Artículo
Nonami, H.; Wu, F.; Thummel, R.P.; Fukuyama, Y.; Yamaoka, H.; Erra-Balsells, R. "Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry" (2001) Rapid Communications in Mass Spectrometry. 15(23):2354-2373
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Abstract:
In an effort to gain an understanding of the processes governing ultraviolet matrix-assisted laser desorption/ionization (UV-MALDI), direct comparison was made of the mass spectra of proteins, carbohydrates and synthetic polymers (polyethylene glycol, polyester and polyamide) by using pyridylindoles, pyridoindoles and pyridylpyridoindoles as UV (337 nm)-MALDI-TOFMS matrices in positive and negative ion mode. In order to study the combined effect of the indole N-H and the pyridine nitrogen of the MALDI matrix on the desorption/ionization process in MALDI, compounds were selected that include either or both of these functions in their structure. Within the compounds studied only those that possess simultaneously both functions in a 1,4-relation behave as very good matrices for proteins. These compounds also work as matrices for some carbohydrates and synthetic polymers used as analytes in the present study. Some of the compounds were also found to be useful for the post-source decay (PSD) analysis of cyclodextrins in positive and negative ion mode. In several cases we also examined the matrix behavior of the corresponding N-methylindole derivatives. Copyright © 2001 John Wiley & Sons, Ltd.
Registro:
| Documento: | Artículo |
| Título: | Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry |
| Autor: | Nonami, H.; Wu, F.; Thummel, R.P.; Fukuyama, Y.; Yamaoka, H.; Erra-Balsells, R. |
| Filiación: | Plant Biophysics/Biochemistry Research Laboratory, College of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama 790-8566, Japan Department of Chemistry, University of Houston, Houston, TX 77204-5641, United States Shimadzu Coorporation, 1 Nishinokyo-Kuwabaracho, Nakagyo-ku, Kyoto 604-6511, Japan Departamento de Química Orgánica, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, c.c. 74 - suc. 30, 1430 Buenos Aires, Argentina Dep. Quím. Org., FCEyN, UBA, c.c. 74 - suc. 30, 1430 Buenos Aires, Argentina |
| Palabras clave: | 2,5-dihydroxybenzoic acid; bipyridine derivative; carbohydrate; carboline derivative; cyclodextrin; gentisic acid; harman; harmine; hydrogen; hydroxybenzoic acid derivative; indole derivative; maneb; nitrogen; polymer; protein; pyridine derivative; pyrifenox mancozeb; pyrifenox-mancozeb; zineb; article; carbohydrate analysis; chemistry; crystallization; desorption; drug combination; ionization; mass spectrometry; methodology; protein analysis; protein structure; ultraviolet radiation; ultraviolet spectrophotometry; Carbohydrates; Crystallization; Drug Combinations; Gentisates; Harmine; Hydroxybenzoic Acids; Indoles; Maneb; Polymers; Proteins; Pyridines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Ultraviolet; Zineb |
| Año: | 2001 |
| Volumen: | 15 |
| Número: | 23 |
| Página de inicio: | 2354 |
| Página de fin: | 2373 |
| DOI: | http://dx.doi.org/10.1002/rcm.514 |
| Título revista: | Rapid Communications in Mass Spectrometry |
| Título revista abreviado: | Rapid Commun. Mass Spectrom. |
| ISSN: | 09514198 |
| CODEN: | RCMSE |
| CAS: | 2,5-dihydroxybenzoic acid, 490-79-9; Carbohydrates; Drug Combinations; Gentisates; harman, 486-84-0; Harmine, 442-51-3; Hydroxybenzoic Acids; Indoles; Maneb, 12427-38-2; Polymers; Proteins; Pyridines; pyrifenox-mancozeb; Zineb, 12122-67-7 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09514198_v15_n23_p2354_Nonami |
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Citas:
---------- APA ----------
Nonami, H., Wu, F., Thummel, R.P., Fukuyama, Y., Yamaoka, H. & Erra-Balsells, R. (2001) . Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry, 15(23), 2354-2373.http://dx.doi.org/10.1002/rcm.514
---------- CHICAGO ----------
Nonami, H., Wu, F., Thummel, R.P., Fukuyama, Y., Yamaoka, H., Erra-Balsells, R. "Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry" . Rapid Communications in Mass Spectrometry 15, no. 23 (2001) : 2354-2373.http://dx.doi.org/10.1002/rcm.514
---------- MLA ----------
Nonami, H., Wu, F., Thummel, R.P., Fukuyama, Y., Yamaoka, H., Erra-Balsells, R. "Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry" . Rapid Communications in Mass Spectrometry, vol. 15, no. 23, 2001, pp. 2354-2373.http://dx.doi.org/10.1002/rcm.514
---------- VANCOUVER ----------
Nonami, H., Wu, F., Thummel, R.P., Fukuyama, Y., Yamaoka, H., Erra-Balsells, R. Evaluation of pyridoindoles, pyridylindoles and pyridylpyridoindoles as matrices for ultraviolet matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2001;15(23):2354-2373.http://dx.doi.org/10.1002/rcm.514
