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Sterle, H.A.; Barreiro Arcos, M.L.; Valli, E.; Paulazo, M.A.; Méndez Huergo, S.P.; Blidner, A.G.; Cayrol, F.; Díaz Flaqué, M.C.; Klecha, A.J.; Medina, V.A.; Colombo, L.; Rabinovich, G.A.; Cremaschi, G.A. "The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies" (2016) Journal of Molecular Medicine. 94(4):417-429
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Abstract:

Abstract: In spite of considerable evidence on the regulation of immunity by thyroid hormones, the impact of the thyroid status in tumor immunity is poorly understood. Here, we evaluated the antitumor immune responses evoked in mice with different thyroid status (euthyroid, hyperthyroid, and hypothyroid) that developed solid tumors or metastases after inoculation of syngeneic T lymphoma cells. Hyperthyroid mice showed increased tumor growth along with increased expression of cell cycle regulators compared to hypothyroid and control tumor-bearing mice. However, hypothyroid mice showed a higher frequency of metastases than the other groups. Hyperthyroid mice bearing tumors displayed a lower number of tumor-infiltrating T lymphocytes, lower percentage of functional IFN-γ-producing CD8+ T cells, and higher percentage of CD19+ B cells than euthyroid tumor-bearing mice. However, no differences were found in the distribution of lymphocyte subpopulations in tumor-draining lymph nodes (TDLNs) or spleens among different experimental groups. Interestingly, hypothyroid TDLN showed an increased percentage of regulatory T (Treg) cells, while hyperthyroid mice displayed increased number and activity of splenic NK cells, which frequency declined in spleens from hypothyroid mice. Moreover, a decreased number of splenic myeloid-derived suppressor cells (MDSCs) were found in tumor-bearing hyperthyroid mice as compared to hypothyroid or euthyroid mice. Additionally, hyperthyroid mice showed increased cytotoxic activity, which declined in hypothyroid mice. Thus, low levels of intratumoral cytotoxic activity would favor tumor local growth in hyperthyroid mice, while regional and systemic antitumor response may contribute to tumor dissemination in hypothyroid animals. Our results highlight the importance of monitoring the thyroid status in patients with T cell lymphomas. Key messages: T cell lymphoma phenotype is paradoxically influenced by thyroid status.Hyperthyroidism favors tumor growth and hypothyroidism rises tumor dissemination.Thyroid status affects the distribution of immune cell types in the tumor milieu.Thyroid status also modifies the nature of local and systemic immune responses. © 2015, Springer-Verlag Berlin Heidelberg.

Registro:

Documento: Artículo
Título:The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies
Autor:Sterle, H.A.; Barreiro Arcos, M.L.; Valli, E.; Paulazo, M.A.; Méndez Huergo, S.P.; Blidner, A.G.; Cayrol, F.; Díaz Flaqué, M.C.; Klecha, A.J.; Medina, V.A.; Colombo, L.; Rabinovich, G.A.; Cremaschi, G.A.
Filiación:Instituto de Investigaciones Biomédicas (BIOMED), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina (UCA), Buenos Aires, Argentina
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad de Buenos Aires (UBA), Buenos Aires, Argentina
Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina
Area de Investigación, Instituto de Oncología “Angel H. Roffo”, UBA, CONICET, Buenos Aires, Argentina
Laboratorio de Radioisótopos, Facultad de Farmacia y Bioquímica (FFyB), UBA, Buenos Aires, Argentina
Palabras clave:Antitumor immune response; Apoptosis; Proliferation; T cell lymphoma; Thyroid hormones; CD9 antigen; gamma interferon; propylthiouracil; thyroid hormone; thyroid hormone; animal cell; animal experiment; apoptosis; Article; B lymphocyte; cancer growth; CD8+ T lymphocyte; cell cycle; cell proliferation; controlled study; cytotoxic T lymphocyte; cytotoxicity; euthyroidism; female; hyperthyroidism; hypothyroidism; immune response; immunocompetent cell; lymphocyte function; mouse; natural killer cell; nonhuman; spleen; suppressor cell; T cell lymphoma; T lymphocyte; T lymphocyte subpopulation; T-Cell lymphoma cell line; tumor cell inoculation; tumor microenvironment; animal; cell line; complication; disease model; drug effects; hyperthyroidism; hypothyroidism; immunology; immunomodulation; lymphocyte count; metabolism; metastasis; pathology; T cell lymphoma; thyroid disease; tumor volume; Animals; Apoptosis; Cell Line; Cell Proliferation; Disease Models, Animal; Female; Hyperthyroidism; Hypothyroidism; Immunomodulation; Lymphocyte Count; Lymphoma, T-Cell; Mice; Neoplasm Metastasis; T-Lymphocyte Subsets; Thyroid Diseases; Thyroid Hormones; Tumor Burden; Tumor Microenvironment
Año:2016
Volumen:94
Número:4
Página de inicio:417
Página de fin:429
DOI: http://dx.doi.org/10.1007/s00109-015-1363-2
Título revista:Journal of Molecular Medicine
Título revista abreviado:J. Mol. Med.
ISSN:09462716
CODEN:JMLME
CAS:gamma interferon, 82115-62-6; propylthiouracil, 51-52-5; Thyroid Hormones
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09462716_v94_n4_p417_Sterle

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Citas:

---------- APA ----------
Sterle, H.A., Barreiro Arcos, M.L., Valli, E., Paulazo, M.A., Méndez Huergo, S.P., Blidner, A.G., Cayrol, F.,..., Cremaschi, G.A. (2016) . The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies. Journal of Molecular Medicine, 94(4), 417-429.
http://dx.doi.org/10.1007/s00109-015-1363-2
---------- CHICAGO ----------
Sterle, H.A., Barreiro Arcos, M.L., Valli, E., Paulazo, M.A., Méndez Huergo, S.P., Blidner, A.G., et al. "The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies" . Journal of Molecular Medicine 94, no. 4 (2016) : 417-429.
http://dx.doi.org/10.1007/s00109-015-1363-2
---------- MLA ----------
Sterle, H.A., Barreiro Arcos, M.L., Valli, E., Paulazo, M.A., Méndez Huergo, S.P., Blidner, A.G., et al. "The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies" . Journal of Molecular Medicine, vol. 94, no. 4, 2016, pp. 417-429.
http://dx.doi.org/10.1007/s00109-015-1363-2
---------- VANCOUVER ----------
Sterle, H.A., Barreiro Arcos, M.L., Valli, E., Paulazo, M.A., Méndez Huergo, S.P., Blidner, A.G., et al. The thyroid status reprograms T cell lymphoma growth and modulates immune cell frequencies. J. Mol. Med. 2016;94(4):417-429.
http://dx.doi.org/10.1007/s00109-015-1363-2