Abstract:
Bioassay guided purification of the ethyl acetate extract of leaves of Melia azedarach led to the isolation of the limonoid 1-cinnamoyl-3,11-dihydroxymeliacarpin, which showed IC50 values of 6 μM and 20 μM for vesicular stomatitis (VSV) and herpes simplex (HSV-1) viruses, respectively. Its structure was established by spectroscopic methods.
Registro:
Documento: |
Artículo
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Título: | An antiviral meliacarpin from leaves of Melia azedarach L. |
Autor: | Alché, L.E.; Ferek, G.A.; Meo, M.; Coto, C.E.; Maier, M.S. |
Filiación: | Depto. de Quim. Biológica, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina Depto. de Quim. Orgánica, Universidad de Buenos Aires, Ciudad Universitaria, 1428 Buenos Aires, Argentina
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Palabras clave: | Antiviral Activity; Limonoids; Melia azedarach L.; Melia azedarach; Melia azedarach; Simplexvirus; Vesicular stomatitis virus |
Año: | 2003
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Volumen: | 58
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Número: | 3-4
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Página de inicio: | 215
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Página de fin: | 219
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DOI: |
http://dx.doi.org/10.1515/znc-2003-3-413 |
Título revista: | Zeitschrift fur Naturforschung - Section C Journal of Biosciences
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Título revista abreviado: | Z. Naturforsch. Sect. C J. Biosci.
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ISSN: | 09395075
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CODEN: | ZNCBD
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Registro: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09395075_v58_n3-4_p215_Alche |
Referencias:
- Alché, L.E., Berra, A., Veloso, M.J., Coto, C.E., Treatment with meliacine, a plant derived antiviral prevents the development of herpetic stromal keratitis in mice (2000) J. Med. Virol., 61, pp. 474-480
- Andrei, G., Damonte, E., De Torres, R., Coto, C., Induction of a refractory state to viral infection in mammalian cells by a plant inhibitor isolated from leaves of Melia azedarach L. (1988) Antivir. Res., 9, pp. 221-231
- Bohnenstengel, F.I., Wray, V., Witte, L., Srivastava, R.P., Proksch, P., Insecticidal meliacarpin (C-seco limonoids) from Melia azedarach (1999) Phytochemistry, 50, pp. 977-982
- Del Mendez, M.C., Elías, F., Aragao, M., Gimeno, E.J., Riet-Correa, F., Intoxication of cattle by the fruits of Melia azedarach (2002) Vet. Hum. Toxicol., 44, pp. 145-148
- Denizot, F., Lang, R., Rapid colorimetric assay for cell growth and survival (1986) J. Immunol. Methods, 89, pp. 271-277
- Huang, R.Ch., Tadera, K., Yagi, F., Minami, Y., Okamura, H., Iwagawa, T., Nakatani, M., Limonoids from Melia azedarach (1996) Phytochemistry, 43, pp. 581-583
- Kim, M., Kim, S.K., Park, B.N., Lee, K.H., Min, G.H., Seoh, J.Y., Park, C.G., Kook, Y.H., Antiviral effects of 28-deacetylsendanin on herpes simplex virus-1 replication (1999) Phytochemistry, 43, pp. 103-112
- Kraus, W., Bokel, M., Bruhn, A., Cramer, R., Klaiber, I., Klenk, A., Nagl, G., Vogler, B., Structure determination by NMR of azadirachtin and related compounds from Azadirachta indica A. Juss (Meliaceae) (1987) Tetrahedron, 43, pp. 2817-2830
- Lee, S.M., Klocke, J.A., Barnby, M.A., Yamasaki, R.B., Balandrin, M.F., Insecticidal Constituents of Azadirachta indica and Melia azedarach (Meliaceae) (1991) ACS Symp. Ser., 449, pp. 293-304. , Naturally Occurring Pest Bioregulators (Hedin, P. A., ed.). Washington, DC, Washington
- Pifarré, M.P., Berra, A., Coto, C.E., Alché, L.E., Therapeutic action of meliacine, a plant-derived antiviral, on HSV-induced ocular disease in mice (2002) Exp. Eye Res., 75, pp. 327-334
- Takeya, K., Qiao, Z.-S., Hirobe, C., Itokawa, H., Cytotoxic azadirachtin-type limonoids from Melia azedarach (1996) Phytochemistry, 42, pp. 709-712
- Wachsman, M., Martino, V., Gutkind, G., Coussio, J., Coto, C., De Torres, R., Antiviral activity of a Melia azedarach plant extract (1982) Fitoterapia, 53, pp. 167-170
Citas:
---------- APA ----------
Alché, L.E., Ferek, G.A., Meo, M., Coto, C.E. & Maier, M.S.
(2003)
. An antiviral meliacarpin from leaves of Melia azedarach L. Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 58(3-4), 215-219.
http://dx.doi.org/10.1515/znc-2003-3-413---------- CHICAGO ----------
Alché, L.E., Ferek, G.A., Meo, M., Coto, C.E., Maier, M.S.
"An antiviral meliacarpin from leaves of Melia azedarach L."
Zeitschrift fur Naturforschung - Section C Journal of Biosciences 58, no. 3-4
(2003) : 215-219.
http://dx.doi.org/10.1515/znc-2003-3-413---------- MLA ----------
Alché, L.E., Ferek, G.A., Meo, M., Coto, C.E., Maier, M.S.
"An antiviral meliacarpin from leaves of Melia azedarach L."
Zeitschrift fur Naturforschung - Section C Journal of Biosciences, vol. 58, no. 3-4, 2003, pp. 215-219.
http://dx.doi.org/10.1515/znc-2003-3-413---------- VANCOUVER ----------
Alché, L.E., Ferek, G.A., Meo, M., Coto, C.E., Maier, M.S. An antiviral meliacarpin from leaves of Melia azedarach L. Z. Naturforsch. Sect. C J. Biosci. 2003;58(3-4):215-219.
http://dx.doi.org/10.1515/znc-2003-3-413