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Vilariño-García, T.; Pérez-Pérez, A.; Dietrich, V.; Guadix, P.; Dueñas, J.L.; Varone, C.L.; Damiano, A.E.; Sánchez-Margalet, V. "Leptin upregulates aquaporin 9 expression in human placenta in vitro" (2018) Gynecological Endocrinology. 34(2):175-177
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Abstract:

Aquaporins are integral membrane proteins that have permeability functions in many tissues. Aquaporin 9 may transport not only water but also small molecules, such as glycerol, monocarboxylates, purines and pyrimidines. Aquaporin 9 is expressed in syncytiotrophoblast of human term placenta, and it may contribute to the embryonic/fetal growth and survival. We have previously found that Aquaporin 9 expression levels seem to be increased in placenta from gestational diabetes. Since leptin plasma levels and leptin expression are increased in placenta from gestational diabetes, we aimed to study the possible role of leptin on Aquaporin 9 expression in human placenta in vitro. The present work shows that leptin produces a dose-dependent increase of Aquaporin 9 expression, resulting in an increase in Aquaporin-9 protein in human trophoblast explants. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Registro:

Documento: Artículo
Título:Leptin upregulates aquaporin 9 expression in human placenta in vitro
Autor:Vilariño-García, T.; Pérez-Pérez, A.; Dietrich, V.; Guadix, P.; Dueñas, J.L.; Varone, C.L.; Damiano, A.E.; Sánchez-Margalet, V.
Filiación:Department of Clinical Biochemistry, Virgen Macarena University Hospital, Medical School, University of Seville, Spain
Department of Biological Sciences, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
Obstetrics and Gynecology Department, Virgen Macarena University Hospital, Medical School, University of Seville, Spain
Department of Biological Chemistry, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina
Palabras clave:AQP9; GDM; Leptin; pregnancy; transporter; Trophoblastic cells; aquaporin 9; beta tubulin; leptin; messenger RNA; AQP9 protein, human; aquaporin; leptin; Article; controlled study; female; gene expression; human; human cell; human tissue; in vitro study; placenta; priority journal; protein expression; protein function; regulatory mechanism; transcription regulation; trophoblast; upregulation; adult; cesarean section; cytology; gene expression regulation; genetics; glycosylation; immunoblotting; metabolism; osmolarity; placenta; pregnancy; protein processing; reproducibility; reverse transcription polymerase chain reaction; term birth; tissue culture technique; upregulation; Adult; Aquaporins; Cesarean Section; Female; Gene Expression Regulation, Developmental; Glycosylation; Humans; Immunoblotting; Leptin; Osmolar Concentration; Placenta; Pregnancy; Protein Processing, Post-Translational; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Term Birth; Tissue Culture Techniques; Trophoblasts; Up-Regulation
Año:2018
Volumen:34
Número:2
Página de inicio:175
Página de fin:177
DOI: http://dx.doi.org/10.1080/09513590.2017.1380184
Título revista:Gynecological Endocrinology
Título revista abreviado:Gynecol. Endocrinol.
ISSN:09513590
CODEN:GYENE
CAS:beta tubulin, 87090-36-6; aquaporin, 215587-75-0; AQP9 protein, human; Aquaporins; Leptin
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09513590_v34_n2_p175_VilarinoGarcia

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Citas:

---------- APA ----------
Vilariño-García, T., Pérez-Pérez, A., Dietrich, V., Guadix, P., Dueñas, J.L., Varone, C.L., Damiano, A.E.,..., Sánchez-Margalet, V. (2018) . Leptin upregulates aquaporin 9 expression in human placenta in vitro. Gynecological Endocrinology, 34(2), 175-177.
http://dx.doi.org/10.1080/09513590.2017.1380184
---------- CHICAGO ----------
Vilariño-García, T., Pérez-Pérez, A., Dietrich, V., Guadix, P., Dueñas, J.L., Varone, C.L., et al. "Leptin upregulates aquaporin 9 expression in human placenta in vitro" . Gynecological Endocrinology 34, no. 2 (2018) : 175-177.
http://dx.doi.org/10.1080/09513590.2017.1380184
---------- MLA ----------
Vilariño-García, T., Pérez-Pérez, A., Dietrich, V., Guadix, P., Dueñas, J.L., Varone, C.L., et al. "Leptin upregulates aquaporin 9 expression in human placenta in vitro" . Gynecological Endocrinology, vol. 34, no. 2, 2018, pp. 175-177.
http://dx.doi.org/10.1080/09513590.2017.1380184
---------- VANCOUVER ----------
Vilariño-García, T., Pérez-Pérez, A., Dietrich, V., Guadix, P., Dueñas, J.L., Varone, C.L., et al. Leptin upregulates aquaporin 9 expression in human placenta in vitro. Gynecol. Endocrinol. 2018;34(2):175-177.
http://dx.doi.org/10.1080/09513590.2017.1380184