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Abstract:

The present study focused on interactions between signaling pathways activated by progestins and by type I and II receptor tyrosine kinases (RTKs) in mammary tumors. An experimental model in which the synthetic progestin medroxyprogesterone acetate (MPA) induced mammary adenocarcinomas in Balb/c mice was used. MPA-stimulated proliferation, both in vivo and in vitro, of progestin-dependent tumors induced up-regulation of ErbB-2 protein levels and tyrosine phosphorylation of this receptor. Combinations of antisense oligodeoxynueleotides (ASODNs) directed to ErbB-2 mRNA with ASODNs directed to the insulin-like growth factor-I receptor (IGF-IR) were used to study the effect of the simultaneous block of these receptors on the MPA-induced proliferation of epithelial cells from the progestin-dependent C4HD line. Neither synergistic nor additive effects on the inhibition of MPA-induced proliferation of C4HD cells were observed as a result of the combination of these ASODNs. Suppression of IGF-IR expression by ASODNs resulted in complete abrogation of MPA-induced phosphorylation of ErbB-2 in C4HD cells, whereas blockage of ErbB-2 did not affect IGF-IR phosphorylation. These results show the existence of a hierarchical interaction between IGF-IR and ErbB-2, by means of which IGF-IR directs ErbB-2 phosphorylation. We demonstrated, for the first time, that this hierarchical interaction involves physical association of both receptors, resulting in the formation of a heteromeric complex. Furthermore, confocal laser microscopy experiments demonstrated that MPA was able to induce co-localization of ErbB-2 and IGF-IR. This hetero-oligomer was also found in MCF-7 human breast cancer cells in which association of IGF-IR and ErbB-2 was induced by heregulin and IGF-I.

Registro:

Documento: Artículo
Título:Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insalia-like growth factor receptor in mammary tumor cells
Autor:Balãá, M.E.; Labriola, L.; Salatino, M.; Movsichoff, F.; Peters, G.; Charreau, E.H.; Elizalde, P.V.
Filiación:Instituto de Biología Y Medicina Experimental (IBYME), Obligado 2490, Buenos Aires 1428, Argentina
Facultad de Ciencias Exactas Y Naturales, Universidad de Buenos Aires, Buenos Aires 1428, Argentina
Palabras clave:ErbB receptors; Mammary tumorigenesis; Progestin; Type I insulin-like growth factor receptor; antisense oligodeoxynucleotide; gestagen; medroxyprogesterone acetate; messenger RNA; neu differentiation factor; oligomer; protein tyrosine kinase; somatomedin C receptor; animal cell; animal experiment; animal model; animal tissue; article; breast carcinogenesis; breast epithelium; breast tumor; cell proliferation; complex formation; confocal laser microscopy; controlled study; female; gene activation; mouse; nonhuman; oncogene neu; priority journal; protein localization; protein phosphorylation; protein protein interaction; signal transduction; Animals; Enzyme Activation; Epithelial Cells; Female; Macromolecular Substances; Mammary Neoplasms, Experimental; Medroxyprogesterone 17-Acetate; Mice; Mice, Inbred BALB C; Oligodeoxyribonucleotides, Antisense; Phosphorylation; Progesterone Congeners; Receptor Cross-Talk; Receptor, erbB-2; Receptor, IGF Type 1; Signal Transduction; Tumor Cells, Cultured; Tyrosine; Animalia; Mink cell focus-forming virus
Año:2001
Volumen:20
Número:1
Página de inicio:34
Página de fin:47
DOI: http://dx.doi.org/10.1038/sj.onc.1204050
Título revista:Oncogene
Título revista abreviado:Oncogene
ISSN:09509232
CODEN:ONCNE
CAS:Macromolecular Substances; Medroxyprogesterone 17-Acetate, 71-58-9; Oligodeoxyribonucleotides, Antisense; Progesterone Congeners; Receptor, erbB-2, EC 2.7.1.112; Receptor, IGF Type 1, EC 2.7.1.112; Tyrosine, 55520-40-6
PDF:https://bibliotecadigital.exactas.uba.ar/download/paper/paper_09509232_v20_n1_p34_Balaa.pdf
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09509232_v20_n1_p34_Balaa

Referencias:

  • Backer, J.M., Myers, M.G., Sun, X.J., Chen, D.J., Schoelson, S.E., Mivalpeix, M., White, M.F., (1993) J. Biol. Chem., 268, pp. 8204-8212
  • Balañá, M.E., Lupu, R., Labriola, L., Charreau, E.H., Elizalde, P.V., (1999) Oncogene, 18, pp. 6370-6379
  • Baserga, R., (1995) Cancer Res., 55, pp. 249-252
  • Braunsberg, H., Coldham, N.G., Learke, R.E., Cowan, S.K., Wong, W., (1987) Eur. J. Cancer Clin. Oncol., 23, pp. 563-571
  • Carraway, K.L., Cantley, L.C., (1994) Cell, 78, pp. 5-8
  • Clarke, C.L., Sutherland, R.L., (1990) Endocr. Rev., 11, pp. 266-302
  • Cohen, G.B., Ren, R., Baltimore, D., (1995) Cell, 80, pp. 237-248
  • Colomer, R., Lupu, R., Bacus, S.S., Gelmann, E.P., (1994) Br. J. Cancer., 70, pp. 819-825
  • Coppola, D., Ferber, A., Masahiko, M., Sell, C., D'Ambrosio, C., Rubin, R., Baserga, R., (1994) Mol. Cell. Biol., 14, pp. 4588-4595
  • Dati, C., Antoniotti, S., Taberna, D., Perroteau, I., De Bortoli, M., (1990) Oncogene, 5, pp. 1001-1006
  • De Bortoli, M., Dati, C., (1997) J. Mam. Gland. Biol. Neoplasia, 2, pp. 175-185
  • Dickson, R., Lippman, M.E., (1995) Endocrin. Rev., 16, pp. 559-589
  • Dran, G., Luthy, I.A., Molinolo, A.A., Montecchia, F., Charreau, E.H., Dosne Pasqualini, C., Lanari, C., (1995) Breast Cancer Res. Treat., 35, pp. 173-186
  • Egan, S.E., Weinberg, R.A., (1993) Nature, 365, pp. 781-783
  • Elizalde, P.V., Lanari, C., Bussman, L., Kordon, E., Guerra, F., Savin, M., Charreau, E.H., (1990) J. Exp. Clin. Cancer Res., 9, pp. 193-203
  • Elizalde, P.V., Lanari, C., Molinolo, A.A., Guerra, F.K., Balañá, M.E., Simian, M., Iribarren, A., Charreau, E.H., (1998) J. Steroid. Biochem. Molec. Biol., 67, pp. 305-317
  • Fedi, P., Pierce, J., Di Fiore, P.P., Kraus, M., (1994) Mol. Cell. Biol., 14, pp. 492-500
  • Graus-Porta, D., Beerli, R.R., Daly, J.M., Hynes, N.E., (1997) EMBO J., 16, pp. 1647-1655
  • Groshong, S.D., Owen, G.I., Grimison, B., Schauer, I.E., Todd, M.C., Langan, T.A., Sclafani, R.A., Horwitz, K.B., (1997) Mol. Endocrinol., 11, pp. 1593-1607
  • Grunt, T.W., Saceda, M., Martin, M.B., Lupu, R., Dittrich, E., Krupitza, G., Harant, H., Dittrich, C., (1995) Int. J. Cancer., 63, pp. 560-567
  • Holmes, W.E., Sliwkowski, M.X., Akita, R.W., Henzel, W.J., Lee, J., Park, J.W., Yansura, D., Vandlen, R.L., (1992) Science, 256, pp. 1205-1210
  • Kavanaugh, W.M., Williams, L.T., (1994) Science, 266, pp. 1862-1865
  • Kiss, R., Paridaens, R.J., Heuson, J.C., Danguy, A.J., (1986) J. Natl. Cancer Inst., 77, pp. 173-178
  • Kordon, E.C., Guerra, F.K., Molinolo, A.A., Elizalde, P.V., Charreau, E.H., Dosne Pasqualini, C.D., Montecchia, F., Lanari, C., (1994) Int. J. Cancer., 59, pp. 196-203
  • Kraus, M.H., Issing, W., Miki, T., Popescu, N.C., Aaronson, S.A., (1989) Proc. Natl. Acad. Sci. USA, 86, pp. 9193-9197
  • Lanari, C., Kordon, E., Molinolo, A.A., Dosne Pasqualini, C., Charreau, E.H., (1989) Int. J. Cancer., 43, pp. 845-850
  • Lange, C.A., Richer, J.K., Shen, T., Horwitz, K., (1998) J. Biol. Chem., 273, pp. 31308-31316
  • LeRoith, D., Werner, H., Beitner-Johnson, D., Roberts, C.T., (1995) Endocr. Rev., 16, pp. 143-163
  • Lewis, G.D., Lofgren, J.A., McMurtrey, A.E., Nuijens, A., Fendly, B.M., Bauer, K.D., Sliwkowski, M.X., (1996) Cancer Res., 56, pp. 1457-1465
  • Lowenstein, E.J., Daly, R.J., Batzer, A.G., Li, W., Margolis, B., Lammers, R., Ullrich, A., Schlessinger, J., (1992) Cell, 70, pp. 431-442
  • Lupu, R., Lippman, M.E., (1993) Breast Cancer Res. Treat., 27, pp. 83-93
  • Manni, A., Badger, B., Wright, C., Ahmed, J.R., Demers, L.M., (1987) Cancer Res., 47, pp. 3066-3071
  • Migliaccio, A., Di Domenico, M., Castoria, G., De Falco, A., Bontempo, P., Nola, E., Auricchio, F., (1996) EMBO J., 15, pp. 1292-1300
  • Migliaccio, A., Piccolo, D., Castoria, G., Di Domenico, M., Bilancio, A., Lombardi, M., Gong, W., Auricchio, F., (1998) EMBO J., 17, pp. 2008-2018
  • Ming, X.F., Burgering, B.M.T., Wennstrom, S., Claeson-Welsh, L., Heldin, C., Bos, J.L., Kozma, S.C., Thomas, G., (1994) Nature, 371, pp. 426-429
  • Modiano, J.F., Kokai, Y., Weiner, D.B., Pykett, M.J., Nowell, P.C., Lyttle, C.R., (1991) J. Cell. Biochem., 45, pp. 196-206
  • Molinolo, A.A., Lanari, C., Charreau, E.H., San Juan, N., Dosne Pasqualini, C., (1987) J. Natl. Cancer Inst., 79, pp. 1341-1350
  • Murphy, L.J., Surtherland, R.L., Stead, B., Murphy, L.C., Lazarus, L., (1986) Cancer Res., 46, pp. 728-734
  • Murphy, L.C., Murphy, L.J., Dubik, D., Bell, G.I., Shiu, R.P., (1988) Cancer Res., 48, pp. 4555-4560
  • Pelicci, G., Lanfrancone, N., Grignani, F., McGlade, J., Cavallo, F., Forni, G., Nicoletti, I., Pelicci, P.G., (1992) Cell, 70, pp. 93-104
  • Pinkas-Kramaski, R., Alroy, I., Yarden, Y., (1997) J. Mam. Gland. Biol. Neoplasia, 2, pp. 97-107
  • Plowman, G.D., Whitney, G.S., Neubauer, M.G., Green, J.M., McDonald, V.L., Todaro, G.J., Shoyab, M., (1990) Proc. Natl. Acad. Sci. USA, 87, pp. 4905-4909
  • Plowman, G.D., Culouscou, J.-M., Whitney, G.S., Green, J.M., Carlton, G.W., Foy, L., Neubauer, M.G., Shoyab, M., (1993) Proc. Natl. Acad. Sci. USA, 90, pp. 1746-1750
  • Ram, T.G., Kokeny, K.E., Dilts, C.A., Ethier, S.P., (1995) J. Cell. Physiol., 163, pp. 589-596
  • Ram, T.G., Dilts, C.A., Dziubinski, M.L., Pierce, L.J., Ethier, S.P., (1996) Mol. Carcinog., 15, pp. 227-238
  • Read, L.D., Keith, D., Slamon, D.J., Katznellenbogen, B.S., (1990) Cancer Res., 50, pp. 3947-3951
  • Richer, J.K., Lange, C., Manning, N.G., Owen, G., Powell, R., Horwitz, K.B., (1998) J. Biol. Chem., 273, pp. 31317-31326
  • Riese II, D.J., Stern, D.F., (1998) Bioessays, 20, pp. 41-48
  • Sarup, J.C., Rao, K.V., Fox, C.F., (1988) Cancer Res., 48, pp. 5071-5078
  • Scatchard, G., (1949) Ann. NY Acad. Sci., 51, pp. 660-672
  • Stewart, A.J., Johnson, M.D., May, F.E.B., Westley, B.R., (1990) J. Biol. Chem., 265, pp. 21172-21178
  • Swantek, J.L., Baserga, R., (1999) Endocrinology, 140, pp. 3163-3169
  • Taverna, D., Antoniotti, S., Maggiora, P., Dati, C., De Bortoli, M., Hynes, N.E., (1994) Int. J. Cancer, 56, pp. 522-528
  • Tzahar, E., Waterman, H., Chen, X., Levkowitz, G., Karunagaran, D., Lavi, S., Ratzkin, B.J., Yarden, Y., (1996) Mol. Cell. Biol., 16, pp. 5276-5287
  • Ullrich, A., Coussens, L., Hayflick, J.S., Dull, T.J., Gray, A., Tam, A.W., Lee, J., Seeburh, P.H., (1984) Nature, 309, pp. 418-425
  • Ullrich, A., Gray, A., Tam, A.W., Yan-Feng, T., Tsubokawa, M., Collins, C., Hensel, W., Fujita-Yamaguchi, Y., (1986) EMBO J., 5, pp. 2503-2512
  • Van der Geer, P., Hunter, T., Lindberg, R.A., (1994) Annu. Rev. Cell. Biol., 10, pp. 251-337
  • Woods-Ignatoski, K.M., Lapointe, A.J., Radany, E.H., Ethier, S.P., (1999) Endocrinology, 140, pp. 3615-3622
  • Yamamoto, T., Ikawa, S., Akiyama, T., (1986) Nature, 319, pp. 230-234

Citas:

---------- APA ----------
Balãá, M.E., Labriola, L., Salatino, M., Movsichoff, F., Peters, G., Charreau, E.H. & Elizalde, P.V. (2001) . Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insalia-like growth factor receptor in mammary tumor cells. Oncogene, 20(1), 34-47.
http://dx.doi.org/10.1038/sj.onc.1204050
---------- CHICAGO ----------
Balãá, M.E., Labriola, L., Salatino, M., Movsichoff, F., Peters, G., Charreau, E.H., et al. "Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insalia-like growth factor receptor in mammary tumor cells" . Oncogene 20, no. 1 (2001) : 34-47.
http://dx.doi.org/10.1038/sj.onc.1204050
---------- MLA ----------
Balãá, M.E., Labriola, L., Salatino, M., Movsichoff, F., Peters, G., Charreau, E.H., et al. "Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insalia-like growth factor receptor in mammary tumor cells" . Oncogene, vol. 20, no. 1, 2001, pp. 34-47.
http://dx.doi.org/10.1038/sj.onc.1204050
---------- VANCOUVER ----------
Balãá, M.E., Labriola, L., Salatino, M., Movsichoff, F., Peters, G., Charreau, E.H., et al. Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insalia-like growth factor receptor in mammary tumor cells. Oncogene. 2001;20(1):34-47.
http://dx.doi.org/10.1038/sj.onc.1204050