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Abstract:

Eugenol (4-allyl-1-hydroxy-2-methoxybenzene) was tested for antiviral activity against HSV-1 and HSV-2 viruses. In vitro, it was found that the replication of these viruses was inhibited in the presence of this compound. Inhibitory concentration 50% values for the anti-HSV effects of eugenol were 25.6 μg/mL and 16.2 μg/mL for HSV-1 and HSV-2 respectively, 250 μg/mL being the maximum dose at which cytotoxicity was tested. Eugenol was virucidal and showed no cytotoxicity at the concentrations tested. Eugenol-acyclovir combinations synergistically inhibited herpesvirus replication in vitro. Topical application of eugenol delayed the development of herpesvirus induced keratitis in the mouse model. (C) 2000 John Wiley and Sons, Ltd.

Registro:

Documento: Artículo
Título:In vitro and in vivo activity of eugenol on human herpesvirus
Autor:Benencia, F.; Courrges, M.C.
Filiación:Departamento Qumica Biolgica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Centro de Patologa Experimental, Facultad de Medicina, Universidad de Buenos Aires, Uriburu 950. 5to. Piso, 1115 Buenos Aires, Argentina
Laboratorio de Inmunoqumica, Dpto. Qumica Biolgica, Ciudad Universitaria, 1428 Buenos Aires, Argentina
Palabras clave:Acyclovir; Antiviral activity; Eugenol; Herpesvirus; Herpetic keratitis; aciclovir; eugenol; animal cell; animal experiment; animal model; antiviral activity; article; controlled study; cytotoxicity; drug mixture; drug potentiation; herpes simplex keratitis; Herpes simplex virus 1; Herpes simplex virus 2; Herpes virus infection; IC 50; mouse; nonhuman; phytotherapy; Vero cell; virus replication; Acyclovir; Animals; Antiviral Agents; Cercopithecus aethiops; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Eugenol; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Vero Cells; Animalia; Herpes; Herpesviridae; Human herpesvirus 1; Human herpesvirus 2
Año:2000
Volumen:14
Número:7
Página de inicio:495
Página de fin:500
DOI: http://dx.doi.org/10.1002/1099-1573(200011)14:7<495::AID-PTR650>3.0.CO;2-8
Título revista:Phytotherapy Research
Título revista abreviado:Phytother. Res.
ISSN:0951418X
CODEN:PHYRE
CAS:Acyclovir, 59277-89-3; Antiviral Agents; Drug Combinations; Eugenol, 97-53-0
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v14_n7_p495_Benencia

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Citas:

---------- APA ----------
Benencia, F. & Courrges, M.C. (2000) . In vitro and in vivo activity of eugenol on human herpesvirus. Phytotherapy Research, 14(7), 495-500.
http://dx.doi.org/10.1002/1099-1573(200011)14:7<495::AID-PTR650>3.0.CO;2-8
---------- CHICAGO ----------
Benencia, F., Courrges, M.C. "In vitro and in vivo activity of eugenol on human herpesvirus" . Phytotherapy Research 14, no. 7 (2000) : 495-500.
http://dx.doi.org/10.1002/1099-1573(200011)14:7<495::AID-PTR650>3.0.CO;2-8
---------- MLA ----------
Benencia, F., Courrges, M.C. "In vitro and in vivo activity of eugenol on human herpesvirus" . Phytotherapy Research, vol. 14, no. 7, 2000, pp. 495-500.
http://dx.doi.org/10.1002/1099-1573(200011)14:7<495::AID-PTR650>3.0.CO;2-8
---------- VANCOUVER ----------
Benencia, F., Courrges, M.C. In vitro and in vivo activity of eugenol on human herpesvirus. Phytother. Res. 2000;14(7):495-500.
http://dx.doi.org/10.1002/1099-1573(200011)14:7<495::AID-PTR650>3.0.CO;2-8