Abstract:
The binding of NO to the iron heme in guanylate cyclase and other heme proteins induces the cleavage of the proximal histidine bonded to the metal. In this study we assess by means of density functional theory (DFT) electronic structure calculations the role of H-bonding to histidine in the modulation of this effect. We have considered in the first place a model of the isolated active site coordinated with imidazole and imidazolate to mimic the effects of a very strong H-bond. We have also investigated four selected ferrous heme proteins with different proximal histidine environments: the O2 sensing FixL, horseradish peroxidase C, and the α and β subunits of human hemoglobin. Our results indicate that polarization and charge transfer effects associated with H-bonding to the proximal histidine play a fundamental role in the modulation of the NO trans effect in heme proteins. We also find computational evidence suggesting that protein structural constraints may affect significantly the cleavage of the Fe-His bond.
Registro:
Documento: |
Artículo
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Título: | Modulation of the NO trans effect in heme proteins: Implications for the activation of soluble guanylate cyclase |
Autor: | Martí, M.A.; Scherlis, D.A.; Doctorovich, F.A.; Ordejón, P.; Estrin, D.A. |
Filiación: | Depto. Quim. Inorg. A. Quim. Fis., Fac. de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires, Argentina Inst. Cie. de Mat. de Barcelona-CSIC, Campus de la UAB, 08193 Bellaterra, Barcelona, Spain
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Palabras clave: | Density functional theory; Guanylate cyclase; Heme proteins; Nitric oxide trans effect; guanylate cyclase; hemoglobin; hemoglobin alpha chain; hemoglobin beta chain; hemoprotein; histidine; horseradish peroxidase; horseradish peroxidase c; imidazole derivative; iron; nitric oxide; oxygen; soluble guanylate cyclase; unclassified drug; article; density functional theory; enzyme activation; enzyme active site; geometry; hydrogen bond; model; polarization; priority journal; protein binding; protein degradation; protein structure; Binding Sites; Enzyme Activation; Guanylate Cyclase; Heme; Hemeproteins; Histidine; Humans; Hydrogen Bonding; Imidazoles; Models, Chemical; Nitric Oxide; Solubility; Armoracia rusticana |
Año: | 2003
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Volumen: | 8
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Número: | 6
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Página de inicio: | 595
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Página de fin: | 600
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DOI: |
http://dx.doi.org/10.1007/s00775-003-0452-9 |
Título revista: | Journal of Biological Inorganic Chemistry
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Título revista abreviado: | J. Biol. Inorg. Chem.
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ISSN: | 09498257
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CODEN: | JJBCF
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CAS: | guanylate cyclase, 9054-75-5; hemoglobin, 9008-02-0; histidine, 645-35-2, 7006-35-1, 71-00-1; iron, 14093-02-8, 53858-86-9, 7439-89-6; nitric oxide, 10102-43-9; oxygen, 7782-44-7; Guanylate Cyclase, EC 4.6.1.2; Heme, 14875-96-8; Hemeproteins; Histidine, 71-00-1; Imidazoles; Nitric Oxide, 10102-43-9
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09498257_v8_n6_p595_Marti |
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Citas:
---------- APA ----------
Martí, M.A., Scherlis, D.A., Doctorovich, F.A., Ordejón, P. & Estrin, D.A.
(2003)
. Modulation of the NO trans effect in heme proteins: Implications for the activation of soluble guanylate cyclase. Journal of Biological Inorganic Chemistry, 8(6), 595-600.
http://dx.doi.org/10.1007/s00775-003-0452-9---------- CHICAGO ----------
Martí, M.A., Scherlis, D.A., Doctorovich, F.A., Ordejón, P., Estrin, D.A.
"Modulation of the NO trans effect in heme proteins: Implications for the activation of soluble guanylate cyclase"
. Journal of Biological Inorganic Chemistry 8, no. 6
(2003) : 595-600.
http://dx.doi.org/10.1007/s00775-003-0452-9---------- MLA ----------
Martí, M.A., Scherlis, D.A., Doctorovich, F.A., Ordejón, P., Estrin, D.A.
"Modulation of the NO trans effect in heme proteins: Implications for the activation of soluble guanylate cyclase"
. Journal of Biological Inorganic Chemistry, vol. 8, no. 6, 2003, pp. 595-600.
http://dx.doi.org/10.1007/s00775-003-0452-9---------- VANCOUVER ----------
Martí, M.A., Scherlis, D.A., Doctorovich, F.A., Ordejón, P., Estrin, D.A. Modulation of the NO trans effect in heme proteins: Implications for the activation of soluble guanylate cyclase. J. Biol. Inorg. Chem. 2003;8(6):595-600.
http://dx.doi.org/10.1007/s00775-003-0452-9