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Aznar, C.; Lopez-Bergami, P.; Brandariz, S.; Mariette, C.; Liegeard, P.; Alves, M.d.C.d.D.; Barreiro, E.L.; Carrasco, R.; Lafon, S.; Kaplan, D.; Miguez, H.; Camacho, C.; Levitus, G.; Mariano Levin, J.; Hontebeyrie, M. "Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection" (1995) FEMS Immunology and Medical Microbiology. 12(3-4):231-237
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Abstract:

Infection with Trypanosoma cruzi develops in three phases: acute, indeterminate or asymptomatic, and chronic phase (with cardiac or digestive manifestations). Moreover, transmission may occur from infected mothers to newborn, the so-called congenital form. In the present study, humoral responses against T. cruzi total extract and against the 13 amino acid peptide named R-13 derived from the parasite ribosomal P protein, previously described as a possible marker of chronic Chagas heart disease, were determined pateints and in blood bank donors from endemic areas. While in sera from acute phase, only IgM anti-T.cruzi response was observed, both IgM and IgG anti-T. cruzi antibodies were detected in sera from congenitally infected newborns. The percentage of positive response in sera from blood bank donors was relatively high in endemic regions. Antibodies against the R-13 peptide were present in a large proportion of cardiac chagasic patients but were totally lacking in patients with digestive form of Chagas' disease. Furthermore, anti-R-13 positive responses were detected in congenitally infected newborns. © 1995.

Registro:

Documento: Artículo
Título:Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection
Autor:Aznar, C.; Lopez-Bergami, P.; Brandariz, S.; Mariette, C.; Liegeard, P.; Alves, M.d.C.d.D.; Barreiro, E.L.; Carrasco, R.; Lafon, S.; Kaplan, D.; Miguez, H.; Camacho, C.; Levitus, G.; Mariano Levin, J.; Hontebeyrie, M.
Filiación:Centre de Biologie Médicale Spécialisée, Institut Pasteur, 28, rue du Dr Roux, 75724 Paris cedex 15, France
Unité d'Immunoparasitologie, Institut Pasteur, 28, rue du Dr Roux, 75724 Paris cedex 15, France
Instituto de Investigaciones en Ingenieria Genetica y Biologia Molecular (Ingebi-Conicet), Obligado 2490, 1428 Buenos Aires, Argentina
Hemocentro de Brasilia, SMHN, quadra 501, CEP 70710 Brasilia, Brazil
Instituto Boliviano de Biologia de Altura, Casilla 717, La Paz, Bolivia
Palabras clave:Chagas disease diagnosis; Chagasic cardiomyopathy; Myocardites; Ribosomal P protein; Synthetic peptide; Trypanosoma cruzi; immunoglobulin m; parasite antibody; adult; article; blood donor; cardiomyopathy; chagas disease; congenital infection; controlled study; human; major clinical study; newborn; priority journal; trypanosoma cruzi; trypanosomiasis; Acute Disease; Animal; Antibodies, Protozoan; Argentina; Base Sequence; Blood Donors; Brazil; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Diagnosis, Differential; Human; Immunoglobulin Isotypes; Infant, Newborn; Molecular Sequence Data; Ribosomal Proteins; Seroepidemiologic Studies; Trypanosoma cruzi
Año:1995
Volumen:12
Número:3-4
Página de inicio:231
Página de fin:237
DOI: http://dx.doi.org/10.1016/0928-8244(95)00075-7
Título revista:FEMS Immunology and Medical Microbiology
Título revista abreviado:FEMS Immunol. Med. Microbiol.
ISSN:09288244
CODEN:FIMIE
CAS:immunoglobulin M, 9007-85-6; Antibodies, Protozoan; Immunoglobulin Isotypes; P-JL5 protein; Ribosomal Proteins
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09288244_v12_n3-4_p231_Aznar

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Citas:

---------- APA ----------
Aznar, C., Lopez-Bergami, P., Brandariz, S., Mariette, C., Liegeard, P., Alves, M.d.C.d.D., Barreiro, E.L.,..., Hontebeyrie, M. (1995) . Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection. FEMS Immunology and Medical Microbiology, 12(3-4), 231-237.
http://dx.doi.org/10.1016/0928-8244(95)00075-7
---------- CHICAGO ----------
Aznar, C., Lopez-Bergami, P., Brandariz, S., Mariette, C., Liegeard, P., Alves, M.d.C.d.D., et al. "Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection" . FEMS Immunology and Medical Microbiology 12, no. 3-4 (1995) : 231-237.
http://dx.doi.org/10.1016/0928-8244(95)00075-7
---------- MLA ----------
Aznar, C., Lopez-Bergami, P., Brandariz, S., Mariette, C., Liegeard, P., Alves, M.d.C.d.D., et al. "Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection" . FEMS Immunology and Medical Microbiology, vol. 12, no. 3-4, 1995, pp. 231-237.
http://dx.doi.org/10.1016/0928-8244(95)00075-7
---------- VANCOUVER ----------
Aznar, C., Lopez-Bergami, P., Brandariz, S., Mariette, C., Liegeard, P., Alves, M.d.C.d.D., et al. Prevalence of anti-R-13 antibodies in human Trypanosoma cruzi infection. FEMS Immunol. Med. Microbiol. 1995;12(3-4):231-237.
http://dx.doi.org/10.1016/0928-8244(95)00075-7