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Abstract:

Crude extracts obtained from leaves of Cedrela tubiflora (CT) (Meliaceae family) show antiviral and virucidal effects against several viruses. Herpes simplex, pseudorabies and vesicular stomatitis viruses were extremely susceptible and a reduction of 3–5 log in infectivity occurred after 15 min of direct incubation with the plant extract. By contrast, poliovirus and the Tacaribe arenavirus are inhibited intracellularly. The inhibitory action is dose dependent and no cytotoxic effects were detected on Vero cells after 2 days of CT treatment. Copyright © 1991 John Wiley & Sons, Ltd.

Registro:

Documento: Artículo
Título:Virucidal activity in aqueous extracts obtained from Cedrela tubiflora leaves
Autor:Cordoba, M.A.; Coto, C.E.; Damonte, E.B.
Filiación:Laboratorio de Virología, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, Piso 4, Buenos Aires, 1428, Argentina
Palabras clave:Cedrela tubiflora; herpes‐virus; Meliaceae; plant antiviral; vesicular stomatitis virus; virucidal activity; cedrela tubiflora extract; plant extract; unclassified drug; animal cell; antiviral activity; article; controlled study; cytotoxicity; herpes simplex virus 1; nonhuman; plant leaf; poliomyelitis virus; pseudorabies herpetovirus; vero cell; vesicular stomatitis virus; Animalia; Arenavirus; Cedrela; Cedrela tubiflora; Herpes; herpetovirus; Human herpesvirus 1; Meliaceae; Poliovirus; Suid herpesvirus 1; Vesicular stomatitis virus
Año:1991
Volumen:5
Número:6
Página de inicio:250
Página de fin:253
DOI: http://dx.doi.org/10.1002/ptr.2650050604
Título revista:Phytotherapy Research
Título revista abreviado:Phytother. Res.
ISSN:0951418X
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v5_n6_p250_Cordoba

Referencias:

  • Andrei, G.M., Coto, C.E., De Torres, R.A., Ensayos de citotoxicidad y actividad antiviral de extractos crudos y semipurificados de hojas verdes de Melia azedarach L (1985) Rev. Arg. Microbiol., 17, pp. 187-194
  • Andrei, G.M., Damonte, E.B., de Torres, R.A., Coto, C.E., Induction of a refractory state to viral infection in mammalian cells by a plant inhibitor isolated from leaves of Melia azedarach L (1988) Antiviral Res., 9, pp. 221-231
  • Andrei, G.M., Lampuri, J.S., Coto, C.E., De Torres, R.A., An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice (1986) Experientia, 42, pp. 843-845
  • Bradford, M.M., A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding (1976) Anal. Biochem., 72, pp. 248-254
  • Van den Berghe, D.A., Vlietinck, A.J., Van Hoof, L., Plant products as potential antiviral agents (1986) Bull. Inst. Pasteur, 84, pp. 101-147
  • Wachsman, M.B., Coto, C.E., Martino, V., Search for antiviral activity in higher plant extracts (1988) Fitoterapia, 59, pp. 422-424
  • Wachsman, M.B., Martino, V., Gutking, G.O., Cussio, J.D., Coto, C.E., De Torres, R.A., Antiviral activity of Melia azedarach L. plant extracts (1982) Fitoterapia, 53, pp. 167-170

Citas:

---------- APA ----------
Cordoba, M.A., Coto, C.E. & Damonte, E.B. (1991) . Virucidal activity in aqueous extracts obtained from Cedrela tubiflora leaves. Phytotherapy Research, 5(6), 250-253.
http://dx.doi.org/10.1002/ptr.2650050604
---------- CHICAGO ----------
Cordoba, M.A., Coto, C.E., Damonte, E.B. "Virucidal activity in aqueous extracts obtained from Cedrela tubiflora leaves" . Phytotherapy Research 5, no. 6 (1991) : 250-253.
http://dx.doi.org/10.1002/ptr.2650050604
---------- MLA ----------
Cordoba, M.A., Coto, C.E., Damonte, E.B. "Virucidal activity in aqueous extracts obtained from Cedrela tubiflora leaves" . Phytotherapy Research, vol. 5, no. 6, 1991, pp. 250-253.
http://dx.doi.org/10.1002/ptr.2650050604
---------- VANCOUVER ----------
Cordoba, M.A., Coto, C.E., Damonte, E.B. Virucidal activity in aqueous extracts obtained from Cedrela tubiflora leaves. Phytother. Res. 1991;5(6):250-253.
http://dx.doi.org/10.1002/ptr.2650050604