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Abstract:

Scientific literature provides evidence about the use of steroids as an adjunct treatment to antiviral therapies. Immunomodulatory activity of some steroids would account for the recovery in patients with herpetic and other viral infections. However, in vitro studies have demonstrated a direct antiviral effect of this kind of molecules. In this review we discuss recent reports about the mechanism of antiviral action of steroids from animal and plant origin. Chemical structures of most active compounds are also provided. © 2010 Bentham Science Publishers Ltd.

Registro:

Documento: Artículo
Título:Plant and animal steroids a new hope to search for antiviral agents
Autor:Castilla, V.; Ramírez, J.; Coto, C.E.
Filiación:Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Departamento de Química Orgánica and UMYMFOR (FCEyN - CONICET), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
Palabras clave:Antiviral activity; Brassinosteroid; Dehydroepiandrosterone; Glucocorticoid; Progestagen; Seco-pregnane; Steroids; Virus; antivirus agent; brassinosteroid; gestagen; glucocorticoid; phytosterol; prasterone; pregnane derivative; steroid; ursolic acid; antiviral activity; article; Dengue virus; drug structure; herpes virus infection; Human immunodeficiency virus; immunomodulation; nonhuman; respiratory virus; retrovirus infection; SARS coronavirus; virus infection; virus inhibition; virus replication; Animals; Antiviral Agents; Humans; Plants; Steroids; Virus Diseases; Viruses
Año:2010
Volumen:17
Número:18
Página de inicio:1858
Página de fin:1873
DOI: http://dx.doi.org/10.2174/092986710791163975
Título revista:Current Medicinal Chemistry
Título revista abreviado:Curr. Med. Chem.
ISSN:09298673
CODEN:CMCHE
CAS:prasterone, 53-43-0; ursolic acid, 77-52-1; Antiviral Agents; Steroids
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09298673_v17_n18_p1858_Castilla

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Citas:

---------- APA ----------
Castilla, V., Ramírez, J. & Coto, C.E. (2010) . Plant and animal steroids a new hope to search for antiviral agents. Current Medicinal Chemistry, 17(18), 1858-1873.
http://dx.doi.org/10.2174/092986710791163975
---------- CHICAGO ----------
Castilla, V., Ramírez, J., Coto, C.E. "Plant and animal steroids a new hope to search for antiviral agents" . Current Medicinal Chemistry 17, no. 18 (2010) : 1858-1873.
http://dx.doi.org/10.2174/092986710791163975
---------- MLA ----------
Castilla, V., Ramírez, J., Coto, C.E. "Plant and animal steroids a new hope to search for antiviral agents" . Current Medicinal Chemistry, vol. 17, no. 18, 2010, pp. 1858-1873.
http://dx.doi.org/10.2174/092986710791163975
---------- VANCOUVER ----------
Castilla, V., Ramírez, J., Coto, C.E. Plant and animal steroids a new hope to search for antiviral agents. Curr. Med. Chem. 2010;17(18):1858-1873.
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