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The sulphated galactan S1 isolated from the red seaweed Pterocladia capillacea proved to be a selective antiviral compound against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), human cytomegalovirus and pseudorabies virus. No cytotoxicity was observed with S1 at concentrations about 500 μg/mL that were in excess of the IC 50 values (range from 3.2 to 12.0 μg/mL for the different herpesviruses assayed). The antiherpetic action of S1 was independent of the host cell and the antiviral assay. The kinetics of infectious virus adsorption to the host cell was highly inhibited in the presence of S1 whereas the subsequent stage of virus penetration was not affected. The binding of radiolabelled HSV-1 particles was inhibited in a dose dependent manner confirming that the mode of action of S1 could be attributable to an inhibition of initial virus attachment to the host cell.


Documento: Artículo
Título:Antiherpetic activity of S1, an algal derived sulphated galactan
Autor:Pujol, C.A.; Errea, M.I.; Matulewicz, M.C.; Damonte, E.B.
Filiación:Laboratorio de Virologia, Departamento de Química Biológica, Ciudad Universitaria, Pabellón 2, 1428 Buenos Aires, Argentina
Departamento de Química Or̀gánica, Facultad de Ciencias Exactas y Naturales, Ciudad Universitaria, Pabellón 2, 1428 Buenos Aires, Argentina
Palabras clave:Herpes simplex virus; Natural antiviral; Pterocladia capillacea; Red seaweed; Sulphated polysaccharide; Virus attachment; antivirus agent; galactane sulfate; plant extract; unclassified drug; animal cell; antiviral activity; article; concentration response; controlled study; cytotoxicity; drug mechanism; herpes simplex virus 1; herpes simplex virus 2; herpes virus; host cell; human; human cell; human cytomegalovirus; nonhuman; pseudorabies herpetovirus; red alga; virus adsorption; algae; Animalia; Herpes; Herpesviridae; herpetovirus; Human herpesvirus 1; Human herpesvirus 2; Human herpesvirus 5; Pterocladia; Pterocladiella capillacea; Rhodophyta; Simplexvirus; Suid herpesvirus 1
Página de inicio:410
Página de fin:413
Título revista:Phytotherapy Research
Título revista abreviado:PHYTOTHER. RES.


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---------- APA ----------
Pujol, C.A., Errea, M.I., Matulewicz, M.C. & Damonte, E.B. (1996) . Antiherpetic activity of S1, an algal derived sulphated galactan. Phytotherapy Research, 10(5), 410-413.<410::AID-PTR875>3.0.CO;2-K
---------- CHICAGO ----------
Pujol, C.A., Errea, M.I., Matulewicz, M.C., Damonte, E.B. "Antiherpetic activity of S1, an algal derived sulphated galactan" . Phytotherapy Research 10, no. 5 (1996) : 410-413.<410::AID-PTR875>3.0.CO;2-K
---------- MLA ----------
Pujol, C.A., Errea, M.I., Matulewicz, M.C., Damonte, E.B. "Antiherpetic activity of S1, an algal derived sulphated galactan" . Phytotherapy Research, vol. 10, no. 5, 1996, pp. 410-413.<410::AID-PTR875>3.0.CO;2-K
---------- VANCOUVER ----------
Pujol, C.A., Errea, M.I., Matulewicz, M.C., Damonte, E.B. Antiherpetic activity of S1, an algal derived sulphated galactan. PHYTOTHER. RES. 1996;10(5):410-413.<410::AID-PTR875>3.0.CO;2-K