantly depressed by morphine (10-6 M) but not altered by incubating tissues with morphine in presence of naloxone. Results are discussed in terms of a presumptive dual action of morphine on uterine motility, i.e., antagonizing PGE2 receptors and inhibiting the synthesis of some PGs by the uterus. These influences of morphine do not appear to be subserved by the activation of μ opioid receptors. Moreover, the possibility that endogenous opioids could play a relevant role modulating uterine PG influences, is also discussed. © 1988.
Registro:
| Documento: | Artículo |
| Título: | Morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin E2, but not of prostaglandin F2α and inhibits prostaglandin E and F outputs from the uterus of ovariectomized rats |
| Autor: | Faletti, A.; Chaud, M.A.; Gimeno, M.A.F.; Gimeno, A.L. |
| Filiación: | Centro de Estudios Farmacológicos, Principios Naturales (CEFAPRIN) from the Consejo Nacional de Investigaciones Cientificas y Tecnicas, 1414 Buenos Aires, Argentina Departamento de Farmacologia y Toxicologia, Facultad de Medicina, Universidad de Buenos Aires. Serrano 665, 1414 Buenos Aires, Argentina |
| Palabras clave: | morphine; naloxone; prostaglandin e2; prostaglandin f2 alpha; animal experiment; controlled study; female; nonhuman; ovariectomy; priority journal; rat; uterus; uterus contraction; Animal; Dinoprost; Dinoprostone; Female; Morphine; Naloxone; Ovariectomy; Prostaglandins E; Prostaglandins F; Rats; Rats, Inbred Strains; Stimulation, Chemical; Uterine Contraction; Uterus |
| Año: | 1988 |
| Volumen: | 34 |
| Número: | 3 |
| Página de inicio: | 147 |
| Página de fin: | 151 |
| DOI: | http://dx.doi.org/10.1016/0952-3278(88)90138-X |
| Título revista: | Prostaglandins, Leukotrienes and Essential Fatty Acids |
| Título revista abreviado: | Prostaglandins Leukotrienes Essent. Fatty Acids |
| ISSN: | 09523278 |
| CODEN: | PLEAE |
| CAS: | morphine, 52-26-6, 57-27-2; naloxone, 357-08-4, 465-65-6; prostaglandin E2, 363-24-6; prostaglandin F2 alpha, 551-11-1; Dinoprost, 551-11-1; Dinoprostone, 363-24-6; Morphine, 57-27-2; Naloxone, 465-65-6; Prostaglandins E; Prostaglandins F |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09523278_v34_n3_p147_Faletti |
Referencias:
- Bekemeier, Giessler, Vogel, Influence of MAO-inhibitors, neuroleptics, morphine, mescaline, divascan aconitine and pyrogenes on prostaglandin biosynthesis (1977) Pharm. Res. Comm., 9, p. 587
- Collier, McDonald-Gibson, Saeed, Stimulation of prostaglandin biosynthesis by drugs: effects in vitro of some drugs affecting gut function (1976) Br. J. Pharmacol., 58, p. 193
- Jaques, Morphine as inhibitor of prostaglandin E1 in the isolated guinea pig intestine (1969) Experientia, 25, p. 1059
- Sanner, Prostaglandin inhibition with dibenzoscazepine hydrazide derivative and morphine (1971) Ann. New York Acad. Sci., 180, p. 396
- Contreras, Tamayo, Juica, Sensitivity changes after morphine treatment in the mouse uterus (1982) Arch. int. Pharmacodyn, 255, p. 39
- Jivegard, Svanvik, The influence of morphine loperamide and naloscone on gallbladder response to prostaglandin E2 in the anaesthetized cat (1986) Acta Physiol. Scand., 127, p. 275
- Widy-Tyszkiewicz, Luczar, Gumulka, Wand Szreniawski, Antagonism by morphine and pethidine of the contractile effects of PGE2 on isolated uterus of the rat (1978) Arch. int. Pharmacodyn, 232, p. 53
- Franchi, Chaud, Borda, Gimeno, Lazzari, Gimeno, Spontaneous motility and prostaglandin generation in rat uterine horns isolated during the estrous cycle (1981) Prostaglandins, 22, p. 637
- Sterin-Speziale, Gimeno, Bonacossa, Gimeno, The effect of estradiol on isolated rat uterine motility and on prostaglandin generation (1980) Prostaglandins, 20, p. 233
- Bonacossa, Sterin-Speziale, Gimeno, Gimeno, Effect of corticosterone, hydrocortirone and prostaglandin fatty acid precursors on the spontaneous motility of the uterus isolated from ovariectomized rats (1982) Prostaglandine, 23, p. 113
- Chaud, Gonzales, Franchi, Gimeno, Gimeno, Sex hormones and the motility of and prostaglandin output from uterine horns of immature rats (1984) Prost. Leuk. Med., 15, p. 35
- Gimeno, Borda, Sterin-Borda, Vidal, Gimeno, Pharmacologic influences on human ovarian contractions (1976) Obstet. Gynec. N.Y., 47, p. 218
- Vane, THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD (1964) British Journal of Pharmacology and Chemotherapy, 23, p. 36
- Gilmore, Vane, Willie, Prostaglandins released by the Spleen (1968) Nature, 218, p. 135
- Sawynok, Pinsky, Labella, On the specificity of maloscine as an opiate antagonist (1979) Life Sci., 25, p. 1621
- Simon, Hiller, Edelman, Stereospecific binding of the potent narcotic analgesic 3H-ehtorpine to rat brain homogenate (1973) Proceedings of the National Academy of Sciences, 70, p. 1947
- Abraham, Dhume, Diniz, Pereira, Effect of met-enkephalin on the responses of rat fundus and colon and chicken rectum to PGE2 and its release from rat aortic strips (1980) Pharm. Res. Comm., 12, p. 131
- Gryglewski, Szczeklik, Bleron, Morphine antagonises prostaglandin E1 mediated inhibition of human platelet aggregation (1975) Nature, 256, p. 56
- Chang, Cuatrecasas, Heterogeneity and properties of opiate receptors (1981) Fed. Proc., 40, p. 2729
- Petraglia, Fachinetti, Fuia, Ruspa, Bonavera, Gandolfi, Genazzani, Endogenous opioid peptides in uterine fluid (1986) Fertil. Steril., 46, p. 247
- Wahlstrom, Laatikainen, Salminen, Leppaluoto, Immunoreactive B endophin is demonstrable in the secretory but not in the proliferative endometrium (1985) Life Sci., 36, p. 987
Citas:
---------- APA ----------
Faletti, A., Chaud, M.A., Gimeno, M.A.F. & Gimeno, A.L. (1988) . Morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin E2, but not of prostaglandin F2α and inhibits prostaglandin E and F outputs from the uterus of ovariectomized rats. Prostaglandins, Leukotrienes and Essential Fatty Acids, 34(3), 147-151.http://dx.doi.org/10.1016/0952-3278(88)90138-X
---------- CHICAGO ----------
Faletti, A., Chaud, M.A., Gimeno, M.A.F., Gimeno, A.L. "Morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin E2, but not of prostaglandin F2α and inhibits prostaglandin E and F outputs from the uterus of ovariectomized rats" . Prostaglandins, Leukotrienes and Essential Fatty Acids 34, no. 3 (1988) : 147-151.http://dx.doi.org/10.1016/0952-3278(88)90138-X
---------- MLA ----------
Faletti, A., Chaud, M.A., Gimeno, M.A.F., Gimeno, A.L. "Morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin E2, but not of prostaglandin F2α and inhibits prostaglandin E and F outputs from the uterus of ovariectomized rats" . Prostaglandins, Leukotrienes and Essential Fatty Acids, vol. 34, no. 3, 1988, pp. 147-151.http://dx.doi.org/10.1016/0952-3278(88)90138-X
---------- VANCOUVER ----------
Faletti, A., Chaud, M.A., Gimeno, M.A.F., Gimeno, A.L. Morphine diminishes the constancy of spontaneous uterine contractions, antagonizes the positive inotropic effects of prostaglandin E2, but not of prostaglandin F2α and inhibits prostaglandin E and F outputs from the uterus of ovariectomized rats. Prostaglandins Leukotrienes Essent. Fatty Acids. 1988;34(3):147-151.http://dx.doi.org/10.1016/0952-3278(88)90138-X
