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Abstract:

In rural populations, the proximity to areas with intensive pesticide application represents a risk factor of xenobiotic exposure. Here, we investigated whether newborns born to mothers residing in an area with intensive pesticide application show alterations in placental and neonatal morphometric standards, umbilical cord blood (UCB) biochemical parameters, and/or biomarkers related to oxidative stress and oxidative damage. Samples were collected from 151 healthy pregnant women residing in a rural area (rural group; RG) during the pesticide spraying (SS) and nonspraying (NSS) seasons, as well as from women from an urban population (control group; CG), and grouped according to the delivery type (vaginal or cesarean). In the vaginal delivery group, the placental weight and placental index were higher in the RG groups than in the CG (p = 0.01), whereas in the cesarean delivery group, newborn weight was lower in the RG-SS group than in the CG. In the RG-SS group, UCB erythrocyte osmotic fragility and the DNA damage index (DI) were higher, and superoxide dismutase (SOD) activity was lower than in the RG-NSS group. Acetylcholinesterase and SOD activities were found to be inversely correlated with the DI. © 2017, Springer-Verlag GmbH Germany.

Registro:

Documento: Artículo
Título:Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application
Autor:Quintana, M.M.; Vera, B.; Magnarelli, G.; Guiñazú, N.; Rovedatti, M.G.
Filiación:Facultad de Ciencias Médicas, Universidad Nacional del Comahue, Av. Luis Toschi y Los Arrayanes, Cipolletti, Río Negro 8324, Argentina
Centro de Investigaciones en Toxicología Ambiental y Agrobiotecnología del Comahue (CITAAC), CONICET, Universidad Nacional del Comahue, Buenos Aires 1400, Neuquén, 8300, Argentina
Departamento de Ciencias del Ambiente, Facultad de Ciencias del Ambiente y la Salud, Universidad Nacional del Comahue, Buenos Aires 1400, Neuquén, 8300, Argentina
Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Intendente Güiraldes 2160, Buenos Aires, C1428EGA, Argentina
Laboratorio de Toxicología de Mezclas Químicas (LATOMEQ), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II, 4to piso, Intendente Güiraldes 2160, Buenos Aires, C1428EGA, Argentina
Palabras clave:DNA damage; Neonate parameters; Osmotic fragility; Residential exposure; Superoxide dismutase; Umbilical cord blood; biomarker; blood; DNA; enzyme; enzyme activity; health risk; neonate; osmosis; oxidative stress; pesticide application; pregnancy; public health; risk factor; rural area; rural population; urban population; womens health; biological marker; pesticide; adolescent; adult; Argentina; blood; chemistry; female; fetus blood; human; newborn; oxidative stress; placenta; pregnancy; rural population; urban population; vascularization; young adult; Adolescent; Adult; Argentina; Biomarkers; Female; Fetal Blood; Humans; Infant, Newborn; Oxidative Stress; Pesticides; Placenta; Pregnancy; Rural Population; Urban Population; Young Adult
Año:2017
Volumen:24
Número:25
Página de inicio:20736
Página de fin:20746
DOI: http://dx.doi.org/10.1007/s11356-017-9642-9
Título revista:Environmental Science and Pollution Research
Título revista abreviado:Environ. Sci. Pollut. Res.
ISSN:09441344
CODEN:ESPLE
CAS:Biomarkers; Pesticides
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09441344_v24_n25_p20736_Quintana

Referencias:

  • Acosta-Maldonado, B., Sánchez-Ramírez, B., Reza-López, S., Levario-Carrillo, M., Effects of exposure to pesticides during pregnancy on placental maturity and weight of newborns: a cross-sectional pilot study in women from the Chihuahua State, Mexico (2009) Hum Exp Toxicol, 28 (8), pp. 451-459. , COI: 1:CAS:528:DC%2BD1MXhsVertL3N
  • Ambali, S.F., Ayo, J.O., Ojo, S.A., Esievo, K.A.N., Vitamin E protects Wistar rats from chlorpyrifos-induced increase in erythrocyte osmotic fragility (2010) Food Chem Toxicol, 48 (12), pp. 3477-3480. , COI: 1:CAS:528:DC%2BC3cXhtlKrs7nI
  • Angerer, J., Ewers, U., Wilhelm, M., Human biomonitoring: state of the art (2007) Int J Hyg Environ Health, 210 (3), pp. 201-228. , COI: 1:CAS:528:DC%2BD2sXnsVKitrg%3D
  • Argentin, G., Divizia, M., Cicchetti, R., Oxidative stress, cytotoxicity, and genotoxicity induced by methyl parathion in human gingival fibroblasts: protective role of epigallocatechin-3-gallate (2015) J Toxicol Environ Health A, 78 (19), pp. 1227-1240. , COI: 1:CAS:528:DC%2BC2MXhslaksbfK
  • Bal, R., Türk, G., Yılmaz, Ö., Etem, E., Kuloğlu, T., Baydaş, G., Naziroğlu, M., Effects of clothianidin exposure on sperm quality, testicular apoptosis and fatty acid composition in developing male rats (2012) Cell Biol Toxicol, 28 (3), pp. 187-200. , COI: 1:CAS:528:DC%2BC38XmtFehtLw%3D
  • Bautista, M.L.G., Altaf, W., Lall, R., Wapnir, R.A., Cord blood red cell osmotic fragility: a comparison between preterm and full-term newborn infants (2003) Early Hum Develop, 72 (1), pp. 37-46
  • Ben Amara, I., Karray, A., Hakim, A., Ben Ali, Y., Troudi, A., Soudani, N., Boudawara, T., Zeghal, N., Dimethoate induces kidney dysfunction, disrupts membrane-bound ATPases and confers cytotoxicity through DNA damage. Protective effects of vitamin E and selenium (2013) Biol Trace Elem Res, 156 (1-3), pp. 230-242. , COI: 1:CAS:528:DC%2BC3sXhs1Sns7rM
  • Bhuiyan, M., Murad, F., Fant, M., The placental cholinergic system: localization to the cytotrophoblast and modulation of nitric oxide (2006) Cell Commun Signal, 4, p. 4
  • Bulgaroni, V., Lombardo, P., Rivero-Osimani, V., Vera, B., Dulgerian, L., Cerbán, F., Guiñazú, N., Environmental pesticide exposure modulates cytokines, arginase and ornithine decarboxylase expression in human placenta (2013) Reprod Toxicol, 39, pp. 23-32. , COI: 1:CAS:528:DC%2BC3sXptFOls7k%3D
  • Burkhardt, T., Schäffer, L., Schneider, C., Zimmermann, R., Kurmanavicius, J., Reference values for the weight of freshly delivered term placentas and for placental weight-birth weight ratios (2006) Eur J Obstet Gyn R B, 128 (1-2), pp. 248-252
  • Camkurt, M.A., Fındıkl, E., İnanç Tolun, F., Bakacak, M., Gül Bal, N., Sakall, H., Güneş, M., Probable preventive effects of placenta from oxidative stress; evaluation of total antioxidant status, total oxidant status and oxidative stress index in fetal cord blood during the delivery (2016) Psychiatry Res, 240, pp. 222-225. , COI: 1:CAS:528:DC%2BC28XmslOjurg%3D
  • Cecchi, A., Rovedatti, M.G., Sabino, G., Magnarelli, G.G., Environmental exposure to organophosphate pesticides: assessment of endocrine disruption and hepatotoxicity in pregnant women (2012) Ecotox Environ Safe, 80, pp. 280-287. , COI: 1:CAS:528:DC%2BC38Xms1yls74%3D
  • Chiapella, G., Flores-Martín, J., Ridano, M.E., Reyna, L., Magnarelli De Potas, G., Panzetta-Dutari, G.M., Genti-Raimondi, S., The organophosphate chlorpyrifos disturbs redox balance and triggers antioxidant defense mechanisms in JEG-3 cells (2013) Placenta, 34 (9), pp. 792-798. , COI: 1:CAS:528:DC%2BC3sXhtFSgs7bJ
  • Cindrova-Davies, T., Yung, H.W., Johns, J., Spasic-Boskovic, O., Korolchuk, S., Jauniaux, E., Burton, G.J., Charnock-Jones, D.S., Oxidative stress, gene expression, and protein changes induced in the human placenta during labor (2007) Am J Pathol, 171 (4), pp. 1168-1179. , COI: 1:CAS:528:DC%2BD2sXht1SmsbfE
  • Davidsohn, I., Henry, JB (1978) Clinical diagnosis by the laboratory. Todd - Sandford (Salvat), 6th edition Barcelona, , in spanish
  • Ding, F., Peng, W., Biological assessment of neonicotinoids imidacloprid and its major metabolites for potentially human health using globular proteins as a model (2015) J Photochem Photobiol B, 147, pp. 24-36. , COI: 1:CAS:528:DC%2BC2MXlsVSrtbY%3D
  • Dusinska, M., Collins, A.R., The comet assay in human biomonitoring: gene-environment interactions (2008) Mutagenesis, 23 (3), pp. 191-205. , COI: 1:CAS:528:DC%2BD1cXlsVGltL4%3D
  • El-Bini Dhouib, I., Lasram, M.M., Annabi, A., Gharbi, N., El-Fazaa, S., A comparative study on toxicity induced by carbosulfan and malathion in Wistar rat liver and spleen (2015) Pestic Biochem Physiol, 124, pp. 21-28. , COI: 1:CAS:528:DC%2BC2MXmt1Wktbk%3D
  • Ertabak, A., Kutluay, T., Ünlü, A., Türközkan, N., Çimen, B., Yaman, H., The effect of desferrioxamine on peroxynitrite-induced oxidative damage in erythrocytes (2004) Cell Biochem Funct, 22 (3), pp. 149-152. , COI: 1:CAS:528:DC%2BD2cXksVyrt7o%3D
  • Eskenazi, B., Harley, K., Bradman, A., Weltzien, E., Jewell, N.P., Barr, D.B., Furlong, C.E., Holland, N.T., Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population (2004) Environ Health Perspect, 112, pp. 1116-1124. , COI: 1:CAS:528:DC%2BD2cXps1agsbc%3D
  • Flaskos, J., The developmental neurotoxicity of organophosphorus insecticides: a direct role for the oxon metabolites (2012) Toxicol Lett, 209 (1), pp. 86-93. , COI: 1:CAS:528:DC%2BC38XlsFClug%3D%3D
  • Grandi, C., Veiga, A., Mazzitelli, N., Cavalli Rde, C., Cardoso, V., Placental growth measures in relation to birth weight in a latin american population (2016) Rev Bras Ginecol Obstet, 38 (8), pp. 373-380
  • Huerga, M., San Juan, S., (2009) Pest control in Argentine agriculture (in Spanish), , FAO Investment Centre Report
  • Loewy, R.M., Monza, L.B., Kirs, V.E., Savini, M.C., Pesticide distribution in an agricultural environment in Argentina (2011) J Environ Sci Health B, 46 (8), pp. 662-670. , COI: 1:CAS:528:DC%2BC3MXhtFGiu7bF
  • Londero, A., Bertozzi, S., Visentin, S., Fruscalzo, A., Driul, L., Marchesoni, D., High placental index and poor pregnancy outcomes: a retrospective study of 18 386 pregnancies (2013) Gynecol Endocrinol, 29 (7), pp. 666-669
  • López, O., Hernández, A.F., Rodrigo, L., Gil, F., Pena, G., Serrano, J.L., Pla, A., Changes in antioxidant enzymes in humans with long-term exposure to pesticides (2007) Toxicol Lett, 171 (3), pp. 146-153
  • Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the Folin phenol reagent (1951) J Biol Chem, 193, pp. 265-275
  • Lukaszewicz-Hussain, A., Role of oxidative stress in organophosphate insecticide toxicity—short review (2010) Pest Biochem Physiol, 98 (2), pp. 145-150. , COI: 1:CAS:528:DC%2BC3cXhtFGjtrbO
  • Macdonald, E.M., Natale, R., Regnault, T.R., Koval, J.J., Campbell, M.K., Obstetric conditions and the placental weight ratio (2014) Placenta, 35 (8), pp. 582-586. , COI: 1:STN:280:DC%2BC2cfgtlShtw%3D%3D
  • Mohorovic, L., Petrovic, O., Haller, H., Micovic, V., Pregnancy loss and maternal methemoglobin levels: an indirect explanation of the association of environmental toxics and their adverse effects on the mother and the fetus (2010) Int J Environ Res Public Health, 7 (12), pp. 4203-4212
  • Mostafalou, S., Abdollahi, M., Pesticides and human chronic diseases: evidences, mechanisms, and perspectives (2013) Toxicol App Pharmacol, 268 (2), pp. 157-161. , COI: 1:CAS:528:DC%2BC3sXktlOjt74%3D
  • Mwila, K., Burton, M.H., Van Dyk, J.S., Pletschke, B.I., The effect of mixtures of organophosphate and carbamate pesticides on acetylcholinesterase and application of chemometrics to identify pesticides in mixtures (2013) Environ Mon Assess, 185 (3), pp. 2315-2327. , COI: 1:CAS:528:DC%2BC3sXhs1antLc%3D
  • Naksen, W., Prapamontol, T., Mangklabruks, A., Chantara, S., Thavornyutikarn, P., Srinual, N., Barr, D.B., Associations of maternal organophosphate pesticide exposure and PON1 activity with birth outcomes in SAWASDEE birth cohort (2015) Thailand Environ Res, 142, pp. 288-296. , COI: 1:CAS:528:DC%2BC2MXhtFOksbjJ
  • Noh, E., Kim, Y., Cho, M., Comparison of oxidative stress markers in umbilical cord blood after vaginal and cesarean delivery (2014) Obstet Gynecol Sci, 57 (2), pp. 109-114
  • Prouillac, C., Lecoeur, S., The role of the placenta in fetal exposure to xenobiotics: importance of membrane transporters and human models for transfer studies (2010) Drug Metabol Dispos, 38 (10), pp. 1623-1635. , COI: 1:CAS:528:DC%2BC3cXht1eisLvI
  • Raghunath, G., Vijayalakshmi, Shenoy, V., A study on the morphology and the morphometry of the human placenta and its clinical relevance in a population in Tamilnadu (2011) J Clin Diagn Res, 5 (2), pp. 282-286
  • Raijmakers, M.T., Roes, E.M., Steegers, E.A., van der Wildt, B., Peters, W.H., Umbilical glutathione levels are higher after vaginal birth than after cesarean section (2003) J Perinat Med, 31 (6), pp. 520-522. , COI: 1:CAS:528:DC%2BD2cXmtlOisQ%3D%3D
  • Rivero Osimani, V.L., Valdez, S.R., Guiñazú, N., Magnarelli, G., Alteration of syncytiotrophoblast mitochondria function and endothelial nitric oxide synthase expression in the placenta of rural residents (2016) Reprod Toxicol, 61, pp. 47-57. , COI: 1:CAS:528:DC%2BC28XktVeqsrk%3D
  • Rowe, C., Gunier, R., Bradman, A., Harley, K.G., Kogut, K., Parra, K., Eskenazi, B., Residential proximity to organophosphate and carbamate pesticide use during pregnancy, poverty during childhood, and cognitive functioning in 10-year-old children (2016) Environ Res, 150, pp. 128-137. , COI: 1:CAS:528:DC%2BC28Xps1WksLo%3D
  • Saphier, O., Schneid-Kofman, N., Silberstein, E., Silberstein, T., Does mode of delivery affect neonate oxidative stress in parturition? Review of literature (2013) Arch Gynecol Obstet, 287 (3), pp. 403-406. , COI: 1:CAS:528:DC%2BC3sXis1Citro%3D
  • Simoniello, M.F., Kleinsorge, M.F., Carballo, E.C., Evaluación bioquímica de trabajadores rurales expuestos a pesticidas. Medicina (B (2010) Aires), 70 (6), pp. 489-498. , http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0025-76802010000600001&lang=pt, in Spanish], Retrieved from
  • Souza, M.S., Magnarelli, G.G., Rovedatti, M.G., Santa-Cruz, S., Pechen de D’Angelo, A.M., Prenatal exposure to pesticides: analysis of human placental acetylcholinesterase, glutathione-S-transferase and catalase as biomarkers of effect (2005) Biomarkers, 10 (5), pp. 376-389. , COI: 1:CAS:528:DC%2BD2MXhtFCjtrbE
  • Uchendu, C., Ambali, S.F., Ayo, J.O., Esievo, K.A.N., Umosen, A.J., Erythrocyte osmotic fragility and lipid peroxidation following chronic co-exposure of rats to chlorpyrifos and deltamethrin, and the beneficial effect of alpha-lipoic acid (2014) Toxicol Rep, 1, pp. 373-378. , COI: 1:CAS:528:DC%2BC2MXlvFWktb4%3D
  • Vera, B., Santa Cruz, S., Magnarelli, G., Plasma cholinesterase and carboxylesterase activities and nuclear and mitochondrial lipid composition of human placenta associated with maternal exposure to pesticides (2012) Reprod Toxicol, 34 (3), pp. 402-407. , COI: 1:CAS:528:DC%2BC38Xot12lsLw%3D
  • Voss, G., Sachsse, K., Red cell and plasma cholinesterase activities in microsamples of human and animal blood determined simultaneously by a modified acetylcholine/DTNB procedure (1970) Toxicol App Pharmacol, 16, pp. 764-772. , COI: 1:CAS:528:DyaE3cXksFagu7Y%3D
  • Watanabe, K., Iwasaki, A., Mori, T., Kimura, C., Matsushita, H., Shinohara, K., Wakatsuki, A., Differences in levels of oxidative stress in mothers and neonate: the impact of mode of delivery (2013) J Matern Fetal Neonatal Med, 26 (16), pp. 1649-1652. , COI: 1:CAS:528:DC%2BC3sXhvVGhtLfL
  • Whyatt, R.M., Barr, D.B., Camann, D.E., Kinney, P.L., Barr, J.R., Andrews, H.F., Perera, F.P., Contemporary-use pesticide in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns (2003) Environ Health Perspect, 111 (5), pp. 749-756. , COI: 1:CAS:528:DC%2BD3sXktlequ70%3D
  • Yusa, V., Millet, M., Coscolla, C., Roca, M., Analytical methods for human biomonitoring of pesticides. A review (2015) Anal Chim Acta, 891, pp. 15-31. , COI: 1:CAS:528:DC%2BC2MXhtVejtr%2FM

Citas:

---------- APA ----------
Quintana, M.M., Vera, B., Magnarelli, G., Guiñazú, N. & Rovedatti, M.G. (2017) . Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application. Environmental Science and Pollution Research, 24(25), 20736-20746.
http://dx.doi.org/10.1007/s11356-017-9642-9
---------- CHICAGO ----------
Quintana, M.M., Vera, B., Magnarelli, G., Guiñazú, N., Rovedatti, M.G. "Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application" . Environmental Science and Pollution Research 24, no. 25 (2017) : 20736-20746.
http://dx.doi.org/10.1007/s11356-017-9642-9
---------- MLA ----------
Quintana, M.M., Vera, B., Magnarelli, G., Guiñazú, N., Rovedatti, M.G. "Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application" . Environmental Science and Pollution Research, vol. 24, no. 25, 2017, pp. 20736-20746.
http://dx.doi.org/10.1007/s11356-017-9642-9
---------- VANCOUVER ----------
Quintana, M.M., Vera, B., Magnarelli, G., Guiñazú, N., Rovedatti, M.G. Neonatal, placental, and umbilical cord blood parameters in pregnant women residing in areas with intensive pesticide application. Environ. Sci. Pollut. Res. 2017;24(25):20736-20746.
http://dx.doi.org/10.1007/s11356-017-9642-9