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Abstract:

Olfactory epithelium has the capability to continuously regenerate olfactory receptor neurons throughout life. Adult neurogenesis results from proliferation and differentiation of neural stem cells, and consequently, olfactory neuroepithelium offers an excellent opportunity to study neural regeneration and the factors involved in the maintenance and regeneration of all their cell types. We analyzed the expression of BDNF in the olfactory system under normal physiological conditions as well as during a massive regeneration induced by chemical destruction of the olfactory epithelium in Xenopus laevis larvae. We described the expression and presence of BDNF in the olfactory epithelium and bulb. In normal physiological conditions, sustentacular (glial) cells and a few scattered basal (stem) cells express BDNF in the olfactory epithelium as well as the granular cells in the olfactory bulb. Moreover, during massive regeneration, we demonstrated a drastic increase in basal cells expressing BDNF as well as an increase in BDNF in the olfactory bulb and nerve. Together these results suggest an important role of BDNF in the maintenance and regeneration of the olfactory system. © 2014 Elsevier GmbH.

Registro:

Documento: Artículo
Título:Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis
Autor:Frontera, J.L.; Cervino, A.S.; Jungblut, L.D.; Paz, D.A.
Filiación:Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-CONICET), Universidad de Buenos Aires, Buenos Aires, Argentina
Laboratorio de Biología del Desarrollo, Departamento de Biodiversidad y Biología Experimental, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Neural stem cells; Neurogenesis; Neurotrophins; Olfactory bulb; Olfactory neurons; Sustentacular cells; brain derived neurotrophic factor; zinc sulfate; brain derived neurotrophic factor; animal tissue; Article; controlled study; embryo; glia cell; granular cell; larva; neural stem cell; nonhuman; olfactory bulb; olfactory epithelium; olfactory nerve; protein analysis; protein expression; protein function; tissue regeneration; Xenopus laevis; animal; metabolism; nerve regeneration; nervous system development; olfactory epithelium; pathology; pathophysiology; physiology; Xenopus laevis; Xenopus laevis; Animals; Brain-Derived Neurotrophic Factor; Nerve Regeneration; Neurogenesis; Olfactory Bulb; Olfactory Mucosa; Xenopus laevis
Año:2007
Volumen:198
Página de inicio:41
Página de fin:48
DOI: http://dx.doi.org/10.1016/j.aanat.2014.10.010
Título revista:Annals of Anatomy
ISSN:09409602
CODEN:ANANE
CAS:brain derived neurotrophic factor, 218441-99-7; zinc sulfate, 7733-02-0; Brain-Derived Neurotrophic Factor
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09409602_v198_n_p41_Frontera

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Citas:

---------- APA ----------
Frontera, J.L., Cervino, A.S., Jungblut, L.D. & Paz, D.A. (2007) . Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis. Annals of Anatomy, 198, 41-48.
http://dx.doi.org/10.1016/j.aanat.2014.10.010
---------- CHICAGO ----------
Frontera, J.L., Cervino, A.S., Jungblut, L.D., Paz, D.A. "Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis" . Annals of Anatomy 198 (2007) : 41-48.
http://dx.doi.org/10.1016/j.aanat.2014.10.010
---------- MLA ----------
Frontera, J.L., Cervino, A.S., Jungblut, L.D., Paz, D.A. "Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis" . Annals of Anatomy, vol. 198, 2007, pp. 41-48.
http://dx.doi.org/10.1016/j.aanat.2014.10.010
---------- VANCOUVER ----------
Frontera, J.L., Cervino, A.S., Jungblut, L.D., Paz, D.A. Brain-derived neurotrophic factor (BDNF) expression in normal and regenerating olfactory epithelium of Xenopus laevis. 2007;198:41-48.
http://dx.doi.org/10.1016/j.aanat.2014.10.010