Artículo

Schwengber, A.; Prado, H.J.; Zilli, D.A.; Bonelli, P.R.; Cukierman, A.L. "Carbon nanotubes buckypapers for potential transdermal drug delivery" (2015) Materials Science and Engineering C. 57:7-13
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Abstract:

Abstract Drug loaded buckypapers based on different types of carbon nanotubes (CNTs) were prepared and characterized in order to evaluate their potentialities for the design of novel transdermal drug delivery systems. Lab-synthesized CNTs as well as commercial samples were employed. Clonidine hydrochloride was used as model drug, and the influence of composition of the drug loaded buckypapers and processing variables on in vitro release profiles was investigated. To examine the influence of the drug nature the evaluation was further extended to buckypapers prepared with flurbiprofen and one type of CNTs, their selection being based on the results obtained with the former drug. Scanning electronic microscopy images indicated that the model drugs were finely dispersed on the CNTs. Differential scanning calorimetry, and X-ray diffraction pointed to an amorphous state of both drugs in the buckypapers. A higher degree of CNT-drug superficial interactions resulted in a slower release of the drug. These interactions were in turn affected by the type of CNTs employed (single wall or multiwall CNTs), their functionalization with hydroxyl or carboxyl groups, the chemical structure of the drug, and the CNT:drug mass ratio. Furthermore, the application of a second layer of drug free CNTs on the loaded buckypaper, led to decelerate the drug release and to reduce the burst effect. © 2015 Elsevier B.V.

Registro:

Documento: Artículo
Título:Carbon nanotubes buckypapers for potential transdermal drug delivery
Autor:Schwengber, A.; Prado, H.J.; Zilli, D.A.; Bonelli, P.R.; Cukierman, A.L.
Filiación:PINMATE-Departamento de Industrias, Universidad de Buenos Aires, Ciudad Universitaria, Intendente Güiraldes 2160Buenos Aires C1428EGA, Argentina
Departamento de Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956Buenos Aires C1113AAD, Argentina
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. Rivadavia 1917Buenos Aires C1033AAJ, Argentina
Palabras clave:Buckypapers; Carbon nanotubes; Clonidine hydrochloride; Flurbiprofen; Transdermal drug delivery; Carbon; Carbon nanotubes; Differential scanning calorimetry; Drug products; Multiwalled carbon nanotubes (MWCN); X ray diffraction; Yarn; Bucky paper; Clonidine hydrochloride; Flurbiprofen; Functionalizations; Processing variables; Scanning electronic microscopy; Transdermal drug delivery; Transdermal drug delivery systems; Drug interactions; carbon nanotube; delayed release formulation; flurbiprofen; fullerene derivative; nanocapsule; nonsteroid antiinflammatory agent; absorption; chemistry; delayed release formulation; diffusion; feasibility study; intradermal drug administration; materials testing; nanopore; paper; particle size; ultrastructure; Absorption, Physicochemical; Administration, Cutaneous; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Diffusion; Feasibility Studies; Flurbiprofen; Fullerenes; Materials Testing; Nanocapsules; Nanopores; Nanotubes, Carbon; Paper; Particle Size
Año:2015
Volumen:57
Página de inicio:7
Página de fin:13
DOI: http://dx.doi.org/10.1016/j.msec.2015.07.030
Título revista:Materials Science and Engineering C
Título revista abreviado:Mater. Sci. Eng. C
ISSN:09284931
CAS:flurbiprofen, 5104-49-4; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Flurbiprofen; Fullerenes; Nanocapsules; Nanotubes, Carbon
Registro:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_09284931_v57_n_p7_Schwengber

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Citas:

---------- APA ----------
Schwengber, A., Prado, H.J., Zilli, D.A., Bonelli, P.R. & Cukierman, A.L. (2015) . Carbon nanotubes buckypapers for potential transdermal drug delivery. Materials Science and Engineering C, 57, 7-13.
http://dx.doi.org/10.1016/j.msec.2015.07.030
---------- CHICAGO ----------
Schwengber, A., Prado, H.J., Zilli, D.A., Bonelli, P.R., Cukierman, A.L. "Carbon nanotubes buckypapers for potential transdermal drug delivery" . Materials Science and Engineering C 57 (2015) : 7-13.
http://dx.doi.org/10.1016/j.msec.2015.07.030
---------- MLA ----------
Schwengber, A., Prado, H.J., Zilli, D.A., Bonelli, P.R., Cukierman, A.L. "Carbon nanotubes buckypapers for potential transdermal drug delivery" . Materials Science and Engineering C, vol. 57, 2015, pp. 7-13.
http://dx.doi.org/10.1016/j.msec.2015.07.030
---------- VANCOUVER ----------
Schwengber, A., Prado, H.J., Zilli, D.A., Bonelli, P.R., Cukierman, A.L. Carbon nanotubes buckypapers for potential transdermal drug delivery. Mater. Sci. Eng. C. 2015;57:7-13.
http://dx.doi.org/10.1016/j.msec.2015.07.030