Artículo

Páez Pereda, M.; Lohrer, P.; Kovalovsky, D.; Perez Castro, C.; Goldberg, V.; Losa, M.; Chervín, A.; Berner, S.; Molina, H.; Stalla, G.K.; Renner, U.; Arzt, E. "Interleukin-6 is inhibited by glucocorticoids and stimulates ACTH secretion and POMC expression in human corticotroph pituitary adenomas" (2000) Experimental and Clinical Endocrinology and Diabetes. 108(3):202-207
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Abstract:

Interleukins and their receptors are expressed intrinsically in the anterior pituitary and regulate hormone production and cell proliferation. It has previously been shown that interleukin-6 (IL-6) regulates hormone secretion in normal pituitary cells and cell lines. Here we examined the effects of IL-6 on propiomelanocortin (POMC) expression and ACTH production in corticotroph adenoma cells in vitro. We found that IL-6 stimulates both ACTH secretion and POMC gene expression in corticotroph adenoma cell cultures. This first demonstration of the stimulatory action of IL-6 on human corticotroph adenoma cell function provides further evidence for a direct action of IL-6 on corticotroph pituitary cells. We have confirmed previous reports of IL-6 production by corticotroph adenoma cells and in addition, demonstrated for the first time that the synthetic glucocorticoid dexamethasone is a potent suppressor of intratumoral IL-6 production. This intratumoral produced IL-6 may be in part responsible, in an autocrine manner, for the stimulation of ACTH synthesis and secretion. Our results suggest that IL-6 might play a role in the pathogenesis of Cushing's disease. However, elevated glucocorticoid levels in patients with Cushing's disease may prevent excessive action of IL-6 on ACTH production and tumor progression of corticotroph adenomas in vivo.

Registro:

Documento: Artículo
Título:Interleukin-6 is inhibited by glucocorticoids and stimulates ACTH secretion and POMC expression in human corticotroph pituitary adenomas
Autor:Páez Pereda, M.; Lohrer, P.; Kovalovsky, D.; Perez Castro, C.; Goldberg, V.; Losa, M.; Chervín, A.; Berner, S.; Molina, H.; Stalla, G.K.; Renner, U.; Arzt, E.
Filiación:Max-Planck Institute of Psychiatry, Dept. of Endocrinology, Munich, Germany
Lab. de Fisiol. y Biologia Molecular, Departamento de Biología, FCEN Universidad de Buenos Aires, Buenos Aires, Argentina
Argentine National Research Council, Argentina
Inst. de Invest. Médicas, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
Hospitale San Raffaele, Dept. of Neurosurgery, Milano, Italy
Hospital Santa Lucía, Buenos Aires, Argentina
Hospital Ramos Mejía, Buenos Aires, Argentina
Max Planck Institute of Psychiatry, Dept. of Endocrinology, Kraepelinstr. 10, D-80804 Munich, Germany
Palabras clave:ACTH; Corticotroph adenoma; Interleukin-6; Proopiomelanocortin; corticotropin; dexamethasone; interleukin 6; proopiomelanocortin; adult; article; clinical article; controlled study; cytokine release; female; gene expression; hormone release; human; human cell; human tissue; hypophysis tumor; male; priority journal; Adenoma; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; Male; Middle Aged; Pituitary Neoplasms; Pro-Opiomelanocortin; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured
Año:2000
Volumen:108
Número:3
Página de inicio:202
Página de fin:207
DOI: http://dx.doi.org/10.1055/s-2000-7887
Título revista:Experimental and Clinical Endocrinology and Diabetes
Título revista abreviado:Exp. Clin. Endocrinol. Diabetes
ISSN:09477349
CODEN:ECEDF
CAS:corticotropin, 11136-52-0, 9002-60-2, 9061-27-2; dexamethasone, 50-02-2; proopiomelanocortin, 66796-54-1; Adrenocorticotropic Hormone, 9002-60-2; Interleukin-6; Pro-Opiomelanocortin, 66796-54-1; RNA, Messenger; Recombinant Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09477349_v108_n3_p202_PaezPereda

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Citas:

---------- APA ----------
Páez Pereda, M., Lohrer, P., Kovalovsky, D., Perez Castro, C., Goldberg, V., Losa, M., Chervín, A.,..., Arzt, E. (2000) . Interleukin-6 is inhibited by glucocorticoids and stimulates ACTH secretion and POMC expression in human corticotroph pituitary adenomas. Experimental and Clinical Endocrinology and Diabetes, 108(3), 202-207.
http://dx.doi.org/10.1055/s-2000-7887
---------- CHICAGO ----------
Páez Pereda, M., Lohrer, P., Kovalovsky, D., Perez Castro, C., Goldberg, V., Losa, M., et al. "Interleukin-6 is inhibited by glucocorticoids and stimulates ACTH secretion and POMC expression in human corticotroph pituitary adenomas" . Experimental and Clinical Endocrinology and Diabetes 108, no. 3 (2000) : 202-207.
http://dx.doi.org/10.1055/s-2000-7887
---------- MLA ----------
Páez Pereda, M., Lohrer, P., Kovalovsky, D., Perez Castro, C., Goldberg, V., Losa, M., et al. "Interleukin-6 is inhibited by glucocorticoids and stimulates ACTH secretion and POMC expression in human corticotroph pituitary adenomas" . Experimental and Clinical Endocrinology and Diabetes, vol. 108, no. 3, 2000, pp. 202-207.
http://dx.doi.org/10.1055/s-2000-7887
---------- VANCOUVER ----------
Páez Pereda, M., Lohrer, P., Kovalovsky, D., Perez Castro, C., Goldberg, V., Losa, M., et al. Interleukin-6 is inhibited by glucocorticoids and stimulates ACTH secretion and POMC expression in human corticotroph pituitary adenomas. Exp. Clin. Endocrinol. Diabetes. 2000;108(3):202-207.
http://dx.doi.org/10.1055/s-2000-7887