Abstract:
Crude extracts obtained from leaves of Cedrela tubiflora (CT) (Meliaceae family) show antiviral and virucidal effects against several viruses. Herpes simplex, pseudorabies and vesicular stomatitis viruses were extremely susceptible and a reduction of 3–5 log in infectivity occurred after 15 min of direct incubation with the plant extract. By contrast, poliovirus and the Tacaribe arenavirus are inhibited intracellularly. The inhibitory action is dose dependent and no cytotoxic effects were detected on Vero cells after 2 days of CT treatment. Copyright © 1991 John Wiley & Sons, Ltd.
Registro:
Documento: |
Artículo
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Título: | Virucidal activity in aqueous extracts obtained from Cedrela tubiflora leaves |
Autor: | Cordoba, M.A.; Coto, C.E.; Damonte, E.B. |
Filiación: | Laboratorio de Virología, Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón 2, Piso 4, Buenos Aires, 1428, Argentina
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Palabras clave: | Cedrela tubiflora; herpes‐virus; Meliaceae; plant antiviral; vesicular stomatitis virus; virucidal activity; cedrela tubiflora extract; plant extract; unclassified drug; animal cell; antiviral activity; article; controlled study; cytotoxicity; herpes simplex virus 1; nonhuman; plant leaf; poliomyelitis virus; pseudorabies herpetovirus; vero cell; vesicular stomatitis virus; Animalia; Arenavirus; Cedrela; Cedrela tubiflora; Herpes; herpetovirus; Human herpesvirus 1; Meliaceae; Poliovirus; Suid herpesvirus 1; Vesicular stomatitis virus |
Año: | 1991
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Volumen: | 5
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Número: | 6
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Página de inicio: | 250
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Página de fin: | 253
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DOI: |
http://dx.doi.org/10.1002/ptr.2650050604 |
Título revista: | Phytotherapy Research
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Título revista abreviado: | Phytother. Res.
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ISSN: | 0951418X
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v5_n6_p250_Cordoba |
Referencias:
- Andrei, G.M., Coto, C.E., De Torres, R.A., Ensayos de citotoxicidad y actividad antiviral de extractos crudos y semipurificados de hojas verdes de Melia azedarach L (1985) Rev. Arg. Microbiol., 17, pp. 187-194
- Andrei, G.M., Damonte, E.B., de Torres, R.A., Coto, C.E., Induction of a refractory state to viral infection in mammalian cells by a plant inhibitor isolated from leaves of Melia azedarach L (1988) Antiviral Res., 9, pp. 221-231
- Andrei, G.M., Lampuri, J.S., Coto, C.E., De Torres, R.A., An antiviral factor from Melia azedarach L. prevents Tacaribe virus encephalitis in mice (1986) Experientia, 42, pp. 843-845
- Bradford, M.M., A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding (1976) Anal. Biochem., 72, pp. 248-254
- Van den Berghe, D.A., Vlietinck, A.J., Van Hoof, L., Plant products as potential antiviral agents (1986) Bull. Inst. Pasteur, 84, pp. 101-147
- Wachsman, M.B., Coto, C.E., Martino, V., Search for antiviral activity in higher plant extracts (1988) Fitoterapia, 59, pp. 422-424
- Wachsman, M.B., Martino, V., Gutking, G.O., Cussio, J.D., Coto, C.E., De Torres, R.A., Antiviral activity of Melia azedarach L. plant extracts (1982) Fitoterapia, 53, pp. 167-170
Citas:
---------- APA ----------
Cordoba, M.A., Coto, C.E. & Damonte, E.B.
(1991)
. Virucidal activity in aqueous extracts obtained from Cedrela tubiflora leaves. Phytotherapy Research, 5(6), 250-253.
http://dx.doi.org/10.1002/ptr.2650050604---------- CHICAGO ----------
Cordoba, M.A., Coto, C.E., Damonte, E.B.
"Virucidal activity in aqueous extracts obtained from Cedrela tubiflora leaves"
. Phytotherapy Research 5, no. 6
(1991) : 250-253.
http://dx.doi.org/10.1002/ptr.2650050604---------- MLA ----------
Cordoba, M.A., Coto, C.E., Damonte, E.B.
"Virucidal activity in aqueous extracts obtained from Cedrela tubiflora leaves"
. Phytotherapy Research, vol. 5, no. 6, 1991, pp. 250-253.
http://dx.doi.org/10.1002/ptr.2650050604---------- VANCOUVER ----------
Cordoba, M.A., Coto, C.E., Damonte, E.B. Virucidal activity in aqueous extracts obtained from Cedrela tubiflora leaves. Phytother. Res. 1991;5(6):250-253.
http://dx.doi.org/10.1002/ptr.2650050604