Artículo
Pujol, C.A.; Errea, M.I.; Matulewicz, M.C.; Damonte, E.B. "Antiherpetic activity of s1, an algal derived sulphated galactan" (1997) Phytotherapy Research. 11(8):410-413
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Abstract:
The sulphated galactan S1 isolated from the red seaweed Pterocladia capillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 μg/mL that were in excess of the IC 50 values (range from 3.2 to 12.0 μg/mL for the different herpesviruses assayed). The antiherpetic action of S1 was independent of the host cell and the antiviral assay. The kinetics of infectious virus adsorption to the host cell was highly inhibited in the presence of S1 whereas the subsequent stage of virus penetration was not affected. The binding of radiolabelled HSV-1 particles was inhibited in a dose dependent manner confirming that the mode of action of S1 could be attributable to an inhibition of initial virus attachment to the host cell. © 1996 by John Wiley & Sons, Ltd.
Registro:
| Documento: | Artículo |
| Título: | Antiherpetic activity of s1, an algal derived sulphated galactan |
| Autor: | Pujol, C.A.; Errea, M.I.; Matulewicz, M.C.; Damonte, E.B. |
| Filiación: | Laboratorio de Virologia, Departamento de Química Biológica, Argentina Departamento de Química Or̀gánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, 1428 Buenos Aires, Argentina |
| Palabras clave: | Herpes simplex virus; Natural antiviral; Pterocladia capillacea; Red seaweed; Sulphated polysaccharide; Virus attachment |
| Año: | 1997 |
| Volumen: | 11 |
| Número: | 8 |
| Página de inicio: | 410 |
| Página de fin: | 413 |
| Título revista: | Phytotherapy Research |
| Título revista abreviado: | Phytother. Res. |
| ISSN: | 0951418X |
| CODEN: | PHYRE |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v11_n8_p410_Pujol |
Referencias:
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- Bourgougnon, N., Lahaye, M., Chermann, J.C., Kornprobst, J.M., Composition and antiviral activities of a sulphated polysaccharide from Schizymenia dubyi (Rodophyta, Gigartinales) (1993) Bioorg. Med. Chem. Lett., 3, pp. 1141-1146
- Damonte, E., Neyts, J., Pujol, C.A., Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata (1994) Biochem. Pharmacol., 47, pp. 2187-2192
- Englund, J.A., Zimmerman, M.E., Swierkosz, E.U., Goodman, J.L., School, D.R., Balfour Jr., H.H., Herpes simplex virus resistant to acyclovir: A study in a tertiary care center (1990) Ann. Intern. Med., 112, pp. 416-422
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- Herold, B.C., Wudunn, D., Soltys, N., Spear, P.G., Glycoprotein C of herpes simplex virus type 1 plays a principal role in the adsorption of virus to cells and in infectivity (1991) J. Virol., 65, pp. 1090-1098
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- Nakashima, H., Kido, Y., Kobashayi, N., Motoki, Y., Neushul, M., Yamamoto, N., Purification and characterization of an avian myeloblastosis and human immunodeficiency virus reverse transcriptase inhibitor sulphated polysaccharide extracted from sea algae (1987) Antimicrob. Agents Chemother., 31, pp. 1524-1528
- Reefschlager, J., Herrmann, G., Barwolff, D., Schwartz, B., Cech, D., Langen, P., Antiherpes activity of (E)-5-(2-bromovinyl)- And 5-vinyl-1-β-D-arabinofuranosyluracil and some other 5-substituted uracil arabinosyl nucleosides in two different cell lines (1983) Antiviral Res., 3, pp. 175-187
- Suzutani, T., Machida, H., Sakuma, T., Efficacies of antiherpesvirus nucleosides against two strains of herpes simplex virus type 1 in Vero and human embryo lung fibroblast cells (1988) Antimicrob. Agents Chemother., 32, pp. 1046-1052
- Whitley, R.J., Gnann, J.W., Acyclovir: A decade later (1992) N. Eng. J. Med., 327, pp. 782-789
- Whitley, R.J., Gnann, J.W., The epidemiology and clinical manifestations of herpes simplex virus infections (1993) The Human Herpesviruses, pp. 69-105. , ed. by B. Roizman, R. J. Whitley and C. Lopez, Raven Press, New York
- Witorouw, M., Este, J.A., Mateu, M.Q., Activity of a sulphated polysaccharide extracted from the red seaweed Aghardiella tenera against human immunodeficiency virus and other enveloped viruses (1994) Antiviral Chem. Chemother., 5, pp. 297-303
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Citas:
---------- APA ----------
Pujol, C.A., Errea, M.I., Matulewicz, M.C. & Damonte, E.B. (1997) . Antiherpetic activity of s1, an algal derived sulphated galactan. Phytotherapy Research, 11(8), 410-413.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v11_n8_p410_Pujol [ ]
---------- CHICAGO ----------
Pujol, C.A., Errea, M.I., Matulewicz, M.C., Damonte, E.B. "Antiherpetic activity of s1, an algal derived sulphated galactan" . Phytotherapy Research 11, no. 8 (1997) : 410-413.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v11_n8_p410_Pujol [ ]
---------- MLA ----------
Pujol, C.A., Errea, M.I., Matulewicz, M.C., Damonte, E.B. "Antiherpetic activity of s1, an algal derived sulphated galactan" . Phytotherapy Research, vol. 11, no. 8, 1997, pp. 410-413.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v11_n8_p410_Pujol [ ]
---------- VANCOUVER ----------
Pujol, C.A., Errea, M.I., Matulewicz, M.C., Damonte, E.B. Antiherpetic activity of s1, an algal derived sulphated galactan. Phytother. Res. 1997;11(8):410-413.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0951418X_v11_n8_p410_Pujol [ ]
