Artículo
Abstract:
Three fractions of fucoidans isolated from the brown seaweed Leathesia difformis (Ee, Ec and Ea) were found to be selective antiviral agents against herpes simplex virus (HSV) types 1 and 2 and human cytomegalovirus. Fraction Ea was the most active, with IC50 values in the range 0.5-1.9 microg/ml without affecting cell viability at concentrations up to 400 microg/ml. The antiherpetic activity of Ea was assessed by three different methods, plaque reduction, inhibition of virus yield and prevention of HSV-2 induced shut-off of cell protein synthesis, demonstrating that the inhibitory effect was independent of the antiviral assay and the multiplicity of infection. The mode of action of Ea could be ascribed to an inhibitory action on virus adsorption. The fucoidans did not inhibit the blood coagulation process even at concentrations exceeding more than 100 times the IC50 value.
Registro:
| Documento: | Artículo |
| Título: | Antiviral properties of fucoidan fractions from Leathesia difformis. |
| Autor: | Feldman, S.C.; Reynaldi, S.; Stortz, C.A.; Cerezo, A.S.; Damont, E.B. |
| Filiación: | Departamento de Química Orgánica-CIHIDECAR, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Argentina |
| Palabras clave: | anticoagulant agent; antivirus agent; fucoidin; polysaccharide; adsorption; animal; article; brown alga; cell line; cell survival; Cercopithecus; chemistry; drug effect; Herpes simplex virus 2; human; IC 50; physiology; seaweed; Vero cell; virology; Adsorption; Algae, Brown; Animals; Anticoagulants; Antiviral Agents; Cell Line; Cell Survival; Cercopithecus aethiops; Herpesvirus 2, Human; Humans; Inhibitory Concentration 50; Polysaccharides; Seaweed; Vero Cells |
| Año: | 1999 |
| Volumen: | 6 |
| Número: | 5 |
| Página de inicio: | 335 |
| Página de fin: | 340 |
| DOI: | http://dx.doi.org/10.1016/S0944-7113(99)80055-5 |
| Título revista: | Phytomedicine : international journal of phytotherapy and phytopharmacology |
| Título revista abreviado: | Phytomedicine |
| ISSN: | 09447113 |
| CAS: | fucoidin, 9072-19-9; Anticoagulants; Antiviral Agents; fucoidan, 9072-19-9; Polysaccharides |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09447113_v6_n5_p335_Feldman |
Citas:
---------- APA ----------
Feldman, S.C., Reynaldi, S., Stortz, C.A., Cerezo, A.S. & Damont, E.B. (1999) . Antiviral properties of fucoidan fractions from Leathesia difformis. Phytomedicine : international journal of phytotherapy and phytopharmacology, 6(5), 335-340.http://dx.doi.org/10.1016/S0944-7113(99)80055-5
---------- CHICAGO ----------
Feldman, S.C., Reynaldi, S., Stortz, C.A., Cerezo, A.S., Damont, E.B. "Antiviral properties of fucoidan fractions from Leathesia difformis." Phytomedicine : international journal of phytotherapy and phytopharmacology 6, no. 5 (1999) : 335-340.http://dx.doi.org/10.1016/S0944-7113(99)80055-5
---------- MLA ----------
Feldman, S.C., Reynaldi, S., Stortz, C.A., Cerezo, A.S., Damont, E.B. "Antiviral properties of fucoidan fractions from Leathesia difformis." Phytomedicine : international journal of phytotherapy and phytopharmacology, vol. 6, no. 5, 1999, pp. 335-340.http://dx.doi.org/10.1016/S0944-7113(99)80055-5
---------- VANCOUVER ----------
Feldman, S.C., Reynaldi, S., Stortz, C.A., Cerezo, A.S., Damont, E.B. Antiviral properties of fucoidan fractions from Leathesia difformis. Phytomedicine. 1999;6(5):335-340.http://dx.doi.org/10.1016/S0944-7113(99)80055-5
