Artículo

Estamos trabajando para incorporar este artículo al repositorio
Consulte el artículo en la página del editor
Consulte la política de Acceso Abierto del editor

Abstract:

Poly(vinyl alcohol) (PVA) is a hydrophilic, biocompatible and nontoxic polymer. However, because of its low water-resistance, some applications for PVA-based materials are limited (e.g., drug delivery systems and wound dressings). In the current work, PVA mats containing tetracycline hydrochloride (TC) were successfully developed by electrospinning. In order to improve the water stability of the systems, the cross-linking of the PVA matrix was induced by citric acid (CA) addition together with heating treatments (150 °C or 190 °C for 3 min). TC presence led to a strong increase in the electrical conductivity of the blends and as a result, fibers with about 44% lower diameter (270 nm) than that of the corresponding unloaded mats (485 nm) were obtained. Laser scanning confocal microscopy images indicated that TC was well distributed along the PVA nanofibers. The mats were evaluated by FTIR, which revealed chemical interactions between PVA hydroxyl groups and CA carboxylic ones. The treatment at 150 °C for 3 min proved to be the more suitable for the preparation of TC-containing mats with improved water resistance, maintaining the TC antimicrobial activity against both Escherichia coli and Staphylococcus aureus almost unaltered. These mats showed a burst release of TC, giving around 95% of the drug within the first hour of immersion in water. © 2016 Elsevier B.V.

Registro:

Documento: Artículo
Título:A simple green route to obtain poly(vinyl alcohol) electrospun mats with improved water stability for use as potential carriers of drugs
Autor:López-Córdoba, A.; Castro, G.R.; Goyanes, S.
Filiación:Universidad de Buenos Aires. Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Física de Buenos Aires (IFIBA), Facultad de Ciencias Exactas y Naturales, Buenos Aires, 1428, Argentina
Laboratorio de Nanobiomateriales, CINDEFI, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata-CONICET (CCT La Plata), La Plata, 1900, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina
Palabras clave:Electrospinning; Nanofibers; Poly(vinyl alcohol); Tetracycline hydrochloride; Water-insoluble mats; Bacteria; Biocompatibility; Biomaterials; Electrospinning; Escherichia coli; Nanofibers; Spinning (fibers); System stability; Textile blends; Anti-microbial activity; Chemical interactions; Drug delivery system; Electrical conductivity; Laser scanning confocal microscopy; Poly (vinyl alcohol) (PVA); Staphylococcus aureus; Tetracycline hydrochloride; Polyvinyl alcohols; antiinfective agent; citric acid; drug carrier; polyvinyl alcohol; tetracycline; water; chemistry; drug release; green chemistry; heat; infrared spectroscopy; kinetics; microbial sensitivity test; procedures; scanning electron microscopy; solubility; standard; thermogravimetry; tissue scaffold; ultraviolet spectrophotometry; Anti-Bacterial Agents; Citric Acid; Drug Carriers; Drug Liberation; Green Chemistry Technology; Hot Temperature; Kinetics; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Polyvinyl Alcohol; Reference Standards; Solubility; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Tetracycline; Thermogravimetry; Tissue Scaffolds; Water
Año:2016
Volumen:69
Página de inicio:726
Página de fin:732
DOI: http://dx.doi.org/10.1016/j.msec.2016.07.058
Título revista:Materials Science and Engineering C
Título revista abreviado:Mater. Sci. Eng. C
ISSN:09284931
CAS:citric acid, 126-44-3, 5949-29-1, 77-92-9, 8002-14-0; polyvinyl alcohol, 37380-95-3, 9002-89-5; tetracycline, 23843-90-5, 60-54-8, 64-75-5, 8021-86-1; water, 7732-18-5; Anti-Bacterial Agents; Citric Acid; Drug Carriers; Polyvinyl Alcohol; Tetracycline; Water
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284931_v69_n_p726_LopezCordoba

Referencias:

  • Mano, F., Aroso, I.M., Barreiros, S., Borges, J.P., Reis, R.L., Duarte, A.R.C., Paiva, A., Production of poly(vinyl alcohol) (PVA) fibers with encapsulated natural deep eutectic solvent (NADES) using electrospinning (2015) ACS Sustain. Chem. Eng., 3, pp. 2504-2509
  • Frenot, A., Chronakis, I.S., Polymer nanofibers assembled by electrospinning (2003) Curr. Opin. Colloid Interface Sci., 8, pp. 64-75
  • Haroosh, H., Dong, Y., Lau, K.-T., Tetracycline hydrochloride (TCH)-loaded drug carrier based on PLA:PCL nanofibre mats: experimental characterisation and release kinetics modelling (2014) J. Mater. Sci., 49, pp. 6270-6281
  • Ribba, L., Parisi, M., D'Accorso, N.B., Goyanes, S., Electrospun nanofibrous mats: from vascular repair to osteointegration (2014) J. Biomed. Nanotechnol., 10, pp. 3508-3535
  • Parisi, M., Manzano, V.E., Flor, S., Lissarrague, M.H., Ribba, L., Lucangioli, S., D'Accorso, N.B., Goyanes, S., Polymeric Prosthetic Systems for Site-specific Drug Administration: Physical and Chemical Properties, Handbook of Polymers for Pharmaceutical Technologies (2015), pp. 369-412. , John Wiley & Sons, Inc; Choi, J., Yang, B.J., Bae, G.-N., Jung, J.H., Herbal extract incorporated nanofiber fabricated by an electrospinning technique and its application to antimicrobial air filtration (2015) ACS Appl. Mater. Interfaces, 7, pp. 25313-25320
  • Wagner, A., Poursorkhabi, V., Mohanty, A.K., Misra, M., Analysis of porous electrospun fibers from poly(l-lactic acid)/poly(3-hydroxybutyrate-co-3-hydroxyvalerate) blends (2014) ACS Sustain. Chem. Eng., 2, pp. 1976-1982
  • Chen, J., Lu, L., Wu, D., Yuan, L., Zhang, M., Hua, J., Xu, J., Green poly(ε-caprolactone) composites reinforced with electrospun polylactide/poly(ε-caprolactone) blend fiber mats (2014) ACS Sustain. Chem. Eng., 2, pp. 2102-2110
  • Forouharshad, M., Putti, M., Basso, A., Prato, M., Monticelli, O., Biobased system composed of electrospun sc-PLA/POSS/cyclodextrin fibers to remove water pollutants (2015) ACS Sustain. Chem. Eng., 3, pp. 2917-2924
  • Joshi, M.K., Tiwari, A.P., Pant, H.R., Shrestha, B.K., Kim, H.J., Park, C.H., Kim, C.S., In situ generation of cellulose nanocrystals in polycaprolactone nanofibers: effects on crystallinity, mechanical strength, biocompatibility, and biomimetic mineralization (2015) ACS Appl. Mater. Interfaces, 7, pp. 19672-19683
  • Destaye, A.G., Lin, C.-K., Lee, C.-K., Glutaraldehyde vapor cross-linked nanofibrous PVA mat with in situ formed silver nanoparticles (2013) ACS Appl. Mater. Interfaces, 5, pp. 4745-4752
  • Peresin, M.S., Vesterinen, A.-H., Habibi, Y., Johansson, L.-S., Pawlak, J.J., Nevzorov, A.A., Rojas, O.J., Crosslinked PVA nanofibers reinforced with cellulose nanocrystals: water interactions and thermomechanical properties (2014) J. Appl. Polym. Sci., 131. , n/a-n/a
  • Supaphol, P., Chuangchote, S., On the electrospinning of poly (vinyl alcohol) nanofiber mats: a revisit (2008) J. Appl. Polym. Sci., 108, pp. 969-978
  • Bolto, B., Tran, T., Hoang, M., Xie, Z., Crosslinked poly(vinyl alcohol) membranes (2009) Prog. Polym. Sci., 34, pp. 969-981
  • Demitri, C., Del Sole, R., Scalera, F., Sannino, A., Vasapollo, G., Maffezzoli, A., Ambrosio, L., Nicolais, L., Novel superabsorbent cellulose-based hydrogels crosslinked with citric acid (2008) J. Appl. Polym. Sci., 110, pp. 2453-2460
  • Reddy, N., Yang, Y., Citric acid cross-linking of starch films (2010) Food Chem., 118, pp. 702-711
  • Stone, S.A., Gosavi, P., Athauda, T.J., Ozer, R.R., In situ citric acid crosslinking of alginate/polyvinyl alcohol electrospun nanofibers (2013) Mater. Lett., 112, pp. 32-35
  • Shi, R., Bi, J., Zhang, Z., Zhu, A., Chen, D., Zhou, X., Zhang, L., Tian, W., The effect of citric acid on the structural properties and cytotoxicity of the polyvinyl alcohol/starch films when molding at high temperature (2008) Carbohydr. Polym., 74, pp. 763-770
  • Gohil, J., Bhattacharya, A., Ray, P., Studies on the crosslinking of poly (vinyl alcohol) (2006) J. Polym. Res., 13, pp. 161-169
  • Chopra, I., Roberts, M., Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance (2001) Microbiol. Mol. Biol. Rev., 65, pp. 232-260
  • Schneider, C.A., Rasband, W.S., Eliceiri, K.W., NIH image to ImageJ: 25 years of image analysis (2012) Nat. Methods, 9, pp. 671-675
  • Pautke, C., Vogt, S., Kreutzer, K., Haczek, C., Wexel, G., Kolk, A., Imhoff, A.B., Tischer, T., Characterization of eight different tetracyclines: advances in fluorescence bone labeling (2010) J. Anat., 217, pp. 76-82
  • Bayón, B., Bucalá, V., Castro, G.R., Development of antimicrobial hybrid mesoporous silver phosphate–pectin microspheres for control release of levofloxacin (2016) Microporous Mesoporous Mater., 226, pp. 71-78
  • Costa, H.S., Mansur, A.A.P., Pereira, M.M., Mansur, H.S., Engineered hybrid scaffolds of poly(vinyl alcohol)/bioactive glass for potential bone engineering applications: synthesis, characterization, cytocompatibility, and degradation (2012) J. Nanomater., 2012, p. 4
  • Pattama, T., Uracha, R., Pitt, S., Drug-loaded electrospun mats of poly(vinyl alcohol) fibres and their release characteristics of four model drugs (2006) Nanotechnology, 17, p. 2317
  • Zamani, M., Morshed, M., Varshosaz, J., Jannesari, M., Controlled release of metronidazole benzoate from poly ε-caprolactone electrospun nanofibers for periodontal diseases (2010) Eur. J. Pharm. Biopharm., 75, pp. 179-185
  • Varanda, F., Pratas de Melo, M.J., Caço, A.I., Dohrn, R., Makrydaki, F.A., Voutsas, E., Tassios, D., Marrucho, I.M., Solubility of antibiotics in different solvents. 1. hydrochloride forms of tetracycline, moxifloxacin, and ciprofloxacin (2006) Ind. Eng. Chem. Res., 45, pp. 6368-6374
  • Regosz, A., Zuk, G., Studies on spectrophotometric determination of tetracycline and its degradation products (1980) Die Pharmazie, 35, pp. 24-26
  • Verreck, G., Chun, I., Peeters, J., Rosenblatt, J., Brewster, M., Preparation and characterization of nanofibers containing amorphous drug dispersions generated by electrostatic spinning (2003) Pharm. Res., 20, pp. 810-817
  • Tungprapa, S., Jangchud, I., Supaphol, P., Release characteristics of four model drugs from drug-loaded electrospun cellulose acetate fiber mats (2007) Polymer, 48, pp. 5030-5041
  • Hassani, M., Lázaro, R., Pérez, C., Condón, S., Pagán, R., Thermostability of oxytetracycline, tetracycline, and doxycycline at ultrahigh temperatures (2008) J. Agric. Food Chem., 56, pp. 2676-2680
  • Holland, B.J., Hay, J.N., The thermal degradation of poly(vinyl alcohol) (2001) Polymer, 42, pp. 6775-6783
  • Mansur, H.S., Sadahira, C.M., Souza, A.N., Mansur, A.A.P., FTIR spectroscopy characterization of poly (vinyl alcohol) hydrogel with different hydrolysis degree and chemically crosslinked with glutaraldehyde (2008) Mater. Sci. Eng. C, 28, pp. 539-548
  • Gunasekaran, S., Varadhan, S.R., Karunanidhi, N., Qualitative analysis of the infrared bands of tetracycline and ampicilin (1996) Proc. Indian Natl. Sci. Acad., 62, pp. 309-316
  • Assumpção, P.C., Ambrozini, B., Machado, L.C.M., Ferreira, A.P.G., Cavalheiro, É.T.G., Decomposição Térmica de Tetraciclinas (2015) Brazilian Journal of Thermal Analysis, 7, pp. 274-277
  • Van Etten, E.A., Ximenes, E.S., Tarasconi, L.T., Garcia, I.T.S., Forte, M.M.C., Boudinov, H., Insulating characteristics of polyvinyl alcohol for integrated electronics (2014) Thin Solid Films, 568, pp. 111-116

Citas:

---------- APA ----------
López-Córdoba, A., Castro, G.R. & Goyanes, S. (2016) . A simple green route to obtain poly(vinyl alcohol) electrospun mats with improved water stability for use as potential carriers of drugs. Materials Science and Engineering C, 69, 726-732.
http://dx.doi.org/10.1016/j.msec.2016.07.058
---------- CHICAGO ----------
López-Córdoba, A., Castro, G.R., Goyanes, S. "A simple green route to obtain poly(vinyl alcohol) electrospun mats with improved water stability for use as potential carriers of drugs" . Materials Science and Engineering C 69 (2016) : 726-732.
http://dx.doi.org/10.1016/j.msec.2016.07.058
---------- MLA ----------
López-Córdoba, A., Castro, G.R., Goyanes, S. "A simple green route to obtain poly(vinyl alcohol) electrospun mats with improved water stability for use as potential carriers of drugs" . Materials Science and Engineering C, vol. 69, 2016, pp. 726-732.
http://dx.doi.org/10.1016/j.msec.2016.07.058
---------- VANCOUVER ----------
López-Córdoba, A., Castro, G.R., Goyanes, S. A simple green route to obtain poly(vinyl alcohol) electrospun mats with improved water stability for use as potential carriers of drugs. Mater. Sci. Eng. C. 2016;69:726-732.
http://dx.doi.org/10.1016/j.msec.2016.07.058