Artículo
Van Baren, C.; Anao, I.; Lira, P.D.L.; Debenedetti, S.; Houghton, P.; Croft, S.; Martino, V. "Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity" (2006) Zeitschrift fur Naturforschung - Section C Journal of Biosciences. 61(3-4):189-192
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Abstract:
Bioassay-guided fractionation of a Satureja parvifolia MeOH extract led to the isolation of eriodictyol, luteolin and ursolic and oleanolic acids as its active components against Plasmodium falciparum K1. This is the first time these compounds are reported as constituents of S. parvifolia. Ursolic acid showed an IC 50 of 4.9 μg/ml, luteolin 6.4 μg/ml, oleanolic acid 9.3 μg/ml and eriodictyol 17.2 μg/ml. Antiplasmodial activity of eriodictyol and luteolin is reported here for the first time. Besides, the four compounds showed activity against P. falciparum 3D7 strain and Trypanosoma brucei rhodesiense. Eriodictyol showed moderate activity on all the parasites but was the most selective compound as a result of its rather low cytotoxicity (IC 50 174.2 μg/ml) on the mammalian KB cell line. © 2006 Verlag der Zeitschrift für Naturforschung.
Registro:
| Documento: | Artículo |
| Título: | Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity |
| Autor: | Van Baren, C.; Anao, I.; Lira, P.D.L.; Debenedetti, S.; Houghton, P.; Croft, S.; Martino, V. |
| Filiación: | Cátedra de Farmacognosia, Instituto de Química Y Metabolismo del Fármaco IQUIMEFA (UBA-CONICET), Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina Department of Pharmacy, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SEI 8WA, United Kingdom Cátedra de Farmacognosia, Facultad de Ciencias Exactas Y Naturales, Universidad Nacional de La Plata, calle 47 y 115, 1900 La Plata, Argentina Parasitology Department, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1, United Kingdom |
| Idioma: | Inglés |
| Palabras clave: | Antiprotozoal Compounds; Satureja parvifolia; antiprotozoal agent; chloroquine; eriodictyol; flavanone derivative; flavonoid; methanol; oleanolic acid; triterpene; ursolic acid; animal; article; cell survival; chemistry; drug effect; isolation and purification; mass fragmentography; phytotherapy; plant; Plasmodium falciparum; savory; Animals; Antiprotozoal Agents; Cell Survival; Chloroquine; Flavanones; Flavonoids; Gas Chromatography-Mass Spectrometry; Methanol; Oleanolic Acid; Phytotherapy; Plant Components, Aerial; Plasmodium falciparum; Satureja; Triterpenes; Mammalia; Plasmodium falciparum; Satureja; Trypanosoma brucei rhodesiense |
| Año: | 2006 |
| Volumen: | 61 |
| Número: | 3-4 |
| Página de inicio: | 189 |
| Página de fin: | 192 |
| Título revista: | Zeitschrift fur Naturforschung - Section C Journal of Biosciences |
| Título revista abreviado: | Z. Naturforsch. Sect. C J. Biosci. |
| ISSN: | 09395075 |
| CODEN: | ZNCBD |
| CAS: | chloroquine, 132-73-0, 3545-67-3, 50-63-5, 54-05-7; eriodictyol, 552-58-9; methanol, 67-56-1; oleanolic acid, 508-02-1; ursolic acid, 77-52-1; Antiprotozoal Agents; Chloroquine, 54-05-7; eriodictyol, 552-58-9; Flavanones; Flavonoids; Methanol, 67-56-1; Oleanolic Acid, 508-02-1; Triterpenes; ursolic acid, 77-52-1 |
| Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09395075_v61_n3-4_p189_VanBaren |
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Citas:
---------- APA ----------
Van Baren, C., Anao, I., Lira, P.D.L., Debenedetti, S., Houghton, P., Croft, S. & Martino, V. (2006) . Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity. Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 61(3-4), 189-192.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09395075_v61_n3-4_p189_VanBaren [ ]
---------- CHICAGO ----------
Van Baren, C., Anao, I., Lira, P.D.L., Debenedetti, S., Houghton, P., Croft, S., et al. "Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity" . Zeitschrift fur Naturforschung - Section C Journal of Biosciences 61, no. 3-4 (2006) : 189-192.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09395075_v61_n3-4_p189_VanBaren [ ]
---------- MLA ----------
Van Baren, C., Anao, I., Lira, P.D.L., Debenedetti, S., Houghton, P., Croft, S., et al. "Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity" . Zeitschrift fur Naturforschung - Section C Journal of Biosciences, vol. 61, no. 3-4, 2006, pp. 189-192.Recuperado de https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09395075_v61_n3-4_p189_VanBaren [ ]
---------- VANCOUVER ----------
Van Baren, C., Anao, I., Lira, P.D.L., Debenedetti, S., Houghton, P., Croft, S., et al. Triterpenic acids and flavonoids from Satureja parvifolia, evaluation of their antiprotozoal activity. Z. Naturforsch. Sect. C J. Biosci. 2006;61(3-4):189-192.Available from: https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09395075_v61_n3-4_p189_VanBaren [ ]
