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Abstract:

Renal disease is the most important long-term complication of hemolytic-uremic syndrome (HUS). A comparative study of renal function was carried out in two groups of patients. Group 1 included 19 children followed for a median of 11 years, 1960-1980, with a low-sodium diet, antihypertensive drugs, and a restricted protein intake in the end stage of renal disease. Group 2 included 26 children treated for a median of 9 years, 1988-2002, on a low-sodium diet, early restriction of protein intake according to recommendations, and angiotensin converting enzyme inhibitors (ACEi). Long-term renal function was assessed by the inverse of the plasma creatinine concentration (1/[Cr]) over time. Linear regression lines were fitted to individual values of 1/[Cr] for each child. Regression coefficients of children in group 1 were all negative, ranging from -0.031 to -0.00043; 7 were significantly different from zero, indicating a linear fall in renal function over time. In contrast, children from group 2 had 11 negative slopes (only 1 significant) and 15 positive slopes, ranging from 0.17893 to -0.3899. Fisher's exact test showed that group 1 had significantly more children with negative slopes than group 2. This comparatively better long-term outcome of renal function in children under contemporary treatment was probably associated with early restriction of protein and use of ACEi. © IPNA 2004.

Registro:

Documento: Artículo
Título:Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome
Autor:Caletti, M.G.; Lejarraga, H.; Kelmansky, D.; Missoni, M.
Filiación:Nephrology Service, Garrahan Hospital, Combate de los Pozos 1881, 1245 Buenos Aires, Argentina
Service of Growth/Development, Garrahan Hospital, Buenos Aires, Argentina
Instituto del Cálculo, Faculdade de Ciencias Exactas, Univesidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Angiotensin converting enzyme inhibitors; Chronic renal failure; Hemolytic-uremic syndrome; Historical study; Protein intake; antihypertensive agent; creatinine; dipeptidyl carboxypeptidase inhibitor; enalapril; furosemide; prazosin; article; chronic kidney failure; clinical article; controlled study; correlation coefficient; creatinine blood level; female; Fisher exact test; follow up; hemolytic uremic syndrome; human; hypertension; kidney function; linear regression analysis; longitudinal study; male; priority journal; protein intake; protein restriction; proteinuria; sodium restriction; statistical significance; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Child; Child, Preschool; Diet, Protein-Restricted; Diet, Sodium-Restricted; Disease Progression; Female; Hemolytic-Uremic Syndrome; Humans; Infant; Kidney Failure, Chronic; Male; Time Factors; Treatment Outcome
Año:2004
Volumen:19
Número:10
Página de inicio:1148
Página de fin:1152
DOI: http://dx.doi.org/10.1007/s00467-004-1516-y
Título revista:Pediatric Nephrology
Título revista abreviado:Pediatr. Nephrol.
ISSN:0931041X
CODEN:PEDNE
CAS:creatinine, 19230-81-0, 60-27-5; enalapril, 75847-73-3; furosemide, 54-31-9; prazosin, 19216-56-9, 19237-84-4; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0931041X_v19_n10_p1148_Caletti

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Citas:

---------- APA ----------
Caletti, M.G., Lejarraga, H., Kelmansky, D. & Missoni, M. (2004) . Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome. Pediatric Nephrology, 19(10), 1148-1152.
http://dx.doi.org/10.1007/s00467-004-1516-y
---------- CHICAGO ----------
Caletti, M.G., Lejarraga, H., Kelmansky, D., Missoni, M. "Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome" . Pediatric Nephrology 19, no. 10 (2004) : 1148-1152.
http://dx.doi.org/10.1007/s00467-004-1516-y
---------- MLA ----------
Caletti, M.G., Lejarraga, H., Kelmansky, D., Missoni, M. "Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome" . Pediatric Nephrology, vol. 19, no. 10, 2004, pp. 1148-1152.
http://dx.doi.org/10.1007/s00467-004-1516-y
---------- VANCOUVER ----------
Caletti, M.G., Lejarraga, H., Kelmansky, D., Missoni, M. Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome. Pediatr. Nephrol. 2004;19(10):1148-1152.
http://dx.doi.org/10.1007/s00467-004-1516-y