Artículo

Lima, B.; Sánchez, M.; Luna, L.; Agüero, M.B.; Zacchino, S.; Filippa, E.; Palermo, J.A.; Tapia, A.; Feresin, G.E. "Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean slopes of San Juan Province, Argentina" (2012) Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 67(1-2):29-38
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Abstract:

The infusion of the aerial parts of Gentianella multicaulis (Gillies ex Griseb.) Fabris (Gentianaceae), locally known as 'nencia', is used in San Juan Province, Argentina, as stomachic and as a bitter tonic against digestive and liver problems. The bioassay-guided isolation of G. multicaulis extracts and structural elucidation of the main compounds responsible for the antifungal and free radical scavenging activities were performed. The extracts had strong free radical scavenging effects in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay (45-93% at 10 μg/mL) and ferric-reducing antioxidant power (FRAP) assay at 200 μg/mL. Demethylbellidifolin (4) had high antioxidant activity in the DPPH and FRAP assay. The dermatophytes Microsporum gypseum, Trichophyton mentagrophytes, and T. rubrum were moderately inhibited by the different extracts (MIC values of 125-250 μg/mL). Demethylbellidifolin (4), bellidifolin (5), and isobellidifolin (6) showed an antifungal effect (MIC values of 50 μg/mL), while swerchirin (3) was less active with a MIC value of 100 μg/mL. In addition, oleanolic acid (1) and ursolic acid (2) were also isolated. These findings demonstrate that Gentianella multicaulis collected in the mountains of the Province of San Juan, Argentina, is an important source of compounds with antifungal and antioxidant activities. © 2012 Verlag der Zeitschrift für Naturforschung, Tübingen.

Registro:

Documento: Artículo
Título:Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean slopes of San Juan Province, Argentina
Autor:Lima, B.; Sánchez, M.; Luna, L.; Agüero, M.B.; Zacchino, S.; Filippa, E.; Palermo, J.A.; Tapia, A.; Feresin, G.E.
Filiación:Instituto de Biotecnología, Instituto de Ciencias Básicas, Universidad Nacional de San Juan, Av. Libertador General San Martín 1109 oeste, CP 5400, San Juan, Argentina
UMYMFOR, Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón II, Ciudad Universitaria Piso: 3, Buenos Aires, Argentina
Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional del Rosario, Suipacha 531, CP 2000, Rosario, Argentina
Instituto Multidisciplinario de Biología Vegetal, IMBIV (CONICET-UNC), Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Casilla de Correo 495, CP 5000, Córdoba, Argentina
Palabras clave:Antifungal activity; Antioxidant activity; Gentianella multicaulis; Trichophyton spp.; antiinfective agent; antioxidant; scavenger; Argentina; article; chemistry; Gentianella; high performance liquid chromatography; microbiological examination; nuclear magnetic resonance spectroscopy; Anti-Infective Agents; Antioxidants; Argentina; Chromatography, High Pressure Liquid; Free Radical Scavengers; Gentianella; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Arthroderma benhamiae; Arthroderma gypseum; Arthrodermataceae; Gentianaceae; Gentianella; Trichophyton; Trichophyton rubrum
Año:2012
Volumen:67
Número:1-2
Página de inicio:29
Página de fin:38
Título revista:Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Título revista abreviado:Z. Naturforsch. Sect. C J. Biosci.
ISSN:09395075
CODEN:ZNCBD
CAS:Anti-Infective Agents; Antioxidants; Free Radical Scavengers
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09395075_v67_n1-2_p29_Lima

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Citas:

---------- APA ----------
Lima, B., Sánchez, M., Luna, L., Agüero, M.B., Zacchino, S., Filippa, E., Palermo, J.A.,..., Feresin, G.E. (2012) . Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean slopes of San Juan Province, Argentina. Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 67(1-2), 29-38.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09395075_v67_n1-2_p29_Lima [ ]
---------- CHICAGO ----------
Lima, B., Sánchez, M., Luna, L., Agüero, M.B., Zacchino, S., Filippa, E., et al. "Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean slopes of San Juan Province, Argentina" . Zeitschrift fur Naturforschung - Section C Journal of Biosciences 67, no. 1-2 (2012) : 29-38.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09395075_v67_n1-2_p29_Lima [ ]
---------- MLA ----------
Lima, B., Sánchez, M., Luna, L., Agüero, M.B., Zacchino, S., Filippa, E., et al. "Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean slopes of San Juan Province, Argentina" . Zeitschrift fur Naturforschung - Section C Journal of Biosciences, vol. 67, no. 1-2, 2012, pp. 29-38.
Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09395075_v67_n1-2_p29_Lima [ ]
---------- VANCOUVER ----------
Lima, B., Sánchez, M., Luna, L., Agüero, M.B., Zacchino, S., Filippa, E., et al. Antimicrobial and antioxidant activities of Gentianella multicaulis collected on the Andean slopes of San Juan Province, Argentina. Z. Naturforsch. Sect. C J. Biosci. 2012;67(1-2):29-38.
Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09395075_v67_n1-2_p29_Lima [ ]